Tempol - 10mM in DMSO , CAS No.2226-96-2

CAS: 2226-96-2 Cat. No.: T407895 Peso molecular: 172.24 Beilstein Registry Number: 1422990 Número EC: 218-760-9

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Tempol (4-Hydroxy-TEMPO) is a superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects. Phase 2.
In vitro

Tempol (4-Hydroxy-TEMPO) is a stable, cell-permeable nitroxide that acts as a free radical scavenger and nitric oxide spin trap. Tempol Exhibits radio-protective and anti-proliferative properties. Tempol inhibits oxygen-dependent radiation-induced damage. ^[1] Tempol induces oxidative stress and enhances the levels of p21WAF1 in HL-60 cells in a dose-dependent manner. ^[2]

In vivo

Tempol reduces oxidant stress-mediated renal dysfunction and injury in the rat. ^[3] Tempol prevents cerebral vessel remodeling in hypertensive rats. ^[4] Tempol lowers blood pressure and sympathetic nerve activity but not vascular O2- in DOCA-salt rats. ^[5] Tempol restores mitochondrial and cardiac functions in TNFα-induced oxidative stress and reduces cardiac hypertrophy in chronic hypoxic rats. ^[6]
Cell Data

cell lines：

Concentrations：', 'Concentrations': '

0.05–1.6 mM

Incubation Time：

Powder Purity:

Specifications

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Membrane permeable superoxide scavenger. SOD simulation. Reduce inflammation caused by superoxide anions and peroxynitrite. Reduce oxidative stress.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Nombres e identificadores

• Isómeros SMILES: CC1(CC(CC(N1[O])(C)C)O)C
• WGK Alemania: 1
• RTECS: TN8991000
• Peso molecular: 172.24
• Beilstein: 1422990
• Reaxy-Rn: 11328213

Propiedades químicas y físicas

• Punto de inflamación (°F): 294.80℉
• Punto de inflamación (°C): 146℃
• Punto de fusión (°C): 69-71°C

Referencias

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65. Jiaxin Xu, Xiuquan Lan, Jianhua Cheng, Xinhui Zhou.  (2022)  Facile synthesis of g-C3N4/Ag2C2O4 heterojunction composite membrane with efficient visible light photocatalytic activity for water disinfection.  CHEMOSPHERE,      [PMID:35131277] [10.1016/j.chemosphere.2022.133841]

66. Yanzhuo Zhang, Mengqi Xu, Rui He, Jing Zhao, Wei Kang, Jinghua Lv.  (2022)  Effect of pyrolysis temperature on the activated permonosulfate degradation of antibiotics in nitrogen and sulfur-doping biochar: Key role of environmentally persistent free radicals.  CHEMOSPHERE,      [PMID:35090846] [10.1016/j.chemosphere.2022.133737]

67. Tianyou Chen, Wei Xiao, Zihao Wang, Pengfei Gan, Changfeng Yi, Zushun Xu.  (2021)  Pyrene-Containing Polymer-Supported Cu/TEMPO Catalytic Systems: Aromatic Stacking-Enhanced Cooperative Catalysis.  Journal of Physical Chemistry C,      [PMID:] [10.1021/acs.jpcc.1c09972]

68. Ningning Dong, Lifa Ge, Pei Chen, Wei Wang, Fatang Tan, Xinyun Wang, Xueliang Qiao, Po Keung Wong.  (2021)  Non-radical activation of CaO2 nanoparticles by MgNCN/MgO composites for efficient remediation of organic and heavy metal-contaminated wastewater.  SEPARATION AND PURIFICATION TECHNOLOGY,      [PMID:] [10.1016/j.seppur.2021.120334]

69. Xiaotong Fu, Fulong Zhang, Cuihua Dong, Wenyuan Zhu, Kaifeng Xiong, Zhiqiang Pang.  (2021)  Efficient homogeneous TEMPO-mediated oxidation of cellulose in lithium bromide hydrates.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:34571122] [10.1016/j.ijbiomac.2021.09.104]

