Determine the necessary mass, volume, or concentration for preparing a solution.
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analytical standard Analytical standard for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Room temperature Ships Normal Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 23 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
| ALogP | 0.7 |
|---|
| Sonrisas canónicas | COC1=C(N=CN=C1OC)NS(=O)(=O)C2=CC=C(C=C2)N |
|---|---|
| IUPAC Name | 4-amino-N-(5,6-dimethoxypyrimidin-4-yl)benzenesulfonamide |
| InChIKey | PJSFRIWCGOHTNF-UHFFFAOYSA-N |
| INCHI | 1S/C12H14N4O4S/c1-19-10-11(14-7-15-12(10)20-2)16-21(17,18)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H,14,15,16) |
| Isómeros SMILES | COC1=C(N=CN=C1OC)NS(=O)(=O)C2=CC=C(C=C2)N |
| PubChem CID | 17134 |
| Peso molecular | 310.33 |
| Beilstein | 625453 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Benzenoids |
| Clase | Benzene and substituted derivatives |
| Subclass | Benzenesulfonamides |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Aminobenzenesulfonamides |
| Alternative Parents | Benzenesulfonyl compounds Aniline and substituted anilines Alkyl aryl ethers Pyrimidines and pyrimidine derivatives Organosulfonamides Imidolactams Heteroaromatic compounds Aminosulfonyl compounds Azacyclic compounds Primary amines Organopnictogen compounds Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aromatic heteromonocyclic compounds |
| Substituents | Aminobenzenesulfonamide - Benzenesulfonyl group - Aniline or substituted anilines - Alkyl aryl ether - Pyrimidine - Organosulfonic acid amide - Imidolactam - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Sulfonyl - Aminosulfonyl compound - Heteroaromatic compound - Organoheterocyclic compound - Ether - Azacycle - Organic oxygen compound - Organic oxide - Amine - Organic nitrogen compound - Organopnictogen compound - Primary amine - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Aromatic heteromonocyclic compound |
| Descripción | This compound belongs to the class of organic compounds known as aminobenzenesulfonamides. These are organic compounds containing a benzenesulfonamide moiety with an amine group attached to the benzene ring. |
| External Descriptors | sulfonamide - pyrimidines |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Fecha | Articulo |
|---|---|---|---|
| Certificate of Analysis | Jan 04, 2023 | S118396 |
| Punto de fusión (°C) | 197 °C |
|---|---|
| Peso molecular | 310.330 g/mol |
| XLogP3 | 0.700 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 8 |
| Rotatable Bond Count | 5 |
| Exact Mass | 310.074 Da |
| Monoisotopic Mass | 310.074 Da |
| Topological Polar Surface Area | 125.000 Ų |
| Heavy Atom Count | 21 |
| Formal Charge | 0 |
| Complexity | 419.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Mingguo Peng, Yicui Wang, Chunge Wu, Xuewen Cai, Yao Wu, Erdeng Du, Lu Zheng, Jiajun Fu. (2023) Investigating sulfonamides - Human serum albumin interactions: A comprehensive approach using multi-spectroscopy, DFT calculations, and molecular docking. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, [PMID:37862782] [10.1016/j.bbrc.2023.10.040] |
| 2. Jing Wang, Yong Zhang, Fubin Liu, Ying Liu, Litao Wang, Guihua Gao. (2023) Preparation of a Multifunctional and Multipurpose Chitosan/Cyclodextrin/MIL-68(Al) Foam Column and Examining Its Adsorption Properties for Anionic and Cationic Dyes and Sulfonamides. ACS Omega, [PMID:37692232] [10.1021/acsomega.3c03897] |
