Triethyl citrate(TEC) - ≥98% , CAS No.77-93-0

CAS: 77-93-0 Cat. No.: T106153 Peso molecular: 276.28 Beilstein Registry Number: 1801199 Número EC: 201-070-7 PubChem CID: 6506

GRADE & PURITY ≥98%

Synonyms

TRIETHYL CITRATE | TRIETHYL CITRATE [USP-RS] | Triaethylcitrat [German] | Triethyl citrate, Vetec(TM) reagent grade, 98% | Citroflex 2 | TRIETHYL CITRATE [FCC] | SR-01000883952-1 | Triethyl citrate, United States Pharmacopeia (USP) Reference Standard | TR

Storage

Room temperature,Desiccated,Cool

Shipped In

Normal

Descripción general

Triethyl citrate was used as a plasticizer in the study of the feasibility of near-infrared (NIR) spectroscopy in determining the influence of plasticizer levels and sintering temperature on the breaking force of extended-release matrix tablets prepared by roller-compaction

Specifications

Sinónimos

TRIETHYL CITRATE | TRIETHYL CITRATE [USP-RS] | Triaethylcitrat [German] | Triethyl citrate, Vetec(TM) reagent grade, 98% | Citroflex 2 | TRIETHYL CITRATE [FCC] | SR-01000883952-1 | Triethyl citrate, United States Pharmacopeia (USP) Reference Standard | TR

Especificaciones y pureza

≥98%

Condiciones de almacenamiento de almacenamiento

Room temperature, Desiccated, Cool

Enviado en

Normal

Pureza

≥98%

Nombres e identificadores

• Pubchem Sid: 504751106
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504751106
• Sonrisas canónicas: CCOC(=O)CC(CC(=O)OCC)(C(=O)OCC)O
• IUPAC Name: triethyl 2-hydroxypropane-1,2,3-tricarboxylate
• InChIKey: DOOTYTYQINUNNV-UHFFFAOYSA-N
• INCHI: 1S/C12H20O7/c1-4-17-9(13)7-12(16,11(15)19-6-3)8-10(14)18-5-2/h16H,4-8H2,1-3H3
• Isómeros SMILES: CCOC(=O)CC(CC(=O)OCC)(C(=O)OCC)O
• WGK Alemania: 1
• RTECS: GE8050000
• PubChem CID: 6506
• Peso molecular: 276.28
• Beilstein: 1801199
• Reaxy-Rn: 1801199

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Clase Carboxylic acids and derivatives
      • Subclass Tricarboxylic acids and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Clase: Carboxylic acids and derivatives
• Subclass: Tricarboxylic acids and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Tricarboxylic acids and derivatives
• Alternative Parents: Fatty acid esters Tertiary alcohols Carboxylic acid esters Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Tricarboxylic acid or derivatives - Fatty acid ester - Fatty acyl - Tertiary alcohol - Carboxylic acid ester - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Carbonyl group - Alcohol - Aliphatic acyclic compound
• Descripción: This compound belongs to the class of organic compounds known as tricarboxylic acids and derivatives. These are carboxylic acids containing exactly three carboxyl groups.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (no humanos)

Mus musculus (284745 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: Miscible with water, alcohol and diethyl ether.
• Índice de refracción: 1.44-1.443
• Punto de inflamación (°F): 311 °F
• Punto de inflamación (°C): 155℃
• Punto de ebullición (°C): 235°C
• Punto de fusión (°C): -46°C
• Peso molecular: 276.280 g/mol
• XLogP3: 0.100
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 11
• Exact Mass: 276.121 Da
• Monoisotopic Mass: 276.121 Da
• Topological Polar Surface Area: 99.100 Ų
• Heavy Atom Count: 19
• Formal Charge: 0
• Complexity: 304.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referencias

1. Yanqin Shi, Lukai Chen, Songyan Lu, Yuchen Yao, Si Chen, Huiwen He, Meng Ma, Xu Wang.  (2023)  A new organic zinc thermal stabilizer containing two kinds of anions with excellent thermal stability on polyvinyl chloride by multistep substitution.  JOURNAL OF APPLIED POLYMER SCIENCE,  140  (24): (e53960).  [PMID:] [10.1002/app.53960]

2. Xiaomeng Tang, Meng Yang, Yongwei Gu, Liangdi Jiang, Yue Du, Jiyong Liu.  (2022)  Orally Deliverable Dual-Targeted Pellets for the Synergistic Treatment of Ulcerative Colitis.  Drug Design Development and Therapy,      [PMID:34616144] [10.2147/DDDT.S322702]

