TMPyP [=α,β,γ,δ-Tetrakis(1-methylpyridinium-4-yl)porphyrin p-Toluenesulfonate] - 10mM in Water , CAS No.36951-72-1

CAS: 36951-72-1 Cat. No.: T423657 Peso molecular: 1363.6 Número EC: 636-829-5

GRADE & PURITY 10mM in Water

Synonyms

TMPyP;5,10,15,20-Tetrakis(1-methyl-4-pyridinio)porphyrin tetra(p-toluenesulfonate);α,β,γ,δ-Tetrakis(1-methylpyridinium-4-yl)porphyrin p-Toluenesulfonate

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

TMPyP [=α,β,γ,δ-Tetrakis(1-methylpyridinium-4-yl)porphyrin p-Toluenesulfonate] (TMPyP) is a positively charged, two-photon dye, that can bind to DNA in cell cultures and affect the cell viability. Long term encapsulation of TMPyP by nanoparticles is reported to prevent the dye from direct contact with cells, but the dye can still kill the cells via singlet-oxygen production on exposure to infrared light. Nanostructured catalyst of platinum nanoparticles supported on TMPyP functionalized graphene is prepared by hydrothermal polyol process. TMPyP is reported to show excellent 1O2 luminescence signals on incubation with the fungus, Candida albicans. On photoexcitation, TMPyP undergoes charge-transfer interaction with chemically reduced graphene oxide. It is also reported to be a promising photodynamic therapy photosensitizer.

TMPyP [=α,β,γ,δ-Tetrakis(1-methylpyridinium-4-yl)porphyrin p-Toluenesulfonate] (TMPyP), a cationic porphyrin, was used to study the noncovalent functionalization of graphene with cationic porphyrins using UV-vis and fluorescence methods. TMPyP may be used as an optical indicator ligand in the preparation of multifunctional membrane for visual warning and enhanced adsorptive removal of cadmium ions in aqueous solutions. TMPyP was also used to fabricate the (TMPyP)- single-walled carbon nanotubes (SWNT)/sodium copper chlorophyllin-SWNT layer-by-layer film from noncovalently adsorbed composites.

Specifications

Sinónimos

TMPyP;5, 10, 15, 20-Tetrakis(1-methyl-4-pyridinio)porphyrin tetra(p-toluenesulfonate);α, β, γ, δ-Tetrakis(1-methylpyridinium-4-yl)porphyrin p-Toluenesulfonate

Especificaciones y pureza

10mM in Water

Mecanismos bioquímicos y fisiológicos

Cationic porphyrin. Telomerase inhibitor (IC 50 = 6.5 µM). Binds and stabilizes DNA G quadruplexes resulting in telomerase inhibition. Displays antitumor effect.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Nombres e identificadores

• Peso molecular: 1363.6
• Reaxy-Rn: 5237096

Propiedades químicas y físicas

• Sensibilidad: Light & Moisture Sensitive

Referencias

1. Decheng Lu, Xiaoqian Zhou, Lixing Lin, Xinying Zhang, Yingying Chen, Lingyan Feng.  (2024)  Porphyrin-functionalized glutathione-Ti3C2 MXene quantum dots for enhanced electrochemiluminescence and sensitive detection of copper ions.  JOURNAL OF ELECTROANALYTICAL CHEMISTRY,      [PMID:] [10.1016/j.jelechem.2024.118285]

2. Xiaohui Chen, Haixia Liu, Ningyu Ma, Chenyu Sun, Yican Li, Hengyi Chen, Qianqian Wu, Zhizeng Wang, Jichun Yang, Guoxiang Liu, Yang Luo.  (2025)  Precise Determination of CpG Methylation through Entropy-Driven Cascade Circuit.  ANALYTICAL CHEMISTRY,      [PMID:40478770] [10.1021/acs.analchem.5c01453]