Sucralose - ≥98% , CAS No.56038-13-2

CAS: 56038-13-2 Cat. No.: S107614 Peso molecular: 397.63 Beilstein Registry Number: 3654410 Número EC: 259-952-2 PubChem CID: 71485
Disponible para pedir
GRADE & PURITY ≥98%
Synonyms
E955 | 4,1',6'-Trichloro-4,1',6'-trideoxy-galacto-sucrose | Biocoline | CCG-213995 | Sucrazit | CCRIS 8449 | Citric acid, trisodium salt | INS-955 | SUCRALOSE [II] | AKOS015962432 | alpha-D-Galactopyranoside, 1,6-dichloro-1,6-dideoxy-beta-D-fructofuranosy
Storage
Room temperature
Shipped In
Normal
 ·  off list, applied to all prices below.
Size
Estado
Price
Qty
5g
S107614-5g
9

9,90US$

14,90US$
Guardar 5,00 US$ (33.56%)
25g
S107614-25g
3

23,90US$

35,90US$
Guardar 12,00 US$ (33.43%)
100g
S107614-100g
4

68,90US$

103,90US$
Guardar 35,00 US$ (33.69%)
500g
S107614-500g
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.

93,90US$

140,90US$
Guardar 47,00 US$ (33.36%)
Enter a quantity for the sizes you want to add.
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Why this grade

≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Room temperature Ships Normal Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 27 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Descripción general

Sucralose is a non-caloric sugar used as a sweetener that activates T1R2/T1R3 sweet taste receptors and modulates Glukagon-like peptide-1, glucose-dependent insulinotrophic peptide, and incretin secretion.

Specifications

Sinónimos
E955 | 4, 1', 6'-Trichloro-4, 1', 6'-trideoxy-galacto-sucrose | Biocoline | CCG-213995 | Sucrazit | CCRIS 8449 | Citric acid, trisodium salt | INS-955 | SUCRALOSE [II] | AKOS015962432 | alpha-D-Galactopyranoside, 1, 6-dichloro-1, 6-dideoxy-beta-D-fructofuranosy
Especificaciones y pureza
≥98%
Mecanismos bioquímicos y fisiológicos
A synthetic sweetener that can be detected by humans. It can activate the T1R2/T1R3 sweet taste receptors on intestinal endocrine cells, causing an increase in hormone secretion of glucagon like peptide-1 and glucose dependent insulin peptides.
Condiciones de almacenamiento de almacenamiento
Room temperature
Enviado en
Normal
Pureza
≥98%
Nombres e identificadores
Pubchem Sid488184657
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488184657
Sonrisas canónicasC(C1C(C(C(C(O1)OC2(C(C(C(O2)CCl)O)O)CCl)O)O)Cl)O
IUPAC Name(2R,3R,4R,5R,6R)-2-[(2R,3S,4S,5S)-2,5-bis(chloromethyl)-3,4-dihydroxyoxolan-2-yl]oxy-5-chloro-6-(hydroxymethyl)oxane-3,4-diol
InChIKeyBAQAVOSOZGMPRM-QBMZZYIRSA-N
INCHI1S/C12H19Cl3O8/c13-1-4-7(17)10(20)12(3-14,22-4)23-11-9(19)8(18)6(15)5(2-16)21-11/h4-11,16-20H,1-3H2/t4-,5-,6+,7-,8+,9-,10+,11-,12+/m1/s1
Isómeros SMILES C([C@@H]1[C@@H]([C@@H]([C@H]([C@H](O1)O[C@]2([C@H]([C@@H]([C@H](O2)CCl)O)O)CCl)O)O)Cl)O
WGK Alemania 3
RTECS LW5440140
PubChem CID 71485
Peso molecular 397.63
Beilstein 3654410
Reaxy-Rn 3654410

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganic oxygen compounds
ClaseOrganooxygen compounds
SubclassCarbohydrates and carbohydrate conjugates
Intermediate Tree Nodes Glycosyl compounds
Direct ParentC-glycosyl compounds
Alternative Parents Ketals  Oxanes  Monosaccharides  Tetrahydrofurans  Secondary alcohols  Chlorohydrins  Oxacyclic compounds  Primary alcohols  Organochlorides  Hydrocarbon derivatives  Alkyl chlorides  
Molecular FrameworkAliphatic heteromonocyclic compounds
Substituents C-glycosyl compound - Ketal - Oxane - Monosaccharide - Tetrahydrofuran - Secondary alcohol - Chlorohydrin - Halohydrin - Acetal - Oxacycle - Organoheterocyclic compound - Hydrocarbon derivative - Organohalogen compound - Organochloride - Primary alcohol - Alkyl halide - Alkyl chloride - Alcohol - Aliphatic heteromonocyclic compound
DescripciónThis compound belongs to the class of organic compounds known as c-glycosyl compounds. These are glycoside in which a sugar group is bonded through one carbon to another group via a C-glycosidic bond.
External Descriptors organochlorine compound - disaccharide derivative
Estructura 3D
Modelo de Estructura Química Interactiva





