10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Sulindac sulfide is a noncompetitive γ-secretase inhibitor, with an IC 50 of 20.2 μM for γ 42 -secretase activity.
In Vitro
Treatment with 100 μM of Sulindac sulfide (SSide) causes cell death presumably by inducing apoptosis, resulting in marked decrease in Aβgeneration as well as in total protein expression. The IC 50 value for Aβ42 secretion of Sulindac sulfide is 30.6±2.8 μM. SSone and naproxen have no effect either on Aβ40 or Aβ42 secretion as well as on Notch cleavage up to 100 μM. It is observed that an inhibition of γ 42 -secretase activity by Sulindac sulfide in a dose-dependent manner. The IC 50 value of SSide for inhibiting γ 42 -secretase activity in vitro is 20.2±2.6 μM. A decrease is found in slope by the increase of the concentration of SSide in the plot of rate against the enzyme concentration, suggesting that Sulindac sulfide is not an irreversible or pseudo-irreversible inhibitor. Moreover, when the dialyzed solubilizedγ-secretase fraction is pretreated with Sulindac sulfide against CHAPSO buffer without Sulindac sulfide, γ-secretase activity is almost totally recovered. From these data, it is strongly suggested that the genuine molecular target of Sulindac sulfide is the γ-secretase complex and that Sulindac sulfide works as a reversible γ-secretase inhibitor. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
IC50& Target:IC50: 20.2 μM (γ 42 -secretase)
| Isómeros SMILES | CC\1=C(C2=C(/C1=C\C3=CC=C(C=C3)SC)C=CC(=C2)F)CC(=O)O |
|---|---|
| CAS alternativo | 32004-67-4,49627-27-2 |
| PubChem CID | 5352624 |
| Número NSC | 747692 |
| Términos de entrada MeSH | sulindac sulfide;sulindac sulfide, (E)-isomer;sulindac sulfide, (Z)-isomer;sulindac sulfide, sodium salt |
| Peso molecular | 340.41 |
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