TNF-α Inhibitor - ≥95% , CAS No.1049741-03-8

CAS: 1049741-03-8 Cat. No.: T336348 Peso molecular: 629.6 Número EC: 690-589-6 PubChem CID: 73234871

GRADE & PURITY ≥95%

Synonyms

6,7-Dimethyl-3-((methyl-(2-(methyl-(1-(3-trifluoromethyl-phenyl)-1H-indol-3-ylmethyl)-amino)-ethyl)-amino)-methyl)-chromen-4-one, diHCl

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

TNF-α Inhibitor is a cell-permeable indolyl-chromenone compound reported to rapidly inactivate TNF-α via non-covalently binding to the TNF-α trimer, promoting subunit dissociation and preventing TNF-α binding to its receptor. Additionally reported to selectively inhibit TNF-α-, but not IL-1β-induced Iκβ-α degradation in HeLa cells.

Specifications

Sinónimos

6, 7-Dimethyl-3-((methyl-(2-(methyl-(1-(3-trifluoromethyl-phenyl)-1H-indol-3-ylmethyl)-amino)-ethyl)-amino)-methyl)-chromen-4-one, diHCl

Especificaciones y pureza

≥95%

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Pureza

≥95%

Nombres e identificadores

• Sonrisas canónicas: CC1CC2C(CC1C)OC=C(C2=O)CN(C)CCN(C)CC3=CN(C4=CC=CC=C43)C5=CC=CC(=C5)C(F)(F)F.Cl.Cl
• IUPAC Name: 6,7-dimethyl-3-[[methyl-[2-[methyl-[[1-[3-(trifluoromethyl)phenyl]indol-3-yl]methyl]amino]ethyl]amino]methyl]-4a,5,6,7,8,8a-hexahydrochromen-4-one;dihydrochloride
• InChIKey: VGTHKUOPIXHQPK-UHFFFAOYSA-N
• INCHI: 1S/C32H38F3N3O2.2ClH/c1-21-14-28-30(15-22(21)2)40-20-24(31(28)39)18-37(4)13-12-36(3)17-23-19-38(29-11-6-5-10-27(23)29)26-9-7-8-25(16-26)32(33,34)35;;/h5-11,16,19-22,28,30H,12-15,17-18H2,1-4H3;2*1H
• Isómeros SMILES: CC1CC2C(CC1C)OC=C(C2=O)CN(C)CCN(C)CC3=CN(C4=CC=CC=C43)C5=CC=CC(=C5)C(F)(F)F.Cl.Cl
• PubChem CID: 73234871
• Peso molecular: 629.6

Propiedades químicas y físicas

• Solubilidad: Soluble in DMSO (10 mg/ml).
• Índice de refracción: n20D~1.58 (Predicted)