Trifluridine (NSC 75520) - Moligand™, 10mM in DMSO , CAS No.70-00-8

CAS: 70-00-8 Cat. No.: T408444 Peso molecular: 296.2 Número EC: 200-722-8 PubChem CID: 6256

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

NSC 529182, Viroptic, Trifluorothymidine, TFT | α,​α,​α-​trifluoro-thymidine

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Trifluridine (NSC 75520) Trifluridine (NSC 529182, NSC 75520, Viroptic, Trifluorothymidine, TFT) is an anti-herpesvirus antiviral agent by interacting viral DNA replication, used primarily on the eye.
In vitro

Trifluridine inhibits proliferations of mouse bone marrow cells and human colorectal carcinoma cells implanted to nude mice dose-dependently. Trifluridine inhibits colony formation of bone marrow cells in a concentration-dependent manner. Trifluridine (FTD) and 2\'-deoxy-5-fluorouridine (FdUrd) are incorporated into DNA with different efficiencies due to differences in the substrate specificities of TK1 and DUT, causing abundant FTD incorporation into DNA. FTD-treated cells shows differing nuclear morphologies compared to FdUrd-treated cells. Trifluridine inhibits proliferations of mouse bone marrow cells and human colorectal carcinoma cells implanted to nude mice dose-dependently.

In vivo

Trifluridine has significantly fewer swabs positive for HSV-1 than the untreated eyes in the infected rabbits. Trifluridine has increased antitumor activity and is incorporated into DNA more effectively than continuously infused Trifluridine in mice. Trifluridine gradually accumulates in tumor cell DNA, in a TPI-independent manner, and significantly delays tumor growth and prolonged survival in mice, compared to treatment with 5-FU derivatives. Trifluridine results in significantly lower viral titers, fewer HSV-1-positive eyes/total during the treatment period, lower keratitis scores, fewer eyes with keratitis/total, and a shorter time to resolution of keratitis in the New Zealand rabbit ocular model.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

NSC 529182, Viroptic, Trifluorothymidine, TFT | α, ​α, ​α-​trifluoro-thymidine

Especificaciones y pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Trifluridine (NSC 529182, NSC 75520, Viroptic, Trifluorothymidine, TFT) is an anti-herpesvirus antiviral agent by interacting viral DNA replication, used primarily on the eye.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Propiedades del producto

• ALogP: -0.5

Nombres e identificadores

• Isómeros SMILES: C1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)C(F)(F)F)CO)O
• RTECS: XP2087500
• CAS alternativo: 70-00-8
• PubChem CID: 6256
• Términos de entrada MeSH: 2'-deoxy-5-(trifluoromethyl)uridine;5 Trifluoromethyl 2' deoxyuridine;5-Trifluoromethyl-2'-deoxyuridine;TFT Ophtiole;Triflumann;Trifluoridine;Trifluorothymidine;Trifluridine;Viromidin;Virophta;Viroptic
• Peso molecular: 296.2
• Reaxy-Rn: 568095

Propiedades químicas y físicas

• Rotación específica [α]: +47.0 ～ +53.0°(C=1,H2O)
• Punto de fusión (°C): 189°C

Referencias

1. Huiqun Huang, Hongyuan Huang, Jie Yang, Huan Yang, Jing Dai, Zhuo Li, Wen Yao, Xinrong Guo.  (2024)  Synthesis of P, N-dopped carbon nanosheets for highly sensitive fluorescence analysis of nitrofuran antibiotics in fish.  FOOD CHEMISTRY,      [PMID:39024887] [10.1016/j.foodchem.2024.140445]