Antígeno Tn - ≥99%(TLC) , CAS No.67262-86-6

CAS: 67262-86-6 Cat. No.: T755077 Fórmula: C₁₁H₂₀N₂O₈ Peso molecular: 308.29

GRADE & PURITY ≥99%(TLC)

Storage

Conservar a -20°C

Shipped In

Hielera + almohadillas de hielo

Descripción general

El antígeno Tn es un O-glicano truncado que suele observarse en el cáncer colorrectal (CCR). Suele expresarse en altos niveles en las células cancerosas. El antígeno Tn es de tamaño pequeño y estructura simple. Tiene una estructura de glicano no fisiológica en humanos, por lo que puede ser identificado como extraño por el sistema inmunitario.

Specifications

Especificaciones y pureza

≥99%(TLC)

Mecanismos bioquímicos y fisiológicos

El antígeno Tn estimula la metástasis del cáncer colorrectal mediante la activación de la transición epitelio-mesénquima, mediada por H-Ras. Actúa como precursor de varios O-glicanos complejos significativos. Las subpoblaciones de células sanguíneas de to

Condiciones de almacenamiento de almacenamiento

Conservar a -20°C

Enviado en

Hielera + almohadillas de hielo

Pureza

≥99%(TLC)

Nombres e identificadores

Sonrisas canónicas

CC(=O)NC1C(C(C(OC1OCC(C(=O)O)N)CO)O)O

IUPAC Name

(2S)-3-[(2S,3R,4R,5R,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-aminopropanoic acid

InChIKey

REDMNGDGDYFZRE-WKWISIMFSA-N

INCHI

1S/C11H20N2O8/c1-4(15)13-7-9(17)8(16)6(2-14)21-11(7)20-3-5(12)10(18)19/h5-9,11,14,16-17H,2-3,12H2,1H3,(H,13,15)(H,18,19)/t5-,6+,7+,8-,9+,11-/m0/s1

Isómeros SMILES

CC(=O)N[C@@H]1[C@H]([C@H]([C@H](O[C@@H]1OC[C@@H](C(=O)O)N)CO)O)O

Peso molecular

308.29

Reaxy-Rn

53463527

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=53463527&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Clase Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Glycosyl-amino acids

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Clase: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives
• Direct Parent: Glycosyl-amino acids
• Alternative Parents: Fatty acyl glycosides of mono- and disaccharides N-acyl-alpha-hexosamines Hexoses O-glycosyl compounds L-alpha-amino acids Sugar acids and derivatives Oxanes Acetamides Secondary carboxylic acid amides Secondary alcohols Amino acids Acetals Oxacyclic compounds Carboxylic acids Monocarboxylic acids and derivatives Organopnictogen compounds Primary alcohols Organic oxides Hydrocarbon derivatives Carbonyl compounds Monoalkylamines
• Molecular Framework: Aliphatic heteromonocyclic compounds
• Substituents: Glycosyl-amino-acid - Fatty acyl glycoside - Fatty acyl glycoside of mono- or disaccharide - N-acyl-alpha-hexosamine - Hexose monosaccharide - Glycosyl compound - O-glycosyl compound - Alpha-amino acid - Alpha-amino acid or derivatives - L-alpha-amino acid - Sugar acid - Monosaccharide - Fatty acyl - Oxane - Acetamide - Secondary carboxylic acid amide - Secondary alcohol - Carboxamide group - Amino acid - Organoheterocyclic compound - Carboxylic acid - Acetal - Monocarboxylic acid or derivatives - Oxacycle - Primary amine - Primary aliphatic amine - Hydrocarbon derivative - Alcohol - Organic oxide - Organopnictogen compound - Organonitrogen compound - Organooxygen compound - Carbonyl group - Amine - Organic oxygen compound - Organic nitrogen compound - Primary alcohol - Aliphatic heteromonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as glycosyl-amino acids. These are compounds consisting of saccharide linked through a glycosyl linkage (O-, N-, or S-) to an amino acid.
• External Descriptors: non-proteinogenic L-alpha-amino acid - L-serine derivative

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propiedades químicas y físicas

• Peso molecular: 308.290 g/mol
• XLogP3: -5.600
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 6
• Exact Mass: 308.122 Da
• Monoisotopic Mass: 308.122 Da
• Topological Polar Surface Area: 172.000 Ų
• Heavy Atom Count: 21
• Formal Charge: 0
• Complexity: 379.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 6
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Preguntas frecuentes

What is the purity of this product, and how is it determined?

This product is supplied at ≥99% purity, determined by TLC. Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 67262-86-6, the molecular formula is C11H20N2O8, and the molecular weight is 308.29 g/mol. InChIKey REDMNGDGDYFZRE-WKWISIMFSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.