TD52 dihydrochloride - ≥99% , CAS No.T659333

CAS: T659333 Cat. No.: T659333 Peso molecular: 433.33

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

TD52 dihydrochloride, an Erlotinib ( HY-50896 ) derivative, is an orally active, potent cancerous inhibitor of protein phosphatase 2A (CIP2A) inhibitor. TD52 dihydrochloride mediates the apoptotic effect in triple-negative breast cancer (TNBC) cells via r

Appearance:Solid

In Vitro:TD52 dihydrochloride (2-10 μM; 48 hours) shows anti-proliferative ability and induces differential apoptotic effects in these cell lines. TD52 dihydrochloride (5 μM; 48 hours) has minimal effects on p-EGFR or EGFR expression but downregulated CIP2A e

In Vivo:TD52 dihydrochloride (10mg/kg/day; oral gavage; for 52 days) significantly inhibits MDA-MB-468 xenograft tumour size and tumour weight. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Biological Activity:TD52 dihydrochloride, an Erlotinib ( HY-50896 ) derivative, is an orally active, potent cancerous inhibitor of protein phosphatase 2A (CIP2A) inhibitor. TD52 dihydrochloride mediates the apoptotic effect in triple-negative breast cancer (TNBC) cells via r

Specifications

Especificaciones y pureza

≥99%

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Pureza

≥99%

Nombres e identificadores

• Sonrisas canónicas: C#CC1=CC(NC2=NC3=CC=CC=C3N=C2NC4=CC=CC(C#C)=C4)=CC=C1.[H]Cl.[H]Cl
• Peso molecular: 433.33

Propiedades químicas y físicas

• Solubilidad: DMSO : 25 mg/mL (57.69 mM; ultrasonic and warming and heat to 60°C)