3. Zhang Weibin, Zhu Chunhua, Xiao Fangnan, Liu Xiaodong, Xie Anhua, Chen Fangman, Dong Panpan, Lin Pingdong, Zheng Chenyang, Zhang Hong, Gong Hui, Wu Yunkun.  (2021)  pH-Controlled Release of Antigens Using Mesoporous Silica Nanoparticles Delivery System for Developing a Fish Oral Vaccine.  Frontiers in Immunology,      [PMID:33953716] [10.3389/fimmu.2021.644396]

4. Qiujie Fang, Na Chen, Shan Hu, Sheng Hu, Jianfeng Ye, Xiaozhou Ye, Yun Wang.  (2021)  Preparation of Multifunctional Drug-loaded Microcapsules with Core-shell Three-dimensional Network Structure and their Application in Colon Targeted Release.  STARCH-STARKE,      [PMID:] [10.1002/star.202000016]

5. Ya-Nan Xia, Xiang-Hui Li, Jie-Hong Xu, Li-Qing Chen, Atef Mohammed Qasem Ahmed, Dingyun Cao, Huan-Huan Du, Yibin Deng, Qing-Ri Cao.  (2019)  Optimization and characterization of novel sustained release supermicro-pellet based dry suspensions that load dexibuprofen.  JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.jddst.2019.101420]

6. Guo Jian, Fang Huihui, Gui Shuangying, Huang Yuzhe.  (2019)  Solid dispersion-based pellet for colon delivery of tacrolimus through time- and pH-dependent layer coating: preparation, in vitro and in vivo studies.  Brazilian Journal of Pharmaceutical Sciences,      [PMID:] [10.1590/s2175-97902019000217309]

7. Huang Yaping, Zhang Sisi, Shen Huifen, Li Jinqing, Gao Chongkai.  (2018)  Controlled Release of the Nimodipine-Loaded Self-Microemulsion Osmotic Pump Capsules: Development and Characterization.  AAPS PHARMSCITECH,  19  (3): (1308-1319).  [PMID:29340982] [10.1208/s12249-017-0936-5]

8. Liu Jiang-Yan, Zhang Xiao-Xue, Huang Hao-Yan, Lee Beom-Jin, Cui Jing-Hao, Cao Qing-Ri.  (2017)  Esomeprazole magnesium enteric-coated pellet-based tablets with high acid tolerance and good compressibility.  Journal of Pharmaceutical Investigation,  48  (3): (341-350).  [PMID:] [10.1007/s40005-017-0326-8]

9. Xiaofeng Li, Xiaobang Liu, Yaotai Jiang, Dongshun Deng.  (2016)  Solubilities and Thermodynamic Properties of Carbon Dioxide in Some Biobased Solvents.  JOURNAL OF CHEMICAL AND ENGINEERING DATA,      [PMID:] [10.1021/acs.jced.6b00399]

10. Liu Huifang, Gao Zhaoying, Hu Xueyan, Wang Zhanyong, Su Tingting, Yang Lei, Yan Song.  (2016)  Blending Modification of PHBV/PCL and its Biodegradation by Pseudomonas mendocina.  JOURNAL OF POLYMERS AND THE ENVIRONMENT,  25  (2): (156-164).  [PMID:] [10.1007/s10924-016-0795-2]

11. Jing Lu, Shuling Kan, Yi Zhao, Wenli Zhang, Jianping Liu.  (2016)  Novel naproxen/esomeprazole magnesium compound pellets based on acid-independent mechanism: in vitro and in vivo evaluation.  DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY,      [PMID:26902772] [10.3109/03639045.2016.1151029]

12. Shuling Kan, Jing Lu, Jianping Liu, Junlin Wang, Yi Zhao.  (2014)  A quality by design (QbD) case study on enteric-coated pellets: Screening of critical variables and establishment of design space at laboratory scale.  Asian Journal of Pharmaceutical Sciences,      [PMID:] [10.1016/j.ajps.2014.07.005]

13. Meixia Xu, Minjie Sun, Hongzhi Qiao, Qineng Ping, Eltayeb Suliman Elamin.  (2014)  Preparation and evaluation of colon adhesive pellets of 5-aminosalicylic acid.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,      [PMID:24746693] [10.1016/j.ijpharm.2014.04.040]

