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DOT1L

DescripciónHistone-lysine N-methyltransferase, H3 lysine-79 specific

Gene and Protein Information

Gene ID84444
Uniprot Accession IDs Q8TEK3 O60379 Q96JL1
Ensembl ID ENSP00000381657
Symbol KIAA1814 KMT4 DOT1 KMT4
FamilyBelongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.
Sequence
MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVLIDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSTGLLRHILQQVYNHSVTDPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTDDDLFVDLGSGVGQVVLQVAAATNCKHHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFVNNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLKGSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRESKSNAATPTKGPEGKVAGPADAPMDSGAEEEKAGAATVKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMNTANPERKPKKNQTALDALHAQTVSQTAASSPQDAYRSPHSPFYQLPPSVQRHSPNPLLVAPTPPALQKLLESFKIQYLQFLAYTKTPQYKASLQELLGQEKEKNAQLLGAAQQLLSHCQAQKEEIRRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQSEQLEQDNRALRGQSLQLLKARCEELQLDWATLSLEKLLKEKQALKSQISEKQRHCLELQISIVELEKSQRQQELLQLKSCVPPDDALSLHLRGKGALGRELEPDASRLHLELDCTKFSLPHLSSMSPELSMNGQAAGYELCGVLSRPSSKQNTPQYLASPLDQEVVPCTPSHVGRPRLEKLSGLAAPDYTRLSPAKIVLRRHLSQDHTVPGRPAASELHSRAEHTKENGLPYQSPSVPGSMKLSPQDPRPLSPGALQLAGEKSSEKGLRERAYGSSGELITSLPISIPLSTVQPNKLPVSIPLASVVLPSRAERARSTPSPVLQPRDPSSTLEKQIGANAHGAGSRSLALAPAGFSYAGSVAISGALAGSPASLTPGAEPATLDESSSSGSLFATVGSRSSTPQHPLLLAQPRNSLPASPAHQLSSSPRLGGAAQGPLPEASKGDLPSDSGFSDPESEAKRRIVFTITTGAGSAKQSPSSKHSPLTASARGDCVPSHGQDSRRRGRRKRASAGTPSLSAGVSPKRRALPSVAGLFTQPSGSPLNLNSMVSNINQPLEITAISSPETSLKSSPVPYQDHDQPPVLKKERPLSQTNGAHYSPLTSDEEPGSEDEPSSARIERKIATISLESKSPPKTLENGGGLAGRKPAPAGEPVNSSKWKSTFSPISDIGLAKSADSPLQASSALSQNSLFTFRPALEEPSADAKLAAHPRKGFPGSLSGADGLSPGTNPANGCTFGGGLAADLSLHSFSDGASLPHKGPEAAGLSSPLSFPSQRGKEGSDANPFLSKRQLDGLAGLKGEGSRGKEAGEGGLPLCGPTDKTPLLSGKAAKARDREVDLKNGHNLFISAAAVPPGSLLSGPGLAPAASSAGGAASSAQTHRSFLGPFPPGPQFALGPMSLQANLGSVAGSSVLQSLFSSVPAAAGLVHVSSAATRLTNSHAMGSFSGVAGGTVGGN
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNombreNIFOther Gene IDSources
Chimp455566DOT1LDOT1 like histone lysine methyltransferase9598VGNC:7478OMA, EggNOG
Macaque710033DOT1LDOT1 like histone lysine methyltransferase9544Inparanoid, OMA, EggNOG
Mouse208266Dot1lDOT1-like, histone H3 methyltransferase (S. cerevisiae)10090MGI:2143886Inparanoid, OMA, EggNOG
Rat362831Dot1lDOT1 like histone lysine methyltransferase10116RGD:1306644Inparanoid, OMA, EggNOG
Dog485073DOT1LDOT1 like histone lysine methyltransferase9615VGNC:54298Inparanoid, OMA, EggNOG
Horse100068506DOT1LDOT1 like histone lysine methyltransferase9796VGNC:50588Inparanoid, OMA, EggNOG
Cow510442DOT1LDOT1 like histone lysine methyltransferase9913VGNC:50607OMA, EggNOG
Pig100738665DOT1LDOT1 like histone lysine methyltransferase9823OMA, EggNOG
Opossum100619840DOT1LDOT1 like histone lysine methyltransferase13616Inparanoid, OMA, EggNOG
Chicken420078DOT1LDOT1 like histone lysine methyltransferase9031CGNC:549OMA, EggNOG
Xenopusdot1lDOT1-like histone H3K79 methyltransferase [Source:Xenbase;Acc:XB-GENE-6033925]8364OMA, EggNOG
Zebrafish559945dot1lDOT1-like histone H3K79 methyltransferase7955ZDB-GENE-060503-341Inparanoid, OMA, EggNOG
Fruitfly40793gppgrappa7227FBgn0264495Inparanoid, EggNOG

Protein Classes

PANTHER Classes
protein    /    transferase    /    methyltransferase    /    Histone-lysine N-methyltransferase, H3 lysine-79 specific
DTO Classes
protein    /    Epigenetic regulator    /    Writer    /    Protein methyltransferase    /    Histone-lysine N-methyltransferase, H3 lysine-79 specific

Associated Recombinant Proteins

NombreSpecification and purityExpression systemProtein labelDisponibilidadMostrar detalles

Associated Antibodies

NombreSpecificationsSpecies reactivityAplicaciónDisponibilidadMostrar detalles

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NombreDirect Associated TargetsDisease TypeMondoid

      Bibliography

      🔙[Back to Target (Human)]
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