| 3. Meiling Ping, Wenchao Lv, Chen Yang, Qian Chen, Zongwen Wang, Fengfu Fu. (2023) A Paper-Based Multicolor Colorimetric Aptasensor for the Visual Determination of Multiple Sulfonamides Based on Aptamer-Functionalized Magnetic Beads and NADH–Ascorbic Acid-Mediated Gold Nanobipyramids. Chemosensors, 11 (7): (386). [PMID:] [10.3390/chemosensors11070386] |
| 4. Zongwen Wang, Xiating Li, Feng Zhang, Yu Gao, Jintian Cheng, FengFu Fu. (2023) Regulating the Growth Rate of Gold Nanobipyramids via a HCl-NADH-Ascorbic Acid System toward a Dual-Channel Multicolor Colorimetric Immunoassay for Simultaneously Screening and Detecting Multiple Sulfonamides. ANALYTICAL CHEMISTRY, [PMID:37382204] [10.1021/acs.analchem.3c01928] |
| 5. Ligui Wu, Mingyu Wang, Lingling Rong, Wenbiao Wang, Linwei Chen, Qiaofeng Wu, Haoyu Sun, Xiangfeng Huang, Xiaoming Zou. (2022) Structural effects of sulfonamides on the proliferation dynamics of sulfonamide resistance genes in the sequencing batch reactors and the mechanism. Journal of Environmental Sciences, [PMID:37778792] [10.1016/j.jes.2022.11.014] |
| 6. Zhangsong Jiang, Xiangfeng Huang, Qiaofeng Wu, Mi Li, Qili Xie, Zuwen Liu, Xiaoming Zou. (2022) Adsorption of sulfonamides on polyamide microplastics in an aqueous solution: behavior, structural effects, and its mechanism. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2022.140452] |
| 7. Mi Li, Xiaoyu Xiao, Zhangsong Jiang, Haihui Tang, Lingling Rong, Tiao Zhang, Taijia Li, Cui Hu, Ligui Wu, Xiaoming Zou. (2021) Metagenomic Insight into Sulfonamide-Induced Variation in Antibiotic Resistome of Soil Associated with Taxonomy, Mobile Genetic Elements (MGEs), and Function. ACS Agricultural Science & Technology, [PMID:] [10.1021/acsagscitech.1c00222] |
| 8. Xie Yizhen, Li Qiuyi, Qin Lulu, Zhou Xiaobin, Fan Yinming. (2021) Multi-templates surface molecularly imprinted polymer for simultaneous and rapid determination of sulfonamides and quinolones in water: effect of carbon-carbon double bond. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 28 (39): (54950-54959). [PMID:34120285] [10.1007/s11356-021-14794-6] |
| 9. Houmei Liu, Pian Jin, Mi Jiang, Yu Duan, Guozheng Zhu, Hui Yu, Hongdeng Qiu. (2021) Performance evaluation of silica microspheres functionalized by different amine-ligands for hydrophilic interaction chromatography. JOURNAL OF CHROMATOGRAPHY A, [PMID:33582513] [10.1016/j.chroma.2021.461967] |
| 10. Mi Li, Lingling Rong, Shifan Zhou, Xiaoyu Xiao, Ligui Wu, Yuxing Fan, Conghui Lu, Xiaoming Zou. (2020) Dissipation of Sulfonamides in Soil Emphasizing Taxonomy and Function of Microbiomes by Metagenomic Analysis. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, [PMID:33172257] [10.1021/acs.jafc.0c04496] |
| 11. Yinming Fan, Guolong Zeng, Xiaoguo Ma. (2020) Effects of prepolymerization on surface molecularly imprinted polymer for rapid separation and analysis of sulfonamides in water. JOURNAL OF COLLOID AND INTERFACE SCIENCE, [PMID:32182497] [10.1016/j.jcis.2020.03.027] |
| 12. Xiuna Jia, Sijia Li, Yudan Wang, Ting Wang, Xiaohong Hou. (2019) Adsorption Behavior and Mechanism of Sulfonamide Antibiotics in Aqueous Solution on a Novel MIL-101(Cr)@GO Composite. JOURNAL OF CHEMICAL AND ENGINEERING DATA, [PMID:] [10.1021/acs.jced.8b01152] |
