Trimethyl orthoformate - anhydrous, ≥99.8% , CAS No.149-73-5

CAS: 149-73-5 Cat. No.: T104065 Peso molecular: 106.12 Beilstein Registry Number: 969215 Número EC: 205-745-7 PubChem CID: 9005
Disponible para pedir
GRADE & PURITY Anhydrous Grade ? Anhydrous grade — water removed and packaged dry for moisture-sensitive chemistry. Use in reactions where even trace water would interfere or quench. ≥99.8%
Synonyms
MFCD00008483 | trimethoxy methane | CH(OMe)3 | PYOKUURKVVELLB-UHFFFAOYSA- | Trimethylester kyseliny orthomravenci [Czech] | trimethyl ortho formate | LS-13013 | Methoxymethylal | NSC 147479 | AKOS000121043 | AMY41181 | TRIMETHYL ORTHOFORMATE [HSDB] | Trim
Storage
Room temperature,Desiccated
Shipped In
FedEx DG Service
 ·  off list, applied to all prices below.
Size
Estado
Price
Qty
100ml
T104065-100ml
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
62,90US$
500ml
T104065-500ml
4
200,90US$
Enter a quantity for the sizes you want to add.
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Why this grade

anhydrous, ≥99.8% Anhydrous Grade for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Room temperature,Desiccated Ships FedEx DG Service Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 20 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Descripción general

Trimethyl orthoformate is an effective solvent for thallium(III) nitrate-mediated oxidations.It undergoes acid catalyzed reaction with 6-(N-D-ribitylanilino) uracils to form 8-demethyl-8-hydroxy-5-deazariboflavins.
Trimethyl orthoformate was used as dehydrating agent in the preparation of surface-modified colloidal silica nanoparticles.

Specifications

Sinónimos
MFCD00008483 | trimethoxy methane | CH(OMe)3 | PYOKUURKVVELLB-UHFFFAOYSA- | Trimethylester kyseliny orthomravenci [Czech] | trimethyl ortho formate | LS-13013 | Methoxymethylal | NSC 147479 | AKOS000121043 | AMY41181 | TRIMETHYL ORTHOFORMATE [HSDB] | Trim
Especificaciones y pureza
anhydrous, ≥99.8%
Condiciones de almacenamiento de almacenamiento
Room temperature, Desiccated
Enviado en
FedEx DG Service
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Grado
Anhydrous Grade
Pureza
≥99.8%
Nombres e identificadores
Pubchem Sid504751778
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/504751778
Sonrisas canónicasCOC(OC)OC
IUPAC Nametrimethoxymethane
InChIKeyPYOKUURKVVELLB-UHFFFAOYSA-N
INCHI1S/C4H10O3/c1-5-4(6-2)7-3/h4H,1-3H3
Isómeros SMILES COC(OC)OC
WGK Alemania 1
RTECS RM6650000
PubChem CID 9005
Número ONU 3272
Peso molecular 106.12
Beilstein 969215

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganic oxygen compounds
ClaseOrganooxygen compounds
SubclassOrtho esters
Intermediate Tree Nodes Not available
Direct ParentOrtho esters
Alternative Parents Carboxylic acid orthoesters  Hydrocarbon derivatives  
Molecular FrameworkAliphatic acyclic compounds
Substituents Ortho ester - Carboxylic acid orthoester - Orthocarboxylic acid derivative - Hydrocarbon derivative - Aliphatic acyclic compound
DescripciónThis compound belongs to the class of organic compounds known as ortho esters. These are compounds having the general structure RC(OR')3 ( R' not H), or the structure C(OR')4 ( R' not H).
External Descriptors Not available
Estructura 3D
Modelo de Estructura Química Interactiva





Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

7 results found

Lot NumberCertificate TypeFechaArticulo
I2207179Certificate of AnalysisJun 15, 2026 T104065
K2524528Certificate of AnalysisNov 14, 2025 T104065
K2524533Certificate of AnalysisNov 14, 2025 T104065
B2102278Certificate of AnalysisDec 11, 2024 T104065
D2511078Certificate of AnalysisJun 23, 2022 T104065
F2411080Certificate of AnalysisJun 23, 2022 T104065
I2207178Certificate of AnalysisJun 23, 2022 T104065
Propiedades químicas y físicas
SolubilidadSoluble in water, alcohol, and ether.
SensibilidadMoisture Sensitive
Índice de refracción1.379
Punto de inflamación (°F)48.2 °F
Punto de inflamación (°C)13℃
Punto de ebullición (°C)101°C
Punto de fusión (°C)-53°C
Peso molecular106.120 g/mol
XLogP30.200
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass106.063 Da
Monoisotopic Mass106.063 Da
Topological Polar Surface Area27.700 Ų
Heavy Atom Count7
Formal Charge0
Complexity28.400
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Preguntas frecuentes y artículos
Citations of This Product
Referencias
1. Xinsheng Tang, Tursun Abdiryim, Ruxangul Jamal, Xiong Liu, Fangfei Liu, Feng Xu, Abdukeyum Abdurexit, Qian Cheng, Nawrzhan Serkjan, Shuyue Xie, Yiming Liu.  (2023)  Photovoltaic–Pyroelectric coupled effect enhanced photo-responsivity of a p-n heterojunction Self-Powered ultraviolet photodetector.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2023.146762]
2. Xinshu Zou, Shuang Cai, Tingting Wang, Sidi Zheng, Xilong Cui, Jingyou Hao, Xueying Chen, Yanyan Liu, Zhiyun Zhang, Yanhua Li.  (2023)  Natural Antibacterial Agent-based Nanoparticles for Effective Treatment of Intracellular MRSA Infection.  Acta Biomaterialia,      [PMID:37557944] [10.1016/j.actbio.2023.08.004]
3. Wulan Zeng, Xia Wang, Xiangjun Kong, Youwang Li, Yunju Zhang.  (2023)  Study on crystal structure, spectroscopic, thermodynamic properties and Hirshfeld surfaces of a new spirocompound containing thiourea group C17H18N2O4S.  JOURNAL OF MOLECULAR STRUCTURE,      [PMID:] [10.1016/j.molstruc.2023.135017]
4. Keng Xuan, Shikun Chen, Yanfeng Pu, Yaoping Guo, Yadan Guo, Yun Li, Chenxi Pu, Ning Zhao, Fukui Xiao.  (2022)  Encapsulating phosphotungstic acid within metal-organic framework for direct synthesis of dimethyl carbonate from CO2 and methanol.  Journal of CO2 Utilization,      [PMID:] [10.1016/j.jcou.2022.101960]
5. Yizhou Tu, Huimin Wang, Pingping Yang, Guizhou Xu, Xuejiao Hu, Aimin Li, Xianchuan Xie.  (2021)  A porous thienyl cyclodextrin polymer synthesized in a homogeneous ionic liquid catalytic system for the rapid removal of pharmaceuticals and personal care products (PPCPs).  GREEN CHEMISTRY,  24  (1): (227-237).  [PMID:] [10.1039/D1GC03141D]
6. Yang Yang, Fuwei Yang, Xiaotian Shan, Jiamin Xu, Wenjie Fang, Juan Zhou, Lipeng Qiu, Jinghua Chen.  (2021)  Fabrication of pH/Reduction Sensitive Polyethylene Glycol-Based Micelles for Enhanced Intracellular Drug Release.  Pharmaceutics,  13  (9): (1464).  [PMID:34575539] [10.3390/pharmaceutics13091464]
7. Jialu Gao, Yong Xu, Yan Zheng, Xin Wang, Shuting Li, Guoqing Yan, Jun Wang, Rupei Tang.  (2019)  pH-sensitive carboxymethyl chitosan hydrogels via acid-labile ortho ester linkage as an implantable drug delivery system.  CARBOHYDRATE POLYMERS,      [PMID:31521291] [10.1016/j.carbpol.2019.115237]
8. Xiaotian Shan, Jing Mao, Miaomiao Long, Kamel S. Ahmed, Changling Sun, Lipeng Qiu, Jinghua Chen.  (2019)  Influence of polyethylene glycol molecular weight on the anticancer drug delivery of pH-sensitive polymeric micelle.  JOURNAL OF APPLIED POLYMER SCIENCE,  136  (32): (47854).  [PMID:] [10.1002/app.47854]
