Tetrahydrobiopterin - Moligand™, ≥98% , Activator of L-Phenylalanine hydroxylase , CAS No.17528-72-2, Activator of L-Phenylalanine hydroxylase

CAS: 17528-72-2 Cat. No.: T305191 Peso molecular: 241.25

GRADE & PURITY Moligand™, ≥98%

Synonyms

tetrahydrobiopterin | HY-107383 | 1-(2-amino-4-hydroxy-5,6,7,8-tetrahydropteridin-6-yl)propane-1,2-diol | 5-26-18-00418 (Beilstein Handbook Reference) | FT-0700530 | L-erythro-2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4(3H)-pteridinon | Q61014518

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Descripción general

Tetrahydrobiopterin ((Rac)-Sapropterin) is a cofactor of the aromatic amino acid hydroxylases enzymes and also acts as an essential cofactor for all nitric oxide synthase (NOS) isoforms.

Specifications

Sinónimos

tetrahydrobiopterin | HY-107383 | 1-(2-amino-4-hydroxy-5, 6, 7, 8-tetrahydropteridin-6-yl)propane-1, 2-diol | 5-26-18-00418 (Beilstein Handbook Reference) | FT-0700530 | L-erythro-2-Amino-6-(1, 2-dihydroxypropyl)-5, 6, 7, 8-tetrahydro-4(3H)-pteridinon | Q61014518

Especificaciones y pureza

Moligand™, ≥98%

Condiciones de almacenamiento de almacenamiento

Protected from light, Store at -20°C, Argon charged

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

ACTIVATOR

Mecanismo de acción

Activator of L-Phenylalanine hydroxylase

Pureza

≥98%

Nombres e identificadores

• Sonrisas canónicas: CC(C(C1CNC2=C(N1)C(=O)NC(=N2)N)O)O
• IUPAC Name: 2-amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-3H-pteridin-4-one
• InChIKey: FNKQXYHWGSIFBK-UHFFFAOYSA-N
• INCHI: 1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17)
• Isómeros SMILES: CC(C(C1CNC2=C(N1)C(=O)NC(=N2)N)O)O
• CAS alternativo: 69056-38-8
• Peso molecular: 241.25

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Pteridines and derivatives
      • Subclass Pterins and derivatives

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Pteridines and derivatives
• Subclass: Pterins and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Biopterins and derivatives
• Alternative Parents: Secondary alkylarylamines Pyrimidones Aminopyrimidines and derivatives Vinylogous amides Heteroaromatic compounds 1,3-aminoalcohols Secondary alcohols 1,2-diols 1,2-aminoalcohols Azacyclic compounds Primary amines Organopnictogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Biopterin - Aminopyrimidine - Pyrimidone - Secondary aliphatic/aromatic amine - Pyrimidine - 1,3-aminoalcohol - Vinylogous amide - Heteroaromatic compound - Secondary alcohol - 1,2-diol - 1,2-aminoalcohol - Secondary amine - Azacycle - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Primary amine - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Organic nitrogen compound - Amine - Alcohol - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as biopterins and derivatives. These are coenzymes containing a 2-amino-pteridine-4-one derivative. They are mainly synthesized in several parts of the body, including the pineal gland.
• External Descriptors: a biopterin

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

PAH Tclin Phenylalanine-4-hydroxylase (1 Activities)

Discover Target: PAH

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Sensibilidad: light sensitive，air sensitive
• Peso molecular: 241.250 g/mol
• XLogP3: -1.900
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 2
• Exact Mass: 241.117 Da
• Monoisotopic Mass: 241.117 Da
• Topological Polar Surface Area: 132.000 Ų
• Heavy Atom Count: 17
• Formal Charge: 0
• Complexity: 405.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 3
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referencias

1. Ai Yulin, Huang Yusong, Zhao Hongru, Su Bingmei, Lin Juan.  (2025)  Engineered phenylalanine hydroxylase coupled with an effective cofactor synthesis and regeneration system for high-yield production of 5-hydroxytryptophan.  Bioresources and Bioprocessing,  12  (1): (1-14).  [PMID:40047997] [10.1186/s40643-025-00846-z]