Objetivos asociados (humanos)
CA2 Tclin Carbonic anhydrase 2 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CA2 Tclin Carbonic anhydrase II (17698 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CA9 Tclin Carbonic anhydrase IX (8255 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Homo sapiens (32628 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TAS2R31 Tchem Taste receptor type 2 member 31 (86 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TAS2R10 Tchem Taste receptor type 2 member 10 (51 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HEK-293T (167025 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TAS2R46 Tchem Taste receptor type 2 member 46 (155 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Objetivos asociados (no humanos)
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mecanismos de acción
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

22 results found

Lot NumberCertificate TypeFechaArticulo
L2519059Certificate of AnalysisMay 12, 2025 S107614
L2511117Certificate of AnalysisMay 12, 2025 S107614
G2515589Certificate of AnalysisMay 12, 2025 S107614
G2515588Certificate of AnalysisMay 12, 2025 S107614
G2515326Certificate of AnalysisMay 12, 2025 S107614
J2424782Certificate of AnalysisSep 27, 2024 S107614
J2424757Certificate of AnalysisSep 27, 2024 S107614
J2424754Certificate of AnalysisSep 27, 2024 S107614
G23201089Certificate of AnalysisJun 29, 2023 S107614
G23201092Certificate of AnalysisJun 29, 2023 S107614
G23201090Certificate of AnalysisJun 29, 2023 S107614
G23201087Certificate of AnalysisJun 29, 2023 S107614
G23201084Certificate of AnalysisJun 29, 2023 S107614
G23201080Certificate of AnalysisJun 29, 2023 S107614
A2329032Certificate of AnalysisMar 07, 2022 S107614
E2306631Certificate of AnalysisMar 07, 2022 S107614
E2306057Certificate of AnalysisMar 07, 2022 S107614
E2306044Certificate of AnalysisMar 07, 2022 S107614
C2224224Certificate of AnalysisMar 07, 2022 S107614
C2224222Certificate of AnalysisMar 07, 2022 S107614
C2224221Certificate of AnalysisMar 07, 2022 S107614
C2224220Certificate of AnalysisMar 07, 2022 S107614

