Determine the necessary mass, volume, or concentration for preparing a solution.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Moligand™, ≥99% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at 2-8°C,Protected from light,Argon charged Ships Wet ice Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 36 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Trimethoprim is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections.
An antibacterial agent which selectively inhibits dihydrofolate reductase.
| ALogP | 0.9 |
|---|
| Sonrisas canónicas | COC1=CC(=CC(=C1OC)OC)CC2=CN=C(N=C2N)N |
|---|---|
| IUPAC Name | 5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine |
| InChIKey | IEDVJHCEMCRBQM-UHFFFAOYSA-N |
| INCHI | 1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18) |
| Isómeros SMILES | COC1=CC(=CC(=C1OC)OC)CC2=CN=C(N=C2N)N |
| RTECS | UV8225000 |
| PubChem CID | 5578 |
| Número ONU | 2811 |
| Grupo de embalaje | I |
| Peso molecular | 290.32 |
| Beilstein | 25(5)13,429 |
| Reaxy-Rn | 625127 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Benzenoids |
| Clase | Phenol ethers |
| Subclass | Anisoles |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Anisoles |
| Alternative Parents | Phenoxy compounds Methoxybenzenes Aminopyrimidines and derivatives Alkyl aryl ethers Imidolactams Heteroaromatic compounds Azacyclic compounds Primary amines Organopnictogen compounds Hydrocarbon derivatives |
| Molecular Framework | Aromatic heteromonocyclic compounds |
| Substituents | Phenoxy compound - Anisole - Methoxybenzene - Alkyl aryl ether - Aminopyrimidine - Monocyclic benzene moiety - Pyrimidine - Imidolactam - Heteroaromatic compound - Organoheterocyclic compound - Ether - Azacycle - Organic oxygen compound - Amine - Primary amine - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Aromatic heteromonocyclic compound |
| Descripción | This compound belongs to the class of organic compounds known as anisoles. These are organic compounds containing a methoxybenzene or a derivative thereof. |
| External Descriptors | a small molecule |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Fecha | Articulo |
|---|---|---|---|
| Certificate of Analysis | Apr 03, 2026 | T129928 | |
| Certificate of Analysis | Mar 23, 2026 | T129928 | |
| Certificate of Analysis | Mar 23, 2026 | T129928 | |
| Certificate of Analysis | Mar 11, 2026 | T129928 | |
| Certificate of Analysis | Dec 12, 2025 | T129928 | |
| Certificate of Analysis | Dec 12, 2025 | T129928 | |
| Certificate of Analysis | Sep 09, 2025 | T129928 | |
| Certificate of Analysis | May 12, 2025 | T129928 | |
| Certificate of Analysis | May 12, 2025 | T129928 | |
| Certificate of Analysis | Nov 04, 2024 | T129928 | |
| Certificate of Analysis | Jul 18, 2024 | T129928 | |
| Certificate of Analysis | Jul 18, 2024 | T129928 | |
| Certificate of Analysis | Jul 18, 2024 | T129928 | |
| Certificate of Analysis | Feb 04, 2024 | T129928 | |
| Certificate of Analysis | Feb 04, 2024 | T129928 | |
| Certificate of Analysis | Feb 04, 2024 | T129928 | |
| Certificate of Analysis | Feb 04, 2024 | T129928 | |
| Certificate of Analysis | Feb 04, 2024 | T129928 | |
| Certificate of Analysis | Feb 04, 2024 | T129928 | |
| Certificate of Analysis | Dec 21, 2023 | T129928 | |
| Certificate of Analysis | Jan 12, 2023 | T129928 | |
| Certificate of Analysis | Feb 12, 2022 | T129928 | |
| Certificate of Analysis | Feb 12, 2022 | T129928 |