| 13. Hong Bin, Ba Yongbing, Niu Li, Lou Fei, Zhang Zhaohuan, Liu Haiquan, Pan Yingjie, Zhao Yong. (2018) A Comprehensive Research on Antibiotic Resistance Genes in Microbiota of Aquatic Animals. Frontiers in Microbiology, [PMID:30093887] [10.3389/fmicb.2018.01617] |
| 14. Suyu Ren, Jing Tao, Feng Tan, Ying Cui, Xiaona Li, Jingwen Chen, Xin He, Yi Wang. (2018) Diffusive gradients in thin films based on MOF-derived porous carbon binding gel for in-situ measurement of antibiotics in waters. SCIENCE OF THE TOTAL ENVIRONMENT, [PMID:30029123] [10.1016/j.scitotenv.2018.07.013] |
| 15. Houmei Liu, Jia Chen, Zhan Li, Makoto Takafuji, Hirotaka Ihara, Hongdeng Qiu. (2016) A new route for synthesis of N-methylimidazolium-grafted silica stationary phase and reevaluation in hydrophilic interaction liquid chromatography. TALANTA, [PMID:28107907] [10.1016/j.talanta.2016.11.037] |
| 16. Xiuna Jia, Pan Zhao, Xiu Ye, Lianjun Zhang, Ting Wang, Qinyu Chen, Xiaohong Hou. (2016) A novel metal-organic framework composite MIL-101(Cr)@GO as an efficient sorbent in dispersive micro-solid phase extraction coupling with UHPLC-MS/MS for the determination of sulfonamides in milk samples. TALANTA, [PMID:28411816] [10.1016/j.talanta.2016.08.086] |
| 17. Xiangfeng Huang, Yi Feng, Cui Hu, Xiaoyu Xiao, Daliang Yu, Xiaoming Zou. (2015) Mechanistic model for interpreting the toxic effects of sulfonamides on nitrification. JOURNAL OF HAZARDOUS MATERIALS, [PMID:26651069] [10.1016/j.jhazmat.2015.11.037] |
| 18. Yazhen Li, Xuewen Wu, Zhaoqian Li, Shuxian Zhong, Weiping Wang, Aijun Wang, Jianrong Chen. (2015) Fabrication of CoFe2O4–graphene nanocomposite and its application in the magnetic solid phase extraction of sulfonamides from milk samples. TALANTA, [PMID:26452959] [10.1016/j.talanta.2015.08.006] |
| 19. Yong Zhang, Jing Wang, Fubin Liu, Litao Wang, Guihua Gao. (2024) Preparation of cylindrical Chitosan/β-Cyclodextrin/MIL-68(Al) foam column for solid-phase extraction of sulfonamides in water, urine, and milk. JOURNAL OF CHROMATOGRAPHY A, [PMID:38955130] [10.1016/j.chroma.2024.465130] |
| 20. Aolin Ma, Siqi Liu, Zhixuan Du, Longfei Zhu, Guanping Feng. (2025) Sulfonamides impede duckweed growth by inducing an excessive accumulation of salicylic acid. ENVIRONMENTAL AND EXPERIMENTAL BOTANY, [PMID:] [10.1016/j.envexpbot.2025.106224] |
| 21. Qi Mengyu, Tu Chunyan, Li Zhaoqian, Wang Weiping, Chen Jianrong, Wang Ai-Jun. (2018) Determination of Sulfonamide Residues in Honey and Milk by HPLC Coupled with Novel Graphene Oxide/Polypyrrole Foam Material-Pipette Tip Solid Phase Extraction. Food Analytical Methods, 11 (10): (2885-2896). [PMID:] [10.1007/s12161-018-1271-5] |
| 22. Junwei Liu, Xinyue Yang, Tao Gao, Yuehan Zhang, Dandan Pan, Jian He, Xiangwei Wu. (2025) Revealing the anaerobic biodegradation pathway and mechanism of sulfamethoxazole by a novel Cupidesulfovibrio sp. strain SA-9. WATER RESEARCH, [PMID:41389422] [10.1016/j.watres.2025.125118] |
| 23. Huiting Feng, Yuxin Yang, Ruiling Li, Yuting Yang, Zongwen Wang, FengFu Fu, Yue Lin. (2026) Employment of mixed aptamers and gold nanobipyramids toward a paper-based aptasensor for simultaneously visual screening and accurate detection of eight sulfonamides. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, [PMID:] [10.1016/j.saa.2026.127574] |
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