Show more ⌵

Propiedades químicas y físicas
SolubilidadSoluble in Water.
Rotación específica [α]86.0° (C=1,H2O)
Punto de fusión (°C)130°C
Peso molecular397.600 g/mol
XLogP3-1.500
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Exact Mass396.015 Da
Monoisotopic Mass396.015 Da
Topological Polar Surface Area129.000 Ų
Heavy Atom Count23
Formal Charge0
Complexity405.000
Isotope Atom Count0
Defined Atom Stereocenter Count9
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Citations of This Product
Referencias
1. Lingling Tian, Jingyan Shi, Wei Li, Yuan Zhang, Xinghua Gao.  (2023)  Hollow Microfiber Assembly-Based Endocrine Pancreas-on-a-Chip for Sugar Substitute Evaluation.  Advanced Healthcare Materials,      [PMID:37751946] [10.1002/adhm.202302104]
2. He Yue, Chen Jianshe, Shi Weiyao, Shi Jingang, Ma Tian, Wang Xinmiao.  (2023)  Can nonvolatile tastants be smelled during food oral processing?.  CHEMICAL SENSES,      [PMID:37590987] [10.1093/chemse/bjad028]
3. Zhang Yuntao, Liu Lin, Wei Chunbo, Wang Xuanyang, Li Ran, Xu Xiaoqing, Zhang Yingfeng, Geng Guannan, Dang Keke, Ming Zhu, Tao Xinmiao, Xu Huan, Yan Xuemin, Zhang Jia, Hu Jinxia, Li Ying.  (2023)  Vitamin K2 supplementation improves impaired glycemic homeostasis and insulin sensitivity for type 2 diabetes through gut microbiome and fecal metabolites.  BMC Medicine,  21  (1): (1-16).  [PMID:37147641] [10.1186/s12916-023-02880-0]
4. Xue Mei, Wenchang Wang, Qingyi Li, Minxian Wu, Liyin Bu, Zhidong Chen.  (2023)  A novel electrochemical sensor based on gold nanobipyramids and poly-L-cysteine for the sensitive determination of trilobatin.  ANALYST,  148  (10): (2335-2342).  [PMID:37186001] [10.1039/D3AN00368J]
5. Xuejiao Zhang, Jiaxin Gu, Congying Zhao, Yaozhong Hu, Bowei Zhang, Jin Wang, Huan Lv, Xuemeng Ji, Shuo Wang.  (2021)  Sweeteners Maintain Epithelial Barrier Function Through the miR-15b/RECK/MMP-9 Axis, Remodel Microbial Homeostasis, and Attenuate Dextran Sodium Sulfate-Induced Colitis in Mice.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:34962394] [10.1021/acs.jafc.1c06788]
6. Xiaofeng Wei, Ying Chen, Shan He, Huiting Lian, Xuegong Cao, Bin Liu.  (2021)  L-histidine-regulated zeolitic imidazolate framework modified electrochemical interface for enantioselective determination of L-glutamate.  ELECTROCHIMICA ACTA,      [PMID:] [10.1016/j.electacta.2021.139464]
7. Ferry Saputra, Yu-Heng Lai, Rey Arturo T. Fernandez, Allan Patrick G. Macabeo, Hong-Thih Lai, Jong-Chin Huang, Chung-Der Hsiao.  (2021)  Acute and Sub-Chronic Exposure to Artificial Sweeteners at the Highest Environmentally Relevant Concentration Induce Less Cardiovascular Physiology Alterations in Zebrafish Larvae.  Biology-Basel,  10  (6): (548).  [PMID:34207293] [10.3390/biology10060548]
8. Pingping Cui, Qiuxiang Yin, Shihao Zhang, Xiaowei Cheng, Jiayu Dai, Zaixiang Zhang, Ling Zhou, Chuang Xie.  (2019)  The effect of solvents on crystal morphology of sucralose: Experiments and molecular dynamics simulation studies.  JOURNAL OF CRYSTAL GROWTH,      [PMID:] [10.1016/j.jcrysgro.2019.125398]
9. Yong Li, Tingting Yang, Qing Yao, Songsong Li, En Fang, Yankun Li, Chao Liu, Weimin Li.  (2019)  Metformin prevents colonic barrier dysfunction by inhibiting mast cell activation in maternal separation-induced IBS-like rats.  NEUROGASTROENTEROLOGY AND MOTILITY,  31  (5): (e13556).  [PMID:30740845] [10.1111/nmo.13556]
10. Yin Xu, Ying Wu, Wei Zhang, Xiaohui Fan, Yan Wang, Hui Zhang.  (2018)  Performance of artificial sweetener sucralose mineralization via UV/O3 process: Kinetics, toxicity and intermediates.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2018.07.090]
11. Hongmei Zhang, Shixin Sun, Yanqing Wang, Zhenghao Fei, Jian Cao.  (2018)  Binding mechanism of five typical sweeteners with bovine serum albumin.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:30015031] [10.1016/j.saa.2018.07.013]
12. Hongmei Zhang, Shixin Sun, Yanqing Wang, Jian Cao.  (2017)  Interaction of sucralose with whey protein: Experimental and molecular modeling studies.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:28666158] [10.1016/j.saa.2017.06.030]
