T-2 Toxin - Moligand™, ≥98% , CAS No.21259-20-1

CAS: 21259-20-1 Cat. No.: T648179 Peso molecular: 466.52 Número EC: 244-297-7

GRADE & PURITY Moligand™, ≥98%

Synonyms

Fusariotoxin T 2 | T-2 Mycotoxin | Mycotoxin T2 | Epoxytrichothecene

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Specifications

Sinónimos

Fusariotoxin T 2 | T-2 Mycotoxin | Mycotoxin T2 | Epoxytrichothecene

Especificaciones y pureza

Moligand™, ≥98%

Mecanismos bioquímicos y fisiológicos

T-2 Toxin (T-2 Mycotoxin) is a toxic trichothecene mycotoxin produced by various Fusarium species in feedstuffs and cereal grains, LD 50 values of T-2 Toxin in mice and rats are 5.2 and 1.5 mg/kg BW a , respectively. T-2 Toxin (T-2 Mycotoxin) can be t

Condiciones de almacenamiento de almacenamiento

Protected from light, Store at -20°C, Argon charged

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Pureza

≥98%

Nombres e identificadores

• Sonrisas canónicas: CC1=CC2C(CC1OC(=O)CC(C)C)(C3(C(C(C(C34CO4)O2)O)OC(=O)C)C)COC(=O)C
• IUPAC Name: [(1S,2R,4S,7R,9R,10R,11S,12S)-11-acetyloxy-2-(acetyloxymethyl)-10-hydroxy-1,5-dimethylspiro[8-oxatricyclo[7.2.1.02,7]dodec-5-ene-12,2'-oxirane]-4-yl] 3-methylbutanoate
• InChIKey: BXFOFFBJRFZBQZ-QYWOHJEZSA-N
• INCHI: 1S/C24H34O9/c1-12(2)7-18(27)32-16-9-23(10-29-14(4)25)17(8-13(16)3)33-21-19(28)20(31-15(5)26)22(23,6)24(21)11-30-24/h8,12,16-17,19-21,28H,7,9-11H2,1-6H3/t16-,17+,19+,20+,21+,22+,23+,24-/m0/s1
• Isómeros SMILES: CC1=C[C@@H]2[C@](C[C@@H]1OC(=O)CC(C)C)([C@]3([C@@H]([C@H]([C@H]([C@@]34CO4)O2)O)OC(=O)C)C)COC(=O)C
• Peso molecular: 466.52

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lipids and lipid-like molecules
    • Clase Prenol lipids
      • Subclass Sesquiterpenoids

• Kingdom: Organic compounds
• Superclass: Lipids and lipid-like molecules
• Clase: Prenol lipids
• Subclass: Sesquiterpenoids
• Intermediate Tree Nodes: Not available
• Direct Parent: Trichothecenes
• Alternative Parents: Tricarboxylic acids and derivatives Oxepanes Fatty acid esters Oxanes Secondary alcohols Cyclic alcohols and derivatives Carboxylic acid esters Oxacyclic compounds Epoxides Dialkyl ethers Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic heteropolycyclic compounds
• Substituents: Trichothecene skeleton - Tricarboxylic acid or derivatives - Fatty acid ester - Oxepane - Oxane - Fatty acyl - Cyclic alcohol - Secondary alcohol - Carboxylic acid ester - Oxacycle - Ether - Oxirane - Dialkyl ether - Carboxylic acid derivative - Organoheterocyclic compound - Hydrocarbon derivative - Organic oxide - Organooxygen compound - Organic oxygen compound - Alcohol - Carbonyl group - Aliphatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as trichothecenes. These are sesquiterpene mycotoxins structurally characterized by the presence of an epoxide ring and a benzopyran derivative with a variant number of hydroxyl, acetyl, or other substituents. The most important structural features causing the biological activities of trichothecenes are the 12,13-epoxy ring, the presence of hydroxyl or acetyl groups at appropriate positions on the trichothecene nucleus and the structure and position of the side-chain.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

K562 (73714 Activities)

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Objetivos asociados (no humanos)

Arabidopsis thaliana (307 Activities)

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Saccharomyces cerevisiae (19171 Activities)

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Triticum aestivum (1582 Activities)

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Gallus gallus (1187 Activities)

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Oryctolagus cuniculus (11301 Activities)

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Mus musculus (284745 Activities)

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Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: DMSO : ≥ 100 mg/mL (214.35 mM)
• Sensibilidad: Moisture and light sensitive
• Peso molecular: 466.500 g/mol
• XLogP3: 0.900
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 9
• Exact Mass: 466.22 Da
• Monoisotopic Mass: 466.22 Da
• Topological Polar Surface Area: 121.000 Ų
• Heavy Atom Count: 33
• Formal Charge: 0
• Complexity: 881.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 8
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referencias

1. Wenting Li, Yongqiang Shi, Xinai Zhang, Xuetao Hu, Xiaowei Huang, Nini Liang, Tingting Shen, Xiaobo Zou, Jiyong Shi.  (2023)  A DNA tetrahedral scaffolds-based electrochemical biosensor for simultaneous detection of AFB1 and OTA.  FOOD CHEMISTRY,      [PMID:38219562] [10.1016/j.foodchem.2023.138312]

2. Mingming Chen, Bihang Su, Huiying Wu, Yawen Dai, Tianwen Chen, Fengfu Fu, Zhenyu Lin, Yongqiang Dong.  (2023)  Hydrogel SERS chip with strong localized surface plasmon resonance for sensitive and rapid detection of T-2 toxin.  TALANTA,      [PMID:37879204] [10.1016/j.talanta.2023.125329]

3. Dongyan Li, Huaiyue Xia, Yingying Sun, Wenjie Liu, Wen Liu, Jianna Yu, Guoxing Jing, Jian Zhang, Wenshan Li.  (2022)  Colorimetric aptasensor for the sensitive detection of ochratoxin A based on a triple cascade amplification strategy.  ANALYTICA CHIMICA ACTA,      [PMID:36442942] [10.1016/j.aca.2022.340616]

4. Kezhuo Zhang, Huadong Cai, Min Lu, Daixian Wei, Jiaqi Yin, Nengshui Ding, Weihua Lai, Juan Peng.  (2022)  Quantum dot nanobead immunochromatographic assay based on bispecific monoclonal antibody for the simultaneous detection of aflatoxin B1 and amantadine.  FOOD AND AGRICULTURAL IMMUNOLOGY,      [PMID:] [10.1080/09540105.2022.2080188]

5. Hualin Guo, Yuhan Sun, Pengfei Ma, Imran Mahmood Khan, Nuo Duan, Zhouping Wang.  (2021)  Sensitive detection of patulin based on DNase Ⅰ-assisted fluorescent aptasensor by using AuNCs-modified truncated aptamer.  FOOD CONTROL,      [PMID:] [10.1016/j.foodcont.2021.108430]

6. Lakshani Madushika, Yongming Huang, Menghan Sun, Yuxuan Liu, Linfang Lu, Xiaoli Li, Na Li, Kang Jiang, Sumei Ling, Shihua Wang.  (2025)  Development of sensitive and rapid immunoassays for Moniliformin (MON) detection based on nanomaterials labeled monoclonal antibodies.  FOOD CHEMISTRY,      [PMID:39842210] [10.1016/j.foodchem.2025.142911]