70. Xiaoshan Fan, Lingjie Ke, Hongwei Cheng, Hu Chen, Zhiguo Li, Enyi Ye, Xian-Jun Loh, Yun-Long Wu, Gang Liu, Zibiao Li.  (2021)  Enhanced drug retention by anthracene crosslinked nanocomposites for bimodal imaging-guided phototherapy.  Nanoscale,  13  (35): (14713-14722).  [PMID:34473183] [10.1039/D1NR04171A]

71. Lifen Wang, Yonggang Liu, Yinjun Lin, Yonghao Yu, Xueying Zhang, Ruiqin Zhang, Yunpu Zhai.  (2021)  One-step synthesis of novel Ni-doped Cu2(OH)3F Fenton-like catalyst driven by visible light: Single activity and synergistic effect enhanced by bimetallic cooperation.  JOURNAL OF ALLOYS AND COMPOUNDS,      [PMID:] [10.1016/j.jallcom.2021.161424]

72. Xiao Li, Xiaomei Wu, Tao Yuan, Junrun Zhu, Yaling Yang.  (2021)  Influence of the iodine content of nitrogen- and iodine-doped carbon dots as a peroxidase mimetic nanozyme exhibiting antifungal activity against C. albicans.  BIOCHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.bej.2021.108139]

73. Xiaohui Wu, Leitao Cao, Jun Song, Yang Si, Jianyong Yu, Bin Ding.  (2019)  Thorn-like flexible Ag2C2O4/TiO2 nanofibers as hierarchical heterojunction photocatalysts for efficient visible-light-driven bacteria-killing.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,      [PMID:31706650] [10.1016/j.jcis.2019.10.119]

74. Jun Song, Jianyong Yu, Gang Sun, Yang Si, Bin Ding.  (2019)  Visible-light-driven, hierarchically heterostructured, and flexible silver/bismuth oxyiodide/titania nanofibrous membranes for highly efficient water disinfection.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,      [PMID:31408762] [10.1016/j.jcis.2019.08.017]

75. Xianhua Hou, Zishuai Zhang, Kaixiang Shen, Shikun Cheng, Qinyu He, Yumeng Shi, Denis Y. W. Yu, Ching-yuan Su, Lain-Jong Li, Fuming Chen.  (2019)  An Aqueous Rechargeable Fluoride Ion Battery with Dual Fluoride Electrodes.  JOURNAL OF THE ELECTROCHEMICAL SOCIETY,  166  (12): (A2419).  [PMID:] [10.1149/2.0301912jes]

76. Xinbo Jing, Xueying Peng, Xiyin Sun, Wu Zhou, Wei Wang, Shufen Wang.  (2019)  Design and synthesis of Mo2C/MoO3 with enhanced visible-light photocatalytic performance for reduction of Cr (VI) and degradation of organic pollutants.  MATERIALS SCIENCE IN SEMICONDUCTOR PROCESSING,      [PMID:] [10.1016/j.mssp.2019.05.004]

77. Liu Shaojie, Sun Tingting, Yang Desheng, Cao Meng, Liang Huazhe.  (2018)  Polyacrylic acid supported TEMPO for selective catalytic oxidation of cellulose: recovered by its pH sensitivity.  CELLULOSE,  25  (10): (5687-5696).  [PMID:] [10.1007/s10570-018-2012-z]

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81. Yuxin Liu, Qintie Lin, Jieyi Pan, Yirong Deng, Junli Zheng, Mingchao Lyu, Hao Luo, Yang Luo.  (2024)  A nitrogen-enriched strategy to accelerate the remediation of Cr(VI)-contaminated soil by iron-based materials in microwave fields.  JOURNAL OF HAZARDOUS MATERIALS,      [PMID:39504776] [10.1016/j.jhazmat.2024.136399]

