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Why this grade
Moligand™, ≥99% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Descripción general
TP-10 is a selective PDE10A inhibitor with an IC 50 value of 0.8 nM. TP-10 shows an antioxidant activity with IC 50 s of 31.72 and 16.04 μg/ml for DPPH and CUPRAC, respectively. TP-10 can be used for the research of neuropathy
In Vitro（for reference only）
TP-10 (10 μg /mL; 24 h) affects total reactive oxygen species in human brain-derived cells (U-87 MG).
Cell Viability Assay
Cell Line: U-87 MG cells
Concentration: 10 μg/ml
Incubation Time: 24 hours
Result: Decreased the total number of ROS-positive cells and showed no toxic effects to U-87 MG cells.
In Vivo（for reference only）
TP-10 (0.1-10 mg/kg; i.h. once) shows an effect on cyclic nucleotides.
Animal Model: Male CD rats
Dosage: 0.1, 0.32, 1.0, 3.2 and 10 mg/kg
Administration: Subcutaneous injection; 0.1-10 mg/kg once
Result: Dose- and time-dependently increased the levels of both cGMP and cAMP in striatal of mice. Increased pCREB-LI level first and returned to basal levels after injected for 3 hours at a dose of 3.2 mg/kg.
Form:Solid
IC50& Target:IC50: 0.8 nM (PDE10A), 31.72 μg/mL (DPPH), 16.04 μg/mL (CUPRAC)
Specifications
Especificaciones y pureza
Moligand™, ≥99%
Mecanismos bioquímicos y fisiológicos
TP-10 is a selective PDE10A inhibitor with an IC 50 value of 0.8 nM. TP-10 shows an antioxidant activity with IC 50 s of 31.72 and 16.04 μg/ml for DPPH and CUPRAC, respectively. TP-10 can be used for the research of neuropathy.
Condiciones de almacenamiento de almacenamiento
Store at -20°C
Enviado en
Ice chest + Ice pads
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Grado
Moligand™
Tipo de acción
INHIBITOR
Pureza
≥99%
Nombres e identificadores
| Peso molecular | 460.45 |
|---|
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Propiedades químicas y físicas
| Solubilidad | DMSO : 100 mg/mL (217.18 mM; Need ultrasonic) |
|---|
Calculadoras de soluciones
Reseñas
Reseñas de cliente
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View Moligand™ grade guide →Artículos relacionados
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