(-)-TK216 - Moligand™,10mM in DMSO , CAS No.1903783-78-7

CAS: 1903783-78-7 Cat. No.: T655209 Fórmula: C₁₉H₁₅Cl₂NO₃ Peso molecular: 376.23 PubChem CID: 121268274

CALIDAD & PUREZA Moligand™, 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

(-)-TK216 is an enantiomer of TK216 . TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor. (-)-TK216 has anti-cancer activity.

In Vitro

(-)-TK216 (compound 14; for 3 days) has an IC 50 <5 μM in SKES cells (Ewing Sarcoma cell line). (-)-TK216 has T 1/2 s of 27.7 mins, 2.8 mins, 23.1 mins and 40.8 mins for human, rat, mouse, dog liver microsomes. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

(-)-TK216 (compound 14; 5 mg/kg for iv or 25 mg/kg for po) has T 1/2 s of 0.8 hours and 3.1 hours, and AUCs of 4131 h•(ng/mL) and 13152 h•(ng/mL) for iv and po, respectively, in BALB/c mice or Sprague Dawley rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Especificaciones

Especificaciones y pureza

Moligand™,10mM in DMSO

Mecanismos bioquímicos y fisiológicos

(-)-TK216 is an enantiomer of TK216 ( HY-122903 ). TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor. (-)-TK216 has anti-cancer activity.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Grado

Moligand™

Tipo de acción

INHIBITOR

Nombres e identificadores

PubChem CID

121268274

Peso molecular

376.23