82. Md Alim Uddin, Yihua Shen, Li Wang, Haojie Yu, Huanan Wang, Xunchun Yuan, Abdul Basit, Muhammad Owais Malik, Khan Manqoosh Awan, Lichang Xu, Xiwang Yuan, Qiang Li.  (2025)  All-Organic Pectin-Nitroxide Nanoconjugates as Biocompatible and Metal-Free Magnetic Resonance Imaging Contrast Agents.  ACS Applied Polymer Materials,      [PMID:] [10.1021/acsapm.4c03374]

83. Shuo Yang, Wenhui Li, Kaiyue Li, Ping Huang, Yuquan Zhuo, Keyan Liu, Ziwen Yang, Donglai Han.  (2024)  Engineering n-Type and p-Type BiOI Nanosheets: Influence of Mannitol on Semiconductor Behavior and Photocatalytic Activity.  Nanomaterials,  14  (24): (2048).  [PMID:39728584] [10.3390/nano14242048]

84. Yinglai Hou, Zhizhi Sheng, Mengchuang Zhang, Kaifa Lin, Jie Kong, Xuetong Zhang.  (2024)  Hierarchically Porous Carbon Colloidal Aerogels for Highly Efficient Flow Cells.  ADVANCED FUNCTIONAL MATERIALS,      [PMID:] [10.1002/adfm.202418721]

85. Lan Qing, Jin Su-Juan, Liu Ying, Jin Xiao-Li, Xie Hai-Quan, Li Yu-Zhu, Liu Ke-Cheng, Chen Li.  (2024)  Highly effective photocatalytic decomposition of tetracycline and reduction of Cr(VI) under visible light using Ag/polyoxometalate composite nanomaterials prepared by a mild grinding method.  Tungsten,      [PMID:] [10.1007/s42864-024-00301-0]

86. Ningxuan Xue, Zhaobing Guo, Xinyu Gai, Yiyang Chen, Siyue He, Guanjie Lin, Fengling Liu, Shuai Zhang, Pengxiang Qiu.  (2024)  Insight on the optimized electronic structure of carbon nitride on ultrafast water treatment via photocatalytic activation of ferrate.  JOURNAL OF HAZARDOUS MATERIALS,      [PMID:39742859] [10.1016/j.jhazmat.2024.137029]

87. Shuo Yang, Tianna Wu, Kaiyue Li, Ping Huang, Wenhui Li, Yuquan Zhuo, Keyan Liu, Ziwen Yang, Donglai Han.  (2024)  Photocatalytic Enhancement and Recyclability in Visible-Light-Responsive 2D/2D g-C3N4/BiOI p-n Heterojunctions via a Z-Scheme Charge Transfer Mechanism.  MOLECULES,  29  (22): (5418).  [PMID:39598807] [10.3390/molecules29225418]

88. Jiwen Li, Yaqian Duan, Linlin Wang, Jingjun Ma.  (2024)  Preparation of core-shell structure Ag@TiO2 plasma photocatalysts and reduction of Cr(VI): Size dependent and LSPR effect.  ENVIRONMENTAL RESEARCH,      [PMID:38266898] [10.1016/j.envres.2024.118265]

89. Han Donglai, Guo Boyang, Li Yanru, Feng Wei, Liu Keyan, Wu Tianna, Wan Yuchun, Wang Lili, Gao Ming, Liu Yang, Yang Lili, Wei Maobin, Yang Shuo.  (2024)  Simultaneous photocatalytic degradation and SERS detection of tetracycline with self-sustainable and recyclable ternary PI/TiO2/Ag flexible microfibers.  Microsystems & Nanoengineering,  10  (1): (1-13).  [PMID:38505466] [10.1038/s41378-023-00624-x]

90. Feng Feng, Jiaying Zhang, Lu Yu, Haixin Wang, Heda Ding, Jifan Cheng, Miaolan Wang, Fangfang Chen, Jiahui Zhang, Lingling Guo, Chunshan Lu, Qunfeng Zhang, Xiaonian Li.  (2025)  Study on the dissolution of precious metals in the nitrogrn-oxygen free radical ionic liquid system.  Journal of Environmental Chemical Engineering,      [PMID:] [10.1016/j.jece.2025.115739]

