Fluoruro de talidomida - ≥98% , CAS No.835616-60-9

CAS: 835616-60-9 Cat. No.: T304742 Peso molecular: 276.22 Número EC: 830-714-5 PubChem CID: 11859051

GRADE & PURITY ≥98%

Synonyms

E3 ligase Ligand 4 | E3 ligase Ligand 4(TC-E3 5032) | MFCD11840666 | FT-0774298 | LCZC1115 | US11059801, Compound D-14 | 4-Fluoro-thalidomide | MS-0703 | TC E3 5032;2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione | Thalidomide fluoride | 2-(2,6-

Storage

Protegido de la luz,Almacenar a -20°C,Cargado con argón

Shipped In

Hielera + almohadillas de hielo

Descripción general

la 2-(2,6-Dioxo-3-piperidinil)-4-fluoro-1H-isoindol-1,3(2H)-diona es un intermediario en la síntesis de la sal N-[2-Aminoetil] Pomalidomida TFA (N-[2-Aminoetil] Pomalidomida TFA es un derivado de la talidomida, un potente inhibidor de la producción de TNF-α. Es un agente antiinflamatorio y antitumoral utilizado en el tratamiento del mieloma múltiple.

Specifications

Sinónimos

E3 ligase Ligand 4 | E3 ligase Ligand 4(TC-E3 5032) | MFCD11840666 | FT-0774298 | LCZC1115 | US11059801, Compound D-14 | 4-Fluoro-thalidomide | MS-0703 | TC E3 5032;2-(2, 6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1, 3-dione | Thalidomide fluoride | 2-(2, 6-

Especificaciones y pureza

≥98%

Condiciones de almacenamiento de almacenamiento

Protegido de la luz, Almacenar a -20°C, Cargado con argón

Enviado en

Hielera + almohadillas de hielo

Pureza

≥98%

Nombres e identificadores

• Pubchem Sid: 504766792
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504766792
• Sonrisas canónicas: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)F
• IUPAC Name: 2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindole-1,3-dione
• InChIKey: CRAUTELYXAAAPW-UHFFFAOYSA-N
• INCHI: 1S/C13H9FN2O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5H2,(H,15,17,18)
• Isómeros SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)F
• PubChem CID: 11859051
• Peso molecular: 276.22

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Isoindoles and derivatives
      • Subclass Isoindolines
        • Level5 Isoindolones
          • Level6 Phthalimides

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Isoindoles and derivatives
• Subclass: Isoindolines
• Intermediate Tree Nodes: Isoindolones
• Direct Parent: Phthalimides
• Alternative Parents: Alpha amino acids and derivatives Isoindoles Piperidinediones Delta lactams Aryl fluorides N-substituted carboxylic acid imides Benzenoids Vinylogous halides N-unsubstituted carboxylic acid imides Dicarboximides Azacyclic compounds Carbonyl compounds Hydrocarbon derivatives Organic oxides Organofluorides Organonitrogen compounds
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Phthalimide - Alpha-amino acid or derivatives - Isoindole - Piperidinedione - Delta-lactam - Piperidinone - Aryl fluoride - Aryl halide - Carboxylic acid imide, n-substituted - Benzenoid - Piperidine - Carboxylic acid imide - Dicarboximide - Vinylogous halide - Carboxylic acid imide, n-unsubstituted - Lactam - Azacycle - Carboxylic acid derivative - Organic oxide - Organic oxygen compound - Hydrocarbon derivative - Organic nitrogen compound - Carbonyl group - Organohalogen compound - Organofluoride - Organonitrogen compound - Organooxygen compound - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as phthalimides. These are aromatic heterocyclic compounds containing a 1,3-dioxoisoindoline moiety. They are imide derivatives of phthalic anhydrides.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propiedades químicas y físicas

• Solubilidad: Dichloromethane (Slightly, Heated), DMSO (Slightly)
• Sensibilidad: Light & Heat & Air sensitive
• Punto de ebullición (°C): 520.9±45.0 °C(Predicted)
• Punto de fusión (°C): 254-256℃
• Peso molecular: 276.220 g/mol
• XLogP3: 0.400
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 276.055 Da
• Monoisotopic Mass: 276.055 Da
• Topological Polar Surface Area: 83.600 Ų
• Heavy Atom Count: 20
• Formal Charge: 0
• Complexity: 507.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referencias

1. SiJia Lin, Lin Wang, Xue Dong, ZiYi Wang, Jin Cao, Xueyong Qi, Lin Wu, Jing Zhang, Song Shen.  (2025)  Precision Ferroptosis Amplification via SLC7A11-Directed Proteasomal Degradation for Enhanced Cancer Therapy.  Advanced Healthcare Materials,      [PMID:41467569] [10.1002/adhm.202504602]

2. ZiYi Wang, SiJia Lin, Xue Dong, Jin Cao, Rong Zhao, Lin Wu, Song Shen.  (2026)  Targeted Degradation of Dipeptidyl Peptidase-4 via Proteolysis-Targeting Chimera Technology for Sustained Glycemic Control in Type 2 Diabetes.  JOURNAL OF MEDICINAL CHEMISTRY,      [PMID:] [10.1021/acs.jmedchem.5c03270]