Antígeno Tn - ≥99%(TLC) , CAS No.67262-86-6

CAS: 67262-86-6 Cat. No.: T755077 Peso molecular: 308.29

GRADE & PURITY ≥99%(TLC)

Storage

Conservar a -20°C

Shipped In

Hielera + almohadillas de hielo

Descripción general

El antígeno Tn es un O-glicano truncado que suele observarse en el cáncer colorrectal (CCR). Suele expresarse en altos niveles en las células cancerosas. El antígeno Tn es de tamaño pequeño y estructura simple. Tiene una estructura de glicano no fisiológica en humanos, por lo que puede ser identificado como extraño por el sistema inmunitario.

Specifications

Especificaciones y pureza

≥99%(TLC)

Mecanismos bioquímicos y fisiológicos

El antígeno Tn estimula la metástasis del cáncer colorrectal mediante la activación de la transición epitelio-mesénquima, mediada por H-Ras. Actúa como precursor de varios O-glicanos complejos significativos. Las subpoblaciones de células sanguíneas de to

Condiciones de almacenamiento de almacenamiento

Conservar a -20°C

Enviado en

Hielera + almohadillas de hielo

Pureza

≥99%(TLC)

Nombres e identificadores

• Sonrisas canónicas: CC(=O)NC1C(C(C(OC1OCC(C(=O)O)N)CO)O)O
• IUPAC Name: (2S)-3-[(2S,3R,4R,5R,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-aminopropanoic acid
• InChIKey: REDMNGDGDYFZRE-WKWISIMFSA-N
• INCHI: 1S/C11H20N2O8/c1-4(15)13-7-9(17)8(16)6(2-14)21-11(7)20-3-5(12)10(18)19/h5-9,11,14,16-17H,2-3,12H2,1H3,(H,13,15)(H,18,19)/t5-,6+,7+,8-,9+,11-/m0/s1
• Isómeros SMILES: CC(=O)N[C@@H]1[C@H]([C@H]([C@H](O[C@@H]1OC[C@@H](C(=O)O)N)CO)O)O
• Peso molecular: 308.29
• Reaxy-Rn: 53463527
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=53463527&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Clase Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Glycosyl-amino acids

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Clase: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives
• Direct Parent: Glycosyl-amino acids
• Alternative Parents: Fatty acyl glycosides of mono- and disaccharides N-acyl-alpha-hexosamines Hexoses O-glycosyl compounds L-alpha-amino acids Sugar acids and derivatives Oxanes Acetamides Secondary carboxylic acid amides Secondary alcohols Amino acids Acetals Oxacyclic compounds Carboxylic acids Monocarboxylic acids and derivatives Organopnictogen compounds Primary alcohols Organic oxides Hydrocarbon derivatives Carbonyl compounds Monoalkylamines
• Molecular Framework: Aliphatic heteromonocyclic compounds
• Substituents: Glycosyl-amino-acid - Fatty acyl glycoside - Fatty acyl glycoside of mono- or disaccharide - N-acyl-alpha-hexosamine - Hexose monosaccharide - Glycosyl compound - O-glycosyl compound - Alpha-amino acid - Alpha-amino acid or derivatives - L-alpha-amino acid - Sugar acid - Monosaccharide - Fatty acyl - Oxane - Acetamide - Secondary carboxylic acid amide - Secondary alcohol - Carboxamide group - Amino acid - Organoheterocyclic compound - Carboxylic acid - Acetal - Monocarboxylic acid or derivatives - Oxacycle - Primary amine - Primary aliphatic amine - Hydrocarbon derivative - Alcohol - Organic oxide - Organopnictogen compound - Organonitrogen compound - Organooxygen compound - Carbonyl group - Amine - Organic oxygen compound - Organic nitrogen compound - Primary alcohol - Aliphatic heteromonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as glycosyl-amino acids. These are compounds consisting of saccharide linked through a glycosyl linkage (O-, N-, or S-) to an amino acid.
• External Descriptors: non-proteinogenic L-alpha-amino acid - L-serine derivative

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propiedades químicas y físicas

• Peso molecular: 308.290 g/mol
• XLogP3: -5.600
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 6
• Exact Mass: 308.122 Da
• Monoisotopic Mass: 308.122 Da
• Topological Polar Surface Area: 172.000 Ų
• Heavy Atom Count: 21
• Formal Charge: 0
• Complexity: 379.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 6
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1