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NPC1

DescripciónNPC intracellular cholesterol transporter 1

Gene and Protein Information

Gene ID4864
Uniprot Accession IDs O15118 B4DET3 Q9P130
Ensembl ID ENSP00000269228
Symbol NPC POGZ SLC65A1
FamilyBelongs to the patched family.
Sequence
MTARGLALGLLLLLLCPAQVFSQSCVWYGECGIAYGDKRYNCEYSGPPKPLPKDGYDLVQELCPGFFFGNVSLCCDVRQLQTLKDNLQLPLQFLSRCPSCFYNLLNLFCELTCSPRQSQFLNVTATEDYVDPVTNQTKTNVKELQYYVGQSFANAMYNACRDVEAPSSNDKALGLLCGKDADACNATNWIEYMFNKDNGQAPFTITPVFSDFPVHGMEPMNNATKGCDESVDEVTAPCSCQDCSIVCGPKPQPPPPPAPWTILGLDAMYVIMWITYMAFLLVFFGAFFAVWCYRKRYFVSEYTPIDSNIAFSVNASDKGEASCCDPVSAAFEGCLRRLFTRWGSFCVRNPGCVIFFSLVFITACSSGLVFVRVTTNPVDLWSAPSSQARLEKEYFDQHFGPFFRTEQLIIRAPLTDKHIYQPYPSGADVPFGPPLDIQILHQVLDLQIAIENITASYDNETVTLQDICLAPLSPYNTNCTILSVLNYFQNSHSVLDHKKGDDFFVYADYHTHFLYCVRAPASLNDTSLLHDPCLGTFGGPVFPWLVLGGYDDQNYNNATALVITFPVNNYYNDTEKLQRAQAWEKEFINFVKNYKNPNLTISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHMKSCRRLLVDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAYQRDERLQGETLDQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQEKNRLDIFCCVRGAEDGTSVQASESCLFRFFKNSYSPLLLKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYFKSISQYLHAGPPVYFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQIFNAAQLDNYTRIGFAPSSWIDDYFDWVKPQSSCCRVDNITDQFCNASVVDPACVRCRPLTPEGKQRPQGGDFMRFLPMFLSDNPNPKCGKGGHAAYSSAVNILLGHGTRVGATYFMTYHTVLQTSADFIDALKKARLIASNVTETMGINGSAYRVFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWSAVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEEALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLSYIGPSVNKAKSCATEERYKGTERERLLNF
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNombreNIFOther Gene IDSources
Chimp455338NPC1NPC intracellular cholesterol transporter 19598VGNC:10461OMA, EggNOG
Macaque700835NPC1NPC intracellular cholesterol transporter 19544OMA, EggNOG
Mouse18145Npc1NPC intracellular cholesterol transporter 110090MGI:1097712Inparanoid, OMA, EggNOG
Rat266732Npc1NPC intracellular cholesterol transporter 110116RGD:628693Inparanoid, OMA, EggNOG
Dog403698NPC1NPC intracellular cholesterol transporter 19615VGNC:43913Inparanoid, OMA, EggNOG
Horse100059175NPC1NPC intracellular cholesterol transporter 19796VGNC:20831Inparanoid, OMA, EggNOG
Cow286772NPC1NPC intracellular cholesterol transporter 19913VGNC:32194Inparanoid, OMA, EggNOG
Pig397591NPC1NPC intracellular cholesterol transporter 19823Inparanoid, OMA, EggNOG
Opossum100011777NPC1NPC intracellular cholesterol transporter 113616Inparanoid, OMA, EggNOG
Platypus100092266NPC1NPC intracellular cholesterol transporter 19258Inparanoid, OMA, EggNOG
Chicken421076NPC1NPC intracellular cholesterol transporter 19031CGNC:11176Inparanoid, OMA, EggNOG
Anole lizard100561824npc1NPC intracellular cholesterol transporter 128377Inparanoid, OMA, EggNOG
Xenopusnpc1NPC intracellular cholesterol transporter 1 [Source:Xenbase;Acc:XB-GENE-984654]8364OMA, EggNOG
Zebrafish553330npc1Niemann-Pick disease, type C17955ZDB-GENE-030131-3161Inparanoid, OMA, EggNOG
C. elegans176165ncr-2Niemann-Pick C1 protein homolog 26239OMA, EggNOG
Fruitfly34358Npc1aNiemann-Pick type C-1a7227FBgn0024320Inparanoid, EggNOG
S.cerevisiae856101NCR1sphingolipid transporter4932S000005927OMA, EggNOG

Protein Classes

DTO Classes
protein    /    Transporter    /    SLC superfamily of solute carriers    /    SLC65 NPC-type cholesterol transporters    /    Niemann-Pick C1 protein

Associated Recombinant Proteins

NombreSpecification and purityExpression systemProtein labelDisponibilidadMostrar detalles

Associated Antibodies

NombreSpecificationsSpecies reactivityAplicaciónDisponibilidadMostrar detalles

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NombreDirect Associated TargetsDisease TypeMondoid

      Bibliography

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