| Solubilidad | Soluble in water (0.4 mg/ml), ethanol (2.6 mg/ml at 20 °C), methanol (12.1 mg/ml), chloroform (22.2 mg/ml at 20 °C), and DMSO (50 mg/ml). |
|---|---|
| Sensibilidad | Moisture & Light sensitive |
| Punto de fusión (°C) | 199-203℃ |
| Peso molecular | 290.320 g/mol |
| XLogP3 | 0.900 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 7 |
| Rotatable Bond Count | 5 |
| Exact Mass | 290.138 Da |
| Monoisotopic Mass | 290.138 Da |
| Topological Polar Surface Area | 106.000 Ų |
| Heavy Atom Count | 21 |
| Formal Charge | 0 |
| Complexity | 307.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
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| 3. Xin Zhang, Chaoyu Li, Dongdong Yao, Xiaojin Hu, Huijun Xie, Zhen Hu, Shuang Liang, Jian Zhang. (2023) The environmental risk assessment of constructed wetlands filled with iron and manganese ores in typical antibiotic treatment. ENVIRONMENTAL RESEARCH, [PMID:37923106] [10.1016/j.envres.2023.117567] |
| 4. Nan Li, Juan Zheng, Lu-Dan Yu, Yuan-Jun Tong, Xinying Gong, Yu Hou, Guosheng Chen, Jianqiao Xu, Fang Zhu, Gangfeng Ouyang. (2023) Green, mildly synthesized bismuth-based MOF for extraction of polar glucocorticoids in environmental water. JOURNAL OF HAZARDOUS MATERIALS, [PMID:37716268] [10.1016/j.jhazmat.2023.132477] |
| 5. Guanxing Chen, Haohuai He, Lu Zhao, Qiujie Lv, Calvin Yu-Chian Chen. (2023) GINCM-DTA: A graph isomorphic network with protein contact map representation for potential use against COVID-19 and Omicron subvariants BQ.1, BQ.1.1, XBB.1.5, XBB.1.16. EXPERT SYSTEMS WITH APPLICATIONS, [PMID:] [10.1016/j.eswa.2023.121274] |
| 6. Bao Pan, Miao Liao, Yanli Zhao, Yuzhu Lv, Jiani Qin, Virender K. Sharma, Chuanyi Wang. (2023) Visible light activation of ferrate(VI) by oxygen doped ZnIn2S4/black phosphorus nanolayered heterostructure: Accelerated oxidation of trimethoprim. JOURNAL OF HAZARDOUS MATERIALS, [PMID:37666167] [10.1016/j.jhazmat.2023.132413] |
| 7. Shun Zhang, Yujie Feng, Bin Liang, Pengfei Si, Dengfei Li, Yanjuan Gao, Aijuan Zhou, Xiuping Yue. (2023) Efficient biodegradation of trimethoprim and transformation mechanism using the photoelectrocatalytic system. Journal of Water Process Engineering, [PMID:] [10.1016/j.jwpe.2023.103926] |
| 8. Jinqiang Wang, Zhaoyang Su, Nigel J.D. Graham, Hongkai Liu, Kai Sun, Wenzheng Yu. (2023) Double positively charged polyamide nanofiltration membrane with PEI/Zr4+ for Cr3+ and trimethoprim removal. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2023.144074] |
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| 11. Boxuan Yao, Ke Zhang, Xiaoyang Liu, Hua Wei, Zihan Li, Jiarui Zhou, Guangfei Yuan, Xin Wang, Shenghong Yang, Jian Liu. (2023) Versatile preparation strategy of negatively charged saccharide-based polymers for selective removal of cationic organic pollutants. APPLIED SURFACE SCIENCE, [PMID:] [10.1016/j.apsusc.2023.156428] |
| 12. Li Chen, Tahir Maqbool, Ghazanfar Nazir, Congyu Hou, Yanna Xu, Yulong Yang, Xihui Zhang. (2022) Peroxymonosulfate activated by composite ceramic membrane for the removal of pharmaceuticals and personal care products (PPCPs) mixture: Insights of catalytic and noncatalytic oxidation. WATER RESEARCH, [PMID:36470049] [10.1016/j.watres.2022.119444] |
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| 14. Hui Wen, Wei Huang, Changkun Liu. (2022) Double-barrier forward osmosis membrane for rejection and destruction of bacteria and removal of dyes. DESALINATION, [PMID:] [10.1016/j.desal.2022.115609] |
