TPCK - Moligand™, 10 mM in DMSO , CAS No.402-71-1

CAS: 402-71-1 Cat. No.: T1495595 Peso molecular: 351.85 Beilstein Registry Number: 2895215 Número EC: 206-954-6

GRADE & PURITY Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

TPCK (L-1-Tosylamido-2-phenylethyl chloromethyl ketone; L-TPCK) is an effective serine protease inhibitor and also a blocker of the PDK1/Akt pathway. TPCK can modify the E7 protein in actively keratinocyte cells. TPCK can induce cellular apoptosis , suppress tumor growth, reduce hypoxic-ischemic brain injury in rat pups, and affect vascular permeability in inflamed rats.

Specifications

Especificaciones y pureza

Moligand™, 10 mM in DMSO

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Nombres e identificadores

• Isómeros SMILES: CC1=CC=C(C=C1)S(=O)(=O)N[C@@H](CC2=CC=CC=C2)C(=O)CCl
• RTECS: XT5613500
• Peso molecular: 351.85
• Beilstein: 2895215
• Reaxy-Rn: 2895215
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2895215&ln=

Propiedades químicas y físicas

• Rotación específica [α]: -87.0 to -91.0 deg(C=1, EtOH)
• Punto de fusión (°C): 106.0 to 110.0 °C

Referencias

1. Yi-ni Lu, Xiao-han Wang, Bo-cheng Xu, Yufen Zheng, Xiong Zhang, Yi Liu, Tian-yin Wang, Feng Yu.  (2025)  Urinary Trypsin Inhibitor Exerts Multifaceted Regulation of Angiopoietin 2 in Septic Cardiomyopathy.  EUROPEAN JOURNAL OF PHARMACOLOGY,      [PMID:40651788] [10.1016/j.ejphar.2025.177944]