THZ1 Hydrochloride - 10mM in DMSO , CAS No.T661619(DMSO)

CAS: T661619(DMSO) Cat. No.: T661619 Peso molecular: 602.51

GRADE & PURITY 10mM in DMSO

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

THZ1 Hydrochloride is a selective and potent covalent CDK7 inhibitor with an IC 50 of 3.2 nM. THZ1 Hydrochloride also inhibits the closely related kinases CDK12 and CDK13 and downregulates MYC expression.

IC50& Target:CDK7|3.2 nM (IC|50|)|CDK12|CDK13

In Vitro:THZ1 inhibits Jurkat cell and Loucy cell with IC 50 of 50 nM, and 0.55 nM, respectively. THZ1 demonstrates time-dependent inhibition of CDK7 in vitro and covalent binding of intracellular CDK7. THZ1 (9, 27, 83, 250, 750, and 2500 nM) inhibits CDK12 but at

In Vivo:THZ1 (10mg/kg) demonstrates potent killing of primary chronic lymphocytic leukemia (CLL) cells and anti-proliferative activity against primary TALL cells and in vivo against a human T-ALL xenograft. THZ1 (10mg/kg, i.v.) inhibits tumor growth in a m

Biological Activity:THZ1 Hydrochloride is a selective and potent covalent CDK7 inhibitor with an IC 50 of 3.2 nM. THZ1 Hydrochloride also inhibits the closely related kinases CDK12 and CDK13 and downregulates MYC expression .

Specifications

Especificaciones y pureza

10mM in DMSO

Condiciones de almacenamiento de almacenamiento

Desiccated, Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Nombres e identificadores

• Sonrisas canónicas: ClC1=CN=C(NC2=CC(NC(C3=CC=C(NC(/C=C/CN(C)C)=O)C=C3)=O)=CC=C2)N=C1C4=CNC5=CC=CC=C54.Cl
• Peso molecular: 602.51