91. Li Suiqin, Wang Shibin, Wang Yuhang, He Jiahui, Li Kai, Gerken James B., Stahl Shannon S., Zhong Xing, Wang Jianguo.  (2025)  Synergistic enhancement of electrochemical alcohol oxidation by combining NiV-layered double hydroxide with an aminoxyl radical.  Nature Communications,  16  (1): (1-14).  [PMID:39747151] [10.1038/s41467-024-55616-w]

92. Xinyu Gai, Ningxuan Xue, Pengxiang Qiu, Yiyang Chen, Da Teng, Zhihui Zhang, Fengling Liu, Zhongyi Liu, Zhaobing Guo.  (2025)  Insight on the Ultrafast Water Treatment over NiFe-Layered Double Hydroxides via Electroactivation of Ferrate(VI): The Role of Spin State Regulation.  Water,  17  (9): (1369).  [PMID:] [10.3390/w17091369]

93. Jiayu Gu, Mingzhou Wu, Linlin Wang, Fengling Liu, Suhao He, Minrui Ding, Yuye Yao, Neng Tao, Haitao Sha, Zhaobing Guo, Huimin Zhou, Pin Zhou, Pengxiang Qiu.  (2025)  Bromine-doped Bi2MoO6 nanosheets: synergistic effects of band structure engineering and oxygen vacancy regulation for boosting photocatalytic activity.  JOURNAL OF MOLECULAR STRUCTURE,      [PMID:] [10.1016/j.molstruc.2025.142775]

94. Qian Tang, Yixin Fan, Yin Zhu, Kai Wu, Jialin Song, Yuwei Sun, Yonghui Gao.  (2025)  Anchoring CoFe2O4 nanoparticles on ZnO for enhanced peroxymonosulfate activation in tetracycline degradation: Performance, mechanism and degradation pathway.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,      [PMID:] [10.1016/j.colsurfa.2025.138709]

95. Yuxin Zheng, Kamile Arkin, Yuting Xu, Xue Jiang, Ning Xu, Qingkun Shang.  (2025)  Design and application of ratiometric room temperature phosphorescent probes based on triplet-singlet Fӧrster resonance energy transfer mechanism between silica-coated phosphorescent carbon dots and rhodamine 6G.  CARBON,      [PMID:] [10.1016/j.carbon.2025.120954]

96. Mengge Yan, Tingting Liu, Yushan Hu, Wenlong Bai, Mingfei Wei, Yuxuan Zhang, Xusheng He, Ru Li.  (2026)  Construction of WO3/ZnIn2S4 Z-scheme heterojunction by electrostatic self-assembly to enhance charge separation and reactive oxygen species generation.  Journal of Water Process Engineering,      [PMID:] [10.1016/j.jwpe.2026.109445]

97. Da Teng, Pengxiang Qiu, Yingying Xu, Chunjie Zhu, Xiu Zhang, Leyi Liu, Chen Wei, Yalin Yu, Ningxuan Xue, Xinyu Gai, Yiyang Chen, Siyue He, Guanjie Lin, Fengling Liu, Jiayu Gu, Shuai Zhang, Zhaobing Guo.  (2026)  Carbon Nanotube-Engineered Electron Transfer Pathways in NiFe-LDH for Enhanced Photocatalytic Ferrate Activation.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,      [PMID:] [10.1016/j.colsurfa.2026.139841]

98. Wang Hanlin, Chu Ziyang, Li Mengxue, Chen Tianhu.  (2026)  Green preparation of pyrrhotite-activated H2O2 for tetracycline degradation: performance and mechanism.  WATER SCIENCE AND TECHNOLOGY,  93  (3): (318-331).  [PMID:41686499] [10.2166/wst.2026.203]