Tetrandrine (NSC-77037) - Moligand™, 10mM in DMSO , CAS No.518-34-3

CAS: 518-34-3 Cat. No.: T407742 Peso molecular: 622.75 Beilstein Registry Number: 877811 Número EC: 683-095-7

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

Fanchinine, d-Tetrandrine | 16H-1,24:6,9-Dietheno-11,15-metheno-2H-pyrido[2',3':17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinoline, 3,4,4a,5,16a,17,18,19-octahydro-12,21,22,26-tetramethoxy-4,17-dimethyl-, (4aS,16aS)-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Tetrandrine (NSC-77037) Tetrandrine (NSC-77037, Fanchinine, d-Tetrandrine), a bis-benzylisoquinoline alkaloid derived from Stephania tetrandra, is a calcium channel blocker.
In vitro

Tetrandrine inhibits voltage-gated Ca2+ currents with an IC50 of 10.1 mM in isolated nerve terminals of the rat neurohypophysis. Tetrandrine is a high-affinity blocker of the type II, maxi-Ca(2+)-activated K+ channel of the rat neurohypophysial terminals with an IC50 of 0.21 mM. Another study shows that Tetrandrine also inhibits Ca(2+)-activated Cl- currents (I(Cl,Ca)) with an IC50 of 5.2 mM. Tetrandrine inhibits the proliferation of human leukemic HL-60 cells via induction of apoptosis.

In vivo

LD50: Mice 158.9mg/kg (i.v.) , 365mg/kg (i.p.) ; Rats 646mg/kg (i.g.)
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥98%

Specifications

Sinónimos

Fanchinine, d-Tetrandrine | 16H-1, 24:6, 9-Dietheno-11, 15-metheno-2H-pyrido[2', 3':17, 18][1, 11]dioxacycloeicosino[2, 3, 4-ij]isoquinoline, 3, 4, 4a, 5, 16a, 17, 18, 19-octahydro-12, 21, 22, 26-tetramethoxy-4, 17-dimethyl-, (4aS, 16aS)-

Especificaciones y pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Tetrandrine (NSC-77037, Fanchinine, d-Tetrandrine), a bis-benzylisoquinoline alkaloid derived from Stephania tetrandra, is a calcium channel blocker.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Nombres e identificadores

• Isómeros SMILES: CN1CCC2=CC(=C3C=C2[C@@H]1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)C[C@H]6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)OC)OC
• WGK Alemania: 3
• RTECS: XE9350000
• Peso molecular: 622.75
• Beilstein: 877811
• Reaxy-Rn: 79005
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=79005&ln=

Propiedades químicas y físicas

• Punto de fusión (°C): 219-222°C

Referencias

1. Wenqian Shang, Jing Zhang, Haibo Song, Shunfei Zhu, Aimin Zhang, Yushuang Hua, Shujun Han, Yan Fu.  (2021)  Mechanism of Tetrandrine Against Endometrial Cancer Based on Network Pharmacology.  Drug Design Development and Therapy,      [PMID:34262258] [10.2147/DDDT.S307670]

2. Zhou Yufeng, Duan Liguang, Huang Yixin, Liu Yaqi, Wang Lijuan, Qiao Xiaoqiang.  (2021)  Ionic Liquid 1-Vinyl-3-dodecylimidazole Bromide Embedded Hybrid Monolithic Column and Its Versatile Post-modification with Amino Acids.  Journal of Analysis and Testing,  5  (4): (387-395).  [PMID:] [10.1007/s41664-021-00171-2]

3. Liu Mingyang, Du Xuejun, Xu Ke, Yan Binwei, Fan Zaibi, Gao Zideng, Ren Xueqin.  (2021)  A cationic quantum dot-based ratiometric fluorescent probe to visually detect berberine hydrochloride in human blood serums.  Journal of Analytical Science and Technology,  12  (1): (1-9).  [PMID:] [10.1186/s40543-021-00261-x]

4. Yan Li, Shuai Wang, Fang Xiang Song, Li Zhang, Wei Yang, Hong Xia Wang, Qian Lin Chen.  (2020)  A pH-sensitive drug delivery system based on folic acid-targeted HBP-modified mesoporous silica nanoparticles for cancer therapy.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,      [PMID:] [10.1016/j.colsurfa.2020.124470]

5. Qing Wang, Ling Tong, Lin Yao, Peng Zhang, Li Xu.  (2016)  Fingerprinting of traditional Chinese medicines on the C18-Diol mixed-mode column in online or offline two-dimensional liquid chromatography on the single column modes.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,      [PMID:27031576] [10.1016/j.jpba.2016.03.033]