9. Keng Xuan, Yanfeng Pu, Feng Li, Jing Luo, Ning Zhao, Fukui Xiao.  (2019)  Metal-organic frameworks MOF-808-X as highly efficient catalysts for direct synthesis of dimethyl carbonate from CO2 and methanol.  CHINESE JOURNAL OF CATALYSIS,      [PMID:] [10.1016/S1872-2067(19)63291-2]
10. Lipeng Qiu, Mengqin Zhu, Kai Gong, Huanhuan Peng, Lu Ge, Li Zhao, Jinghua Chen.  (2017)  pH-triggered degradable polymeric micelles for targeted anti-tumor drug delivery.  Materials Science & Engineering C-Materials for Biological Applications,      [PMID:28576067] [10.1016/j.msec.2017.04.137]
11. Jinxia An, Qianqian Guo, Peng Zhang, Andrew Sinclair, Yu Zhao, Xinge Zhang, Kan Wu, Fang Sun, Hsiang-Chieh Hung, Chaoxing Li, Shaoyi Jiang.  (2016)  Hierarchical design of a polymeric nanovehicle for efficient tumor regression and imaging.  Nanoscale,  (17): (9318-9327).  [PMID:27088429] [10.1039/C6NR01595F]
12. Jinxia An, Xiaomei Dai, Yu Zhao, Qianqian Guo, Zhongming Wu, Xinge Zhang, Chaoxing Li.  (2015)  A biodegradable and fluorescent nanovehicle with enhanced selective uptake by tumor cells.  Polymer Chemistry,  (36): (6529-6542).  [PMID:] [10.1039/C5PY00795J]
13. Thi Thanh Cham Bui, Hue Linh Luu, Thi Thanh Luong, Thi Ngoc Nguyen, Nguyet Suong Huyen Dao, Van Giang Nguyen, Dinh Luyen Nguyen, Nguyen Trieu Trinh, Van Hai Nguyen.  (2024)  An Alternative Method for Synthesizing N,2,3-Trimethyl-2H-indazol-6-amine as a Key Component in the Preparation of Pazopanib.  Chemistry-Switzerland,  (5): (1089-1098).  [PMID:] [10.3390/chemistry6050063]
14. Zhong-Qiong Qin, Ze-Tao Xiao, Xi-Yang Lan, Xin Wang, Yuan Hu, Lei Song.  (2025)  Cardanol-derived polybenzoxazine networks integrated with high glass transition temperatures, flame retardancy and toughness.  POLYMER DEGRADATION AND STABILITY,      [PMID:] [10.1016/j.polymdegradstab.2025.111232]
15. Chengxin Zhang, Lulu Yang, Lin Zhao, Yu Liu, Dongfeng Hong, Xiaoyuan Shi, Shaolei Wang, Guangshan Zhu.  (2024)  Economical and rapid mechanochemical synthesis of porous organic adsorbents with high hydrophilicity for ultra-fast removal of organic micro-pollutants from water.  SEPARATION AND PURIFICATION TECHNOLOGY,      [PMID:] [10.1016/j.seppur.2024.129236]
16. Pan Deng, Lin Chen, Zi-Jie Cao, Yue Li, Guan-Qi Zheng, Yu-Zhong Wang, Xiu-Li Wang.  (2025)  Bioinspired Dual-Stimulus-Responsive Macromolecular Engineering Enables Chemically Recyclable, High-Performance and Fire-Retardant Plastic.  MACROMOLECULES,      [PMID:] [10.1021/acs.macromol.5c00753]
17. Miaomiao Long, Shenhuan Liu, Xiaotian Shan, Jing Mao, Fuwei Yang, Xiaoyu Wu, Lipeng Qiu, Jinghua Chen.  (2020)  Self-assembly of pH-sensitive micelles for enhanced delivery of doxorubicin to melanoma cells.  JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.jddst.2020.101859]
18. Lingyu Chen, Yunhong Liu, Xinyan Peng, Yuelan Wei, Ke Shao.  (2025)  Simultaneous hypercrosslinking and functionalization of porous polystyrene adsorbent for protein-bound uraemic toxins removal.  REACTIVE & FUNCTIONAL POLYMERS,      [PMID:] [10.1016/j.reactfunctpolym.2025.106265]
19. Zhongqi Zhang, Yingjie Shen, Aosen Zhang, Yuan Zhai, Ziqing Wang, Kun Jiang, Heyun Wang.  (2025)  Preparation of imidazole ligand zirconium-based UiO-66 and its application in the direct synthesis of dimethyl carbonate from CO2 and methanol.  Journal of CO2 Utilization,      [PMID:] [10.1016/j.jcou.2025.103148]
20. Yan Zhou, Jia Liu, Xiang-Yu Zhao, Wen-Jia Yang, Michael J. Adang, Guang-Mao Shen.  (2025)  The DMPA secreted by the pitcher of Nepenthes × ventrata demonstrates insecticidal activity against a range of insect pests.  PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY,      [PMID:41326119] [10.1016/j.pestbp.2025.106782]
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