Talaporfin sodium - ≥99% , Photosensitizing agent, CAS No.220201-34-3, Photosensitizing agent

CAS: 220201-34-3 Cat. No.: T646961 Peso molecular: 799.69

GRADE & PURITY ≥99%

Synonyms

JLWROAPZCOJYGT-OBJGRMLXSA-J | UNII-L63605PZ70 | Aptocine | Talaporfin sodium | Talaporfin tetrasodium salt | LS 11 (photosensitizer) | LS11 | LS-11 | TALAPORFIN TETRASODIUM SALT [MI] | Talaporfinsodium | 4,4'-oxybiphenol | TALAPORFIN SODIUM [WHO-DD] | ME2

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Descripción general

Talaporfin (ME2906) sodium is a chlorin based photosensitizer. Talaporfin sodium can be used for the research of various cancers by using photodynamic therapy (PDT).

In Vivo

Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs) . Labeling in vivo: 1. Use the rat brain tumor model produced by the inoculation of resuspended tumor cells into the frontal rat brain. Feed animals according to your normal protocol. 2. Intravenous injection of 5 mg/kg body weight talaporfin sodium, the concentration of the talaporfin sodium is 5 mg/1 ml 0.9% saline. 3. For the control group, intraperitoneal injection of 100 mg/kg body weight 5-ALA, the concentration of the 5-ALA is 20 mg/1 ml 0.9% saline. 4. Obtain the tissue samples corresponding to the tumor (or edema) brain tissue with 5 mm thickness. 5. The samples are well homogenized with 1 ml of 100% dimethyl sulfoxide (DMSO) and the 100 ul aliquots of the supernatant are put into each well of a 96-well plate. 6. Measure the relative fluorescence intensities of the samples by using a microplate readerin emission wavelength of 670 ±10 nm. The relative fluorescence intensities of the samples (a.u.) were normalized to the relative fluorescence intensities per 1 g-weight of the samples (a.u.). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Rat brain tumor model Dosage: 5 mg/kg Administration: Intravenous injection Result: Showed high fluorescence intensity and retention in brain tumor differentiated from vasogenic edema.

Form:Solid

Specifications

Sinónimos

JLWROAPZCOJYGT-OBJGRMLXSA-J | UNII-L63605PZ70 | Aptocine | Talaporfin sodium | Talaporfin tetrasodium salt | LS 11 (photosensitizer) | LS11 | LS-11 | TALAPORFIN TETRASODIUM SALT [MI] | Talaporfinsodium | 4, 4'-oxybiphenol | TALAPORFIN SODIUM [WHO-DD] | ME2

Especificaciones y pureza

≥99%

Mecanismos bioquímicos y fisiológicos

Talaporfin (ME2906) sodium is a chlorin based photosensitizer . Talaporfin sodium can be used for the research of various cancers by using photodynamic therapy (PDT).

Condiciones de almacenamiento de almacenamiento

Store at 2-8°C, Desiccated

Enviado en

Wet ice

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Mecanismo de acción

Photosensitizing agent

Pureza

≥99%

Nombres e identificadores

• Sonrisas canónicas: CCC1=C(C2=CC3=C(C(=C(N3)C=C4C(C(C(=N4)C(=C5C(=C(C(=N5)C=C1N2)C)C(=O)[O-])CC(=O)NC(CC(=O)[O-])C(=O)[O-])CCC(=O)[O-])C)C)C=C)C.[Na+].[Na+].[Na+].[Na+]
• IUPAC Name: tetrasodium;(2S)-2-[[2-[(2S,3S)-7-carboxylato-3-(2-carboxylatoethyl)-17-ethenyl-12-ethyl-2,8,13,18-tetramethyl-2,3,23,24-tetrahydroporphyrin-5-yl]acetyl]amino]butanedioate
• InChIKey: JLWROAPZCOJYGT-OBJGRMLXSA-J
• INCHI: 1S/C38H41N5O9.4Na/c1-7-20-16(3)24-12-26-18(5)22(9-10-32(45)46)35(42-26)23(11-31(44)41-30(37(49)50)15-33(47)48)36-34(38(51)52)19(6)27(43-36)14-29-21(8-2)17(4)25(40-29)13-28(20)39-24;;;;/h7,12-14,18,22,30,39-40H,1,8-11,15H2,2-6H3,(H,41,44)(H,45,46)(H,47,48)(H,49,50)(H,51,52);;;;/q;4*+1/p-4/t18-,22-,30-;;;;/m0..../s1
• Isómeros SMILES: CCC1=C(C2=CC3=C(C(=C(N3)C=C4[C@H]([C@@H](C(=N4)C(=C5C(=C(C(=N5)C=C1N2)C)C(=O)[O-])CC(=O)N[C@@H](CC(=O)[O-])C(=O)[O-])CCC(=O)[O-])C)C)C=C)C.[Na+].[Na+].[Na+].[Na+]
• CAS alternativo: 220201-34-3,220680-62-6
• Términos de entrada MeSH: laserphyrin;mono-L-aspartyl chlorin e6;monoaspartyl chlorin e6;N-aspartyl chlorin e6;N-aspartylchlorin e6;NPe6;Talaporfin;talaporfin sodium
• Peso molecular: 799.69
• Reaxy-Rn: 14387973
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=14387973&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Tetrapyrroles and derivatives
      • Subclass Chlorins

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Tetrapyrroles and derivatives
• Subclass: Chlorins
• Intermediate Tree Nodes: Not available
• Direct Parent: Chlorins
• Alternative Parents: Aspartic acid and derivatives N-acyl-L-alpha-amino acids Tricarboxylic acids and derivatives Pyrrole carboxylic acids Substituted pyrroles Heteroaromatic compounds Secondary carboxylic acid amides Carboxylic acid salts Azacyclic compounds Carboxylic acids Organic sodium salts Organonitrogen compounds Organic zwitterions Carbonyl compounds Hydrocarbon derivatives Organic oxides
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Chlorin - Aspartic acid or derivatives - N-acyl-alpha-amino acid - N-acyl-alpha amino acid or derivatives - N-acyl-l-alpha-amino acid - Alpha-amino acid or derivatives - Tricarboxylic acid or derivatives - Pyrrole-3-carboxylic acid - Pyrrole-3-carboxylic acid or derivatives - Substituted pyrrole - Heteroaromatic compound - Pyrrole - Carboxamide group - Carboxylic acid salt - Secondary carboxylic acid amide - Organic alkali metal salt - Azacycle - Carboxylic acid - Carboxylic acid derivative - Organic sodium salt - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Organic nitrogen compound - Carbonyl group - Organic salt - Organic zwitterion - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as chlorins. These are large heterocyclic aromatic ring systems consisting, at the core, of three pyrroles and one pyrroline coupled through four methine linkages.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propiedades químicas y físicas

• Solubilidad: H2O : 25 mg/mL (31.26 mM; Need ultrasonic) DMSO : 2 mg/mL (2.50 mM; Need ultrasonic)
• Peso molecular: 799.700 g/mol
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 11
• Rotatable Bond Count: 8
• Exact Mass: 799.218 Da
• Monoisotopic Mass: 799.218 Da
• Topological Polar Surface Area: 247.000 Ų
• Heavy Atom Count: 56
• Formal Charge: 0
• Complexity: 1340.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 3
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 5

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