Talampanel - Moligand™, ≥98%(HPLC) , Glutamate receptor ionotropic, AMPA 1 antagonist, CAS No.161832-65-1, Glutamate receptor ionotropic, AMPA 1 antagonist

CAS: 161832-65-1 Cat. No.: T287576 Peso molecular: 337.37 Número EC: 803-174-3 PubChem CID: 164509

GRADE & PURITY Moligand™, ≥98%(HPLC)

Synonyms

7H-1,3-Dioxolo(4,5-h)(2,3)benzodiazepine, 7-acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-, (R)- | (R)-(-)-1-(4-Aminophenyl)-3-acetyl-4-methyl-7,8-methylenedioxy-3,4-dihydro-5H-2,3-benzodiazepine | SCHEMBL118011 | talampanel(ly300164) | IDR-53773 | Talamp

Storage

Store at 2-8°C

Shipped In

Wet ice

Specifications

Sinónimos

7H-1, 3-Dioxolo(4, 5-h)(2, 3)benzodiazepine, 7-acetyl-5-(4-aminophenyl)-8, 9-dihydro-8-methyl-, (R)- | (R)-(-)-1-(4-Aminophenyl)-3-acetyl-4-methyl-7, 8-methylenedioxy-3, 4-dihydro-5H-2, 3-benzodiazepine | SCHEMBL118011 | talampanel(ly300164) | IDR-53773 | Talamp

Especificaciones y pureza

Moligand™, ≥98%(HPLC)

Mecanismos bioquímicos y fisiológicos

Non-competitive AMPA/kainate receptor antagonist that displays 2.3-3-fold more potent activity thanGYKI 52466. Potentiates the anticonvulsive activity of antiepileptic drugs in animal models of seizures. Orally active.

Condiciones de almacenamiento de almacenamiento

Store at 2-8°C

Enviado en

Wet ice

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

ANTAGONIST

Mecanismo de acción

Glutamate receptor ionotropic, AMPA 1 antagonist

Pureza

≥98%(HPLC)

Propiedades del producto

• ALogP: 2.7

Nombres e identificadores

• Sonrisas canónicas: CC1CC2=CC3=C(C=C2C(=NN1C(=O)C)C4=CC=C(C=C4)N)OCO3
• IUPAC Name: 1-[(8R)-5-(4-aminophenyl)-8-methyl-8,9-dihydro-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-7-yl]ethanone
• InChIKey: JACAAXNEHGBPOQ-LLVKDONJSA-N
• INCHI: 1S/C19H19N3O3/c1-11-7-14-8-17-18(25-10-24-17)9-16(14)19(21-22(11)12(2)23)13-3-5-15(20)6-4-13/h3-6,8-9,11H,7,10,20H2,1-2H3/t11-/m1/s1
• Isómeros SMILES: C[C@@H]1CC2=CC3=C(C=C2C(=NN1C(=O)C)C4=CC=C(C=C4)N)OCO3
• WGK Alemania: 3
• PubChem CID: 164509
• Peso molecular: 337.37

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Benzodiazepines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Benzodiazepines
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Benzodiazepines
• Alternative Parents: Benzodioxoles Aniline and substituted anilines Acetamides Amino acids and derivatives Oxacyclic compounds Azacyclic compounds Acetals Primary amines Organopnictogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Benzodiazepine - Benzodioxole - Aniline or substituted anilines - Monocyclic benzene moiety - Benzenoid - Acetamide - Amino acid or derivatives - Acetal - Carboxylic acid derivative - Oxacycle - Azacycle - Organooxygen compound - Organonitrogen compound - Amine - Carbonyl group - Organic oxide - Organopnictogen compound - Organic oxygen compound - Primary amine - Hydrocarbon derivative - Organic nitrogen compound - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as benzodiazepines. These are organic compounds containing a benzene ring fused to either isomers of diazepine(unsaturated seven-member heterocycle with two nitrogen atoms replacing two carbon atoms).
• External Descriptors: benzodioxoles

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

GRIA2 Tclin Glutamate receptor 2 (0 Activities)

Discover Target: GRIA2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Homo sapiens (32628 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Objetivos asociados (no humanos)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Gallus gallus (1187 Activities)

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Meriones unguiculatus (417 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mus musculus (284745 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: Solvent:DMSO, Max Conc. mg/mL: 33.74, Max Conc. mM: 100
• Peso molecular: 337.400 g/mol
• XLogP3: 2.700
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 337.143 Da
• Monoisotopic Mass: 337.143 Da
• Topological Polar Surface Area: 77.200 Ų
• Heavy Atom Count: 25
• Formal Charge: 0
• Complexity: 544.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1