14. Dong Yang, Xinwen Peng, Linxin Zhong, Xuefei Cao, Wei Chen, Xueming Zhang, Shijie Liu, Runcang Sun.  (2013)  “Green” films from renewable resources: Properties of epoxidized soybean oil plasticized ethyl cellulose films.  CARBOHYDRATE POLYMERS,      [PMID:24528720] [10.1016/j.carbpol.2013.12.043]

15. Huifang Li, Yu Yue, Xiao Wang, Dahuan Liu.  (2025)  An environmentally friendly lithium extraction system utilizing Cyanex 272 as iron-fixed reagent.  DESALINATION,      [PMID:] [10.1016/j.desal.2025.118574]

16. Yi Xing, Huizi Zheng, Chengzhi Wang, Zhipeng Zhang, Yudan Qian, Jiao Qu, Xiaolin Zhu.  (2024)  Cost-efficient and ultrasensitive sensor for electrochemical detection and cytotoxicity assessment of tetracyclines.  Journal of Environmental Chemical Engineering,      [PMID:] [10.1016/j.jece.2024.113642]

17. Junlong Huang, Guangzhong Xie, Xiangdong Xu, Zhenya Geng, Yuanjie Su.  (2024)  Degradable Multilayer Fabric Sensor with Wide Detection Range and High Linearity.  ACS Applied Materials & Interfaces,      [PMID:39425644] [10.1021/acsami.4c12066]

18. Xiang Cao, Fengqiang Nan, Wenhao Fan, Heng Gao, Ling Chen, Yan Guo, Weidong He.  (2024)  Preparation, formation mechanism, and performance of nitrocellulose aqueous coating based on the anti-solvent method.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,      [PMID:] [10.1016/j.colsurfa.2024.133214]

19. Junlin Wang, Shuling Kan, Tong Chen, Jianping Liu.  (2015)  Application of quality by design (QbD) to formulation and processing of naproxen pellets by extrusion–spheronization.  PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY,      [PMID:25069591] [10.3109/10837450.2014.908300]

20. Zuhao Chen, Yongyou Hu, Guanglei Qiu, Donghui Liang, Jianhua Cheng, Yuancai Chen, Guobin Wang, Xiaoqiang Zhu, Jieyun Xie.  (2025)  Inoculation with Acinetobacter indicus CZH-5 in internal circulation airlift zeolite spheres sequencing batch reactor to augment simultaneous removal of nitrogen, phosphorus, and tetracycline.  JOURNAL OF HAZARDOUS MATERIALS,      [PMID:40311430] [10.1016/j.jhazmat.2025.138384]

21. XIiaoyu Li, Weibin Rong, Lengfeng Wang, Hui Xie, Lining Sun.  (2025)  Development of magnetically driven microrobot covered with a time-dependent film for colon drug delivery.  Journal of Materials Chemistry B,      [PMID:41054828] [10.1039/D5TB00721F]

22. Wen Jihai, Huang Gang, Sun Pengbo, Wang Xiaoling, Zhang Guizhen.  (2025)  Green and continuous preparation of poly(vinylidene fluoride)/SiO2 composite membrane with interpenetrating bicontinuous porous architecture.  JOURNAL OF MATERIALS SCIENCE,      [PMID:] [10.1007/s10853-025-11685-w]

23. Huifang Li, Shuo Wang, Wenbin Fan, Dahuan Liu.  (2025)  Developing a green lithium extraction process: insights into the TBP - P507 system and its industrial potential.  JOURNAL OF SOLID STATE CHEMISTRY,      [PMID:] [10.1016/j.jssc.2025.125499]

24. Xinyan Fan, Ying Wang, Yixuan Jiao, Xiaoqian Zhou, Xiangyu Tang, Cunshi Zhao, Wuming Fan, Yunfeng Guo, Dong Wang, Qingbo Wang, Zefang Xiao, Yanjun Xie, Yonggui Wang.  (2026)  Aequorea Victoria-Inspired Covalent Anchoring Enables Water-Resistant and Scalable Room-Temperature Phosphorescence in Cellulose.  ADVANCED MATERIALS,      [PMID:41631561] [10.1002/adma.202520138]

25. Haozheng Zhang, Chuansheng Yang, Wenhao Yuan, Qihang Dong, Yuhong Xu, Chu Chu, Tabussam Tufail, Farhan Saeed, Yan Yang.  (2026)  Beeswax sacrificial support and latex curing for high-fidelity semi-solid extrusion 3D printed sustained-release tablets.  JOURNAL OF PHARMACEUTICAL SCIENCES,      [PMID:] [10.1016/j.xphs.2026.104321]