13. Jiang Ting-Fu, Chong Lei, Yue Mei-E, Wang Yuan-Hong, Lv Zhi-Hua.  (2015)  Separation and Determination of Carbohydrates in Food Samples by Capillary Electrophoresis Using Dynamically Coating the Capillary with Indirect UV Detection.  Food Analytical Methods,  (10): (2588-2594).  [PMID:] [10.1007/s12161-015-0157-z]
14. Longmei Yao, Xue Mei, Jiajia Zhi, Wenchang Wang, Qingyi Li, Ding Jiang, Xiaohui Chen, Zhidong Chen.  (2024)  A novel electrochemiluminescent sensor based on AgMOF@N-CD composites for sensitive detection of trilobatin.  ANALYST,      [PMID:39264159] [10.1039/D4AN01102C]
15. Dali Zhuo, Xiaoyu Dong, Linghuan Li, Ronghua Zeng, Chao Tan, Hong Luo, Zhirong Zou.  (2025)  Detection of Ca2+ in water samples and calcium gluconate oral liquids using gas pressure meter as portable detector.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2025.113116]
16. Jingyan Shi, Jianing Li, Wentao Su, Chang Xue, Yuan Zhang, Xinghua Gao.  (2024)  Engineered microenvironments and pancreatic islet-on-chips for screening sugar substitute and antidiabetic compounds.  FOOD RESEARCH INTERNATIONAL,      [PMID:39614569] [10.1016/j.foodres.2024.115084]
17. Li Hao, Du Yu, Cheng Kaiwen, Chen Yuxi, Wei Ling, Pei Yujun, Wang Xiaoyu, Wang Lan, Zhang Ye, Hu Xiaoxin, Lu Yi, Zhu Xiangjia.  (2024)  Gut microbiota-derived indole-3-acetic acid suppresses high myopia progression by promoting type I collagen synthesis.  Cell Discovery,  10  (1): (1-14).  [PMID:39187483] [10.1038/s41421-024-00709-5]
18. Li Zhang, Lei Feng, Lin Yang, Hao Wan.  (2025)  Noninvasive Detection and Monitoring of the Integrity of the Intestinal Barrier through NIR-II Fluorescence Imaging and Colorimetric Urinalysis.  ACS Applied Materials & Interfaces,      [PMID:39977645] [10.1021/acsami.4c20263]
19. Zizhang Wang, Hao Li, Yuxiang Weng.  (2024)  OsFKBP12 transduces the sucrose signal from OsNIN8 to the OsTOR pathway in a loosely binding manner for cell division.  iScience,      [PMID:39811636] [10.1016/j.isci.2024.111555]
20. Yue He, Jianshe Chen, Weiyao Shi, Jingang Shi.  (2024)  Retronasal sensation of nonvolatile sweeteners and its impacts on the flavor perception of beverages.  FOOD QUALITY AND PREFERENCE,      [PMID:] [10.1016/j.foodqual.2024.105107]
21. Jing Xiao, Dali Zhuo, Jiayuan Tang, Jihong Chen, Chao Tan, Shu Zhang, Shichao Li, Zhirong Zou.  (2024)  Selective and sensitive detection of cyclamate in beverages using a portable pressure meter: A specific reaction-based analytical kit.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2024.110959]
22. Luyao Yang, Shuangshuang Wang, Jing Jin, Jiahui Wang, Wenyue Chen, Yun Xue, Liang Sheng, Yongning Zhai, Weifeng Yao.  (2024)  Sucralose triggers insulin resistance leading to follicular dysplasia in mice.  REPRODUCTIVE TOXICOLOGY,      [PMID:38880404] [10.1016/j.reprotox.2024.108644]
23. Wenjiao Liu, Han wang, Qi Mu, Ting Gong.  (2024)  Taste receptor T1R3 regulates testosterone synthesis via the cAMP-PKA-SP1 pathway in testicular Leydig cells.  THERIOGENOLOGY,      [PMID:39476553] [10.1016/j.theriogenology.2024.10.019]
24. Jun Hu, Ji Feng, Yan Bai, Zhi-Sheng Yao, Xiao-Yu Wu, Xin-Yu Hong, Guo-Dong Lu, Kun Xue.  (2025)  Sucralose Promotes Benzo(a)Pyrene-Induced Renal Toxicity in Mice by Regulating P-glycoprotein.  Antioxidants,  14  (4): (474).  [PMID:40298799] [10.3390/antiox14040474]
25. Wen Zhang, Shiyuan Ni, Zike Huang, Zhequan Wang, Zhiwei Liu.  (2025)  Spatiotemporal Variations and Future Trends of Sucralose Contamination in Major Rivers of Zhejiang, China: An Emerging Concern and Sustainability Challenge.  Sustainability,  17  (22): (9935).  [PMID:] [10.3390/su17229935]
26. Lele Chen, Guanchi Liu, Wei Su, Xiaoxue Hu, Jianshe Chen, Yue He, Xinmiao Wang.  (2025)  Retro-nasal perception of sucralose aerosols in model wine systems.  FOOD RESEARCH INTERNATIONAL,      [PMID:41652693] [10.1016/j.foodres.2025.118282]
27. Yuqing Liang, Yan Liu, Xuelong Cao, Qi Yan, Qiuning Hu, Jiahe Zhuang, Defu He.  (2026)  Sucralose and PMMA Microplastics Synergistically Induce Obesity with Altered Locomotion and Metabolism in Caenorhabditis elegans.  ENVIRONMENTAL SCIENCE & TECHNOLOGY,      [PMID:41739734] [10.1021/acs.est.5c12134]
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