Sunitinib Malate - ≥99% , Tyrosine-protein kinase receptor RET inhibitor, CAS No.341031-54-7, Tyrosine-protein kinase receptor RET inhibitor

CAS: 341031-54-7 Cat. No.: E129728 Peso molecular: 532.56 Número EC: 638-825-9

GRADE & PURITY ≥99%

Synonyms

1H-Pyrrole-3-carboxamide, N-(2-(diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-, (2S)-hydroxybutanedioate (1:1) | CAS-341031-54-7 | Sunitinib malate | (Z)-N-(2-(diethylamino)ethyl)-5-((5-fluoro-2-oxoindo

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

Sunitinib is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit.

Specifications

Sinónimos

1H-Pyrrole-3-carboxamide, N-(2-(diethylamino)ethyl)-5-((Z)-(5-fluoro-1, 2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2, 4-dimethyl-, (2S)-hydroxybutanedioate (1:1) | CAS-341031-54-7 | Sunitinib malate | (Z)-N-(2-(diethylamino)ethyl)-5-((5-fluoro-2-oxoindo

Especificaciones y pureza

≥99%

Mecanismos bioquímicos y fisiológicos

Potent, ATP-competitive VEGFR, PDGFRβand KIT inhibitor (Kivalues are 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβand KIT respectively). Also inhibits cellular receptor phosphorylation of FLT3, RET and CSF-1R. Exhibits antiangiogenic and antitumor a

Información jurídica

Sold for only research purposes

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Mecanismo de acción

Tyrosine-protein kinase receptor RET inhibitor

Pureza

≥99%

Nombres e identificadores

• Pubchem Sid: 504764241
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504764241
• Sonrisas canónicas: CCN(CC)CCNC(=O)C1=C(NC(=C1C)C=C2C3=C(C=CC(=C3)F)NC2=O)C.C(C(C(=O)O)O)C(=O)O
• IUPAC Name: N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide;(2S)-2-hydroxybutanedioic acid
• InChIKey: LBWFXVZLPYTWQI-IPOVEDGCSA-N
• INCHI: 1S/C22H27FN4O2.C4H6O5/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28;5-2(4(8)9)1-3(6)7/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28);2,5H,1H2,(H,6,7)(H,8,9)/b17-12-;/t;2-/m.0/s1
• Isómeros SMILES: CCN(CC)CCNC(=O)C1=C(NC(=C1C)/C=C\2/C3=C(C=CC(=C3)F)NC2=O)C.C([C@@H](C(=O)O)O)C(=O)O
• WGK Alemania: 2
• Peso molecular: 532.56
• Reaxy-Rn: 14643863
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=14643863&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Indoles and derivatives
      • Subclass Indolines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Indoles and derivatives
• Subclass: Indolines
• Intermediate Tree Nodes: Not available
• Direct Parent: Indolines
• Alternative Parents: Pyrrole carboxamides Beta hydroxy acids and derivatives Short-chain hydroxy acids and derivatives Substituted pyrroles Aryl fluorides Benzenoids Alpha hydroxy acids and derivatives Dicarboxylic acids and derivatives Fatty acids and conjugates Vinylogous amides Heteroaromatic compounds Amino acids and derivatives Trialkylamines Secondary alcohols Secondary carboxylic acid amides Lactams Carboxylic acids Azacyclic compounds Hydrocarbon derivatives Organofluorides Organopnictogen compounds Carbonyl compounds Organic oxides
• Molecular Framework: Not available
• Substituents: Dihydroindole - Pyrrole-3-carboxamide - Pyrrole-3-carboxylic acid or derivatives - Beta-hydroxy acid - Short-chain hydroxy acid - Alpha-hydroxy acid - Aryl fluoride - Aryl halide - Dicarboxylic acid or derivatives - Hydroxy acid - Fatty acid - Benzenoid - Substituted pyrrole - Heteroaromatic compound - Vinylogous amide - Pyrrole - Amino acid or derivatives - Carboxamide group - Tertiary aliphatic amine - Lactam - Tertiary amine - Secondary carboxylic acid amide - Secondary alcohol - Azacycle - Carboxylic acid - Carboxylic acid derivative - Alcohol - Amine - Hydrocarbon derivative - Organic nitrogen compound - Carbonyl group - Organic oxide - Organohalogen compound - Organofluoride - Organonitrogen compound - Organooxygen compound - Organic oxygen compound - Organopnictogen compound - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as indolines. These are compounds containing an indole moiety, which consists of pyrrolidine ring fused to benzene to form 2,3-dihydroindole.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

CSF1R Tclin Macrophage colony-stimulating factor 1 receptor (1 Activities)

Discover Target: CSF1R

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CSF1R Tclin Macrophage colony stimulating factor receptor (5179 Activities)

Discover Target: CSF1R

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ACHN (49357 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Objetivos asociados (no humanos)

NIH3T3 (5395 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: Solvent:DMSO, Max Conc. mg/mL: 13.31, Max Conc. mM: 25
• Peso molecular: 532.600 g/mol
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 10
• Exact Mass: 532.233 Da
• Monoisotopic Mass: 532.233 Da
• Topological Polar Surface Area: 172.000 Ų
• Heavy Atom Count: 38
• Formal Charge: 0
• Complexity: 765.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 1
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 1
• Covalently-Bonded Unit Count: 2

XLogP3