trans-10-Hydroxy-2-decenoic Acid - ≥97%(T) , CAS No.14113-05-4

CAS: 14113-05-4 Cat. No.: H140068 Peso molecular: 186.25 Número EC: 808-119-7

GRADE & PURITY ≥97%(T)

Synonyms

(2E)-10-hydroxydec-2-enoic acid | Q16908844 | QHBZHVUGQROELI-SOFGYWHQSA-N | Silotermo Carmine G | trans-10-hydroxydec-2-enoic acid | DS-18448 | 10-Hydroxy-2-decylenic acid | (E)-10-Hydroxy-2-decenoic acid | AC-34577 | DTXSID601045504 | LMFA01050157 | Quee

Storage

Store at 2-8°C

Shipped In

Wet ice

Specifications

Sinónimos

(2E)-10-hydroxydec-2-enoic acid | Q16908844 | QHBZHVUGQROELI-SOFGYWHQSA-N | Silotermo Carmine G | trans-10-hydroxydec-2-enoic acid | DS-18448 | 10-Hydroxy-2-decylenic acid | (E)-10-Hydroxy-2-decenoic acid | AC-34577 | DTXSID601045504 | LMFA01050157 | Quee

Especificaciones y pureza

≥97%(T)

Mecanismos bioquímicos y fisiológicos

VEGF inhibitor. Inhibits VEGF-induced angiogenesis. Suppresses VEGF-induced endothelial cell proliferation and migration. Promotes neurogenesis. Shows antiangiogenic, antioxidant and DNA-protective effects in vivo. Orally active.

Condiciones de almacenamiento de almacenamiento

Store at 2-8°C

Enviado en

Wet ice

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Nota

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Pureza

≥97%(T)

Nombres e identificadores

• Pubchem Sid: 504763565
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504763565
• Sonrisas canónicas: C(CCCC=CC(=O)O)CCCO
• IUPAC Name: (E)-10-hydroxydec-2-enoic acid
• InChIKey: QHBZHVUGQROELI-SOFGYWHQSA-N
• INCHI: 1S/C10H18O3/c11-9-7-5-3-1-2-4-6-8-10(12)13/h6,8,11H,1-5,7,9H2,(H,12,13)/b8-6+
• Isómeros SMILES: C(CCC/C=C/C(=O)O)CCCO
• Peso molecular: 186.25
• Reaxy-Rn: 1765264
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1765264&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Clase Hydroxy acids and derivatives
      • Subclass Medium-chain hydroxy acids and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Clase: Hydroxy acids and derivatives
• Subclass: Medium-chain hydroxy acids and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Medium-chain hydroxy acids and derivatives
• Alternative Parents: Medium-chain fatty acids Hydroxy fatty acids Unsaturated fatty acids Straight chain fatty acids Monocarboxylic acids and derivatives Carboxylic acids Primary alcohols Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Medium-chain hydroxy acid - Medium-chain fatty acid - Hydroxy fatty acid - Straight chain fatty acid - Fatty acyl - Fatty acid - Unsaturated fatty acid - Carboxylic acid derivative - Carboxylic acid - Monocarboxylic acid or derivatives - Carbonyl group - Organic oxide - Organic oxygen compound - Alcohol - Organooxygen compound - Primary alcohol - Hydrocarbon derivative - Aliphatic acyclic compound
• Descripción: This compound belongs to the class of organic compounds known as medium-chain hydroxy acids and derivatives. These are hydroxy acids with a 6 to 12 carbon atoms long side chain.
• External Descriptors: Hydroxy fatty acids

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propiedades químicas y físicas

• Sensibilidad: Heat sensitive
• Punto de fusión (°C): 64.0-68.0℃
• Peso molecular: 186.250 g/mol
• XLogP3: 2.200
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 8
• Exact Mass: 186.126 Da
• Monoisotopic Mass: 186.126 Da
• Topological Polar Surface Area: 57.500 Ų
• Heavy Atom Count: 13
• Formal Charge: 0
• Complexity: 152.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 1
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 1
• Covalently-Bonded Unit Count: 1

Referencias

1. Shixuan Su, Shanshan Li, Jing Hu, Ting Yu, Lingchen Tao, Fuliang Hu, Yunlei Xianyu.  (2021)  A colorimetric sensing strategy for detecting 10-hydroxy-2-decenoic acid in royal jelly based on Ag(I)-tetramethylbenzidine.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2021.131241]

2. Shuai Zhuang, Huihui Ming, Wenjie Yu, Liping Luo.  (2024)  Identification of freshness and metabolite changes of royal jelly during storage using Nano-ESI-MS and UPLC-Q/TOF-MS.  JOURNAL OF FOOD COMPOSITION AND ANALYSIS,      [PMID:] [10.1016/j.jfca.2024.107092]

3. Xinqi Huang, Lu Xiu, Yumei An, Yuan Gong, Sunao Li, Xueshi Chen, Chao Liu, Jianghuiwen Lu, Haiyan Shan, Jie Chang, Mingyang Zhang.  (2024)  Preventive Effect of Royal Jelly and 10-HDA on Skin Damage in Diabetic Mice through Regulating Keratinocyte Wnt/β-Catenin and Pyroptosis Pathway.  MOLECULAR NUTRITION & FOOD RESEARCH,  68  (19): (2400098).  [PMID:39246232] [10.1002/mnfr.202400098]