6. Qing Wang, Yao Long, Lin Yao, Li Xu, Zhi-Guo Shi, Lanying Xu.  (2015)  Preparation, characterization and application of a reversed phase liquid chromatography/hydrophilic interaction chromatography mixed-mode C18-DTT stationary phase.  TALANTA,      [PMID:26695288] [10.1016/j.talanta.2015.09.009]

7. Qing Wang, Zhi-Yuan Luo, Mao Ye, Yu-Zhuo Wang, Li Xu, Zhi-guo Shi, Lanying Xu.  (2015)  Preparation, chromatographic evaluation and application of adenosine 5′-monophosphate modified ZrO2/SiO2 stationary phase in hydrophilic interaction chromatography.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:25627970] [10.1016/j.chroma.2015.01.017]

8. Zhisheng Xie, Xinjun Xu, Chunyan Xie, Zhikun Liang, Mei Yang, Jieyun Huang, Depo Yang.  (2014)  PREPARATIVE ISOLATION OF TETRANDRINE AND FANGCHINOLINE FROM RADIX STEPHANIA TETRANDRA USING REVERSED-PHASE FLASH CHROMATOGRAPHY.  JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES,      [PMID:] [10.1080/10826076.2012.745139]

9. Ruan Lin, Huang Huan-Sen, Jin Wen-Xiang, Chen Hai-Ming, Li Xiong-Juan, Gong Qing-Juan.  (2013)  Tetrandrine Attenuated Cerebral Ischemia/Reperfusion Injury and Induced Differential Proteomic Changes in a MCAO Mice Model Using 2-D DIGE.  NEUROCHEMICAL RESEARCH,  38  (9): (1871-1879).  [PMID:23780673] [10.1007/s11064-013-1093-1]

10. Lihong Liu, Shenglan Li, Zilin Chen.  (2011)  Simultaneous determination of tetrandrine and fangchinoline in herbal medicine Stephania tetrandra S. Moore by liquid chromatography with electrochemical detection.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,      [PMID:22196802] [10.1016/j.jpba.2011.11.027]

11. Yunyan Chen, Ziwei Zhang, Zhilei Qian, Rui Ma, Minna Luan, Yu Sun.  (2024)  Sequentially Released Liposomes Enhance Anti-Liver Cancer Efficacy of Tetrandrine and Celastrol-Loaded Coix Seed Oil.  International Journal of Nanomedicine,      [PMID:38288265] [10.2147/IJN.S446895]

12. Qing Wang, Jie Chen, Kun Huang, Xin Zhang, Li Xu, Zhi-guo Shi.  (2014)  Preparation, characterization and application of N-methylene phosphonic acid chitosan grafted magnesia–zirconia stationary phase.  ANALYTICA CHIMICA ACTA,      [PMID:25479884] [10.1016/j.aca.2014.11.022]

13. Liyun Ma, Si-Min Liu, Lin Yao, Li Xu.  (2014)  Preparation and chromatographic performance evaluation of cucurbit[7]uril immobilized silica.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:25528071] [10.1016/j.chroma.2014.12.002]

14. Xinyan Chen, Xiao Yu, Hao Feng, Panpan Shang, Muhammad Shafiq, Zhengchao Yuan, Cheng Li, Zewen Wang, Zhenchao Liu, Yuan Yao, Mohamed EL-Newehy, Meera Moydeen Abdulhameed, Yan Xiong, Yuan Xu, Xiumei Mo.  (2025)  Tetrandrine-loaded electrospun scaffold modulates inflammation and fibroblast activity to promote tendon regeneration.  Applied Materials Today,      [PMID:] [10.1016/j.apmt.2025.102723]

15. Yifan Peng, Xiaoqin Cai, Shanshan Wang, Kaikun Pi, Bin Sun, Yan Li, Bing Liu, Fangxiang Song.  (2025)  Anisotropic Growth Method for Constructing Stimulus-Responsive Janus Composite Nanoparticles for Dual-Drug Delivery in Tumor Therapy.  COLLOIDS AND SURFACES B-BIOINTERFACES,      [PMID:41317457] [10.1016/j.colsurfb.2025.115301]

16. Yue Zhang, Xi Liu, Li Hu, Tengyun Zuo, Kun Xia, Hao Wang, Huaming Yang.  (2026)  Inorganic–Organic Interfacial Engineering of Earth-Abundant Phytoliths for Multifunctional Hemostat.  ACS Applied Bio Materials,      [PMID:41563372] [10.1021/acsabm.5c02277]

17. Huanhuan Zhu, Yong Xu, Jiafen Huang, Yiheng Zhang, Manman Sun, Zhiming Wang, Yurong Wang.  (2026)  Multimodal Voltammetric sensor using Pd@ErGO nanocomposite for selective or simultaneous determination of Tetrandrine and Fangchinoline in traditional Chinese medicine and biological matrices.  Results in Chemistry,      [PMID:] [10.1016/j.rechem.2026.103274]