| 15. Lu-Zhu Chen, Hai-Long Wu, Wan-Jun Long, Tong Wang, Gao-Yan Tong, Ru-Qin Yu. (2021) Rapid determination of sulfamethoxazole and trimethoprim illegally added to health products using excitation–emission matrix fluorescence coupled with the second-order calibration method. Analytical Methods, 13 (42): (5075-5084). [PMID:34652354] [10.1039/D1AY01391B] |
| 16. Yanan Yan, Lin Li, Huilin Zhang, Fangfang Du, Yating Meng, Shaomin Shuang, Ruibing Wang, Shengmei Song, Chuan Dong. (2021) Carbon dots for ratiometric fluorescence detection of morin. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, [PMID:33819765] [10.1016/j.saa.2021.119751] |
| 17. Jie Chen, Jinfeng Ling, Bo Sun, Jian Wang, Baoxue Zhou, Xiaohong Guan, Yuankui Sun. (2020) Trace organic contaminants abatement by permanganate/bisulfite pretreatment coupled with conventional water treatment processes: Lab- and pilot-scale tests. JOURNAL OF HAZARDOUS MATERIALS, [PMID:32763684] [10.1016/j.jhazmat.2020.123380] |
| 18. Yinqiao Zhang, Huijiao Wang, Yang Li, Bin Wang, Jun Huang, Shubo Deng, Gang Yu, Yujue Wang. (2020) Removal of micropollutants by an electrochemically driven UV/chlorine process for decentralized water treatment. WATER RESEARCH, [PMID:32652347] [10.1016/j.watres.2020.116115] |
| 19. Chen Lili, Xu Hui, Wang Li, Li Yong, Tian Xike. (2020) Portable ratiometric probe based on the use of europium(III) coordination polymers doped with carbon dots for visual fluorometric determination of oxytetracycline. MICROCHIMICA ACTA, 187 (2): (1-8). [PMID:31938900] [10.1007/s00604-019-4104-3] |
| 20. Shizong Wang, Jianlong Wang. (2019) Kinetics of PMS activation by graphene oxide and biochar. CHEMOSPHERE, [PMID:31521932] [10.1016/j.chemosphere.2019.124812] |
| 21. Sandip Mondal, Jialing Jiang, Yin Li, Gangfeng Ouyang. (2019) Carbon and Tin-Based Polyacrylonitrile Hybrid Architecture Solid Phase Microextraction Fiber for the Detection and Quantification of Antibiotic Compounds in Aqueous Environmental Systems. MOLECULES, 24 (9): (1670). [PMID:31035407] [10.3390/molecules24091670] |
| 22. Sandip Mondal, Jianqiao Xu, Guosheng Chen, Siming Huang, Chuyu Huang, Li Yin, Gangfeng Ouyang. (2018) Solid-phase microextraction of antibiotics from fish muscle by using MIL-101(Cr)NH2-polyacrylonitrile fiber and their identification by liquid chromatography-tandem mass spectrometry. ANALYTICA CHIMICA ACTA, [PMID:30567665] [10.1016/j.aca.2018.09.060] |
| 23. Shizong Wang, Jianlong Wang. (2018) Degradation of emerging contaminants by acclimated activated sludge. ENVIRONMENTAL TECHNOLOGY, [PMID:28639849] [10.1080/09593330.2017.1345989] |
| 24. Suyu Ren, Jing Tao, Feng Tan, Ying Cui, Xiaona Li, Jingwen Chen, Xin He, Yi Wang. (2018) Diffusive gradients in thin films based on MOF-derived porous carbon binding gel for in-situ measurement of antibiotics in waters. SCIENCE OF THE TOTAL ENVIRONMENT, [PMID:30029123] [10.1016/j.scitotenv.2018.07.013] |
| 25. Yijia Tang, Siming Huang, Jianqiao Xu, Gangfeng Ouyang, Yuan Liu. (2018) PLGA-based nanofibers with a biomimetic polynoradrenaline sheath for rapid in vivo sampling of tetrodotoxin and sulfonamides in pufferfish. Journal of Materials Chemistry B, 6 (22): (3655-3664). [PMID:32254828] [10.1039/C8TB00757H] |
| 26. Shizong Wang, Jianlong Wang. (2017) Trimethoprim degradation by Fenton and Fe(II)-activated persulfate processes. CHEMOSPHERE, [PMID:29031058] [10.1016/j.chemosphere.2017.10.040] |
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