Tyrosinase (TYR), CAS No.9002-10-2

CAS: 9002-10-2 Cat. No.: T1508158 Número EC: 232-653-4
Disponible para pedir
GRADE & PURITY Bioactive ? Bioactive grade — verified to retain biological activity in functional assays. Use when the molecule must be functionally active, not just pure. Recombinant ? Recombinant — produced via recombinant expression for defined sequence and consistency. Use for reproducible, animal-free proteins of known origin. Suitable for molecular biology ? Molecular-biology grade — free of nucleases and contaminants that degrade DNA/RNA. Use in cloning, PCR, and nucleic-acid work needing clean reagents. ActiBioPure™ ? ActiBioPure™ — Aladdin's premier line for bioactive and recombinant products. Use when both high purity and preserved biological activity are required. High Performance ? High-performance grade with optimized purity and performance characteristics. Use for sensitive analyses where ordinary grades fall short. EnzymoPure™ ? EnzymoPure™ — Aladdin's line of high-quality enzymatic solutions. Use when enzyme purity and defined activity drive assay or process performance. ≥500U/mg enzyme powder;Protein Content ≥90% ; expressed in Yeast
Accession #
P06845
Expression system
Yeast
Bioactivity
≥500U/mg enzyme powder
 ·  off list, applied to all prices below.
Size
Estado
Price
Qty
5KU
T1508158-5KU
1-2 wks(?)
Item is derived from our semi-finished stock and is processed in 1-2 weeks.
49,90US$
25KU
T1508158-25KU
1-2 wks(?)
Item is derived from our semi-finished stock and is processed in 1-2 weeks.
149,90US$
100KU
T1508158-100KU
1-2 wks(?)
Item is derived from our semi-finished stock and is processed in 1-2 weeks.
499,90US$
Enter a quantity for the sizes you want to add.
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Why this grade

Bioactive,Recombinant,ActiBioPure™,High Performance,Suitable for molecular biology,EnzymoPure™,≥500U/mg enzyme powder;Protein Content ≥90% ; expressed in Yeast ActiBioPure™,Bioactive,High Performance,Recombinant,Suitable for molecular biology,EnzymoPure™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -20°C,Desiccated,Avoid repeated freezing and thawing Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 64 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Descripción general

  This product is a high-purity monophenol oxidase (Tyrosinase, EC 1.14.18.1) refined from a specific strain via modern fermentation technology and chromatography processes. As a copper-containing metalloenzyme, it can efficiently catalyze the hydroxylation of monophenols (e.g., tyrosine) to diphenols (e.g., L-DOPA) and further oxidize diphenols to quinones.
  Compared with traditional mushroom-derived tyrosinase, Streptomyces-derived tyrosinase has unique advantages:
  High catalytic activity: It exhibits higher enzyme activity and reaction rate within a specific pH and temperature range.
  Excellent stability: It has stronger tolerance to changes in temperature and pH, showing more stable performance in production applications.
  Broad substrate specificity: It has good catalytic effects on various phenolic substrates.
  Animal-origin free: Produced from microbial fermentation, it avoids the risk of animal-derived diseases, complies with halal, kosher certifications and vegetarian requirements, and is more suitable for applications in food, cosmetics and pharmaceuticals.
  This product is in the form of lyophilized powder, which is convenient for transportation and storage, and needs to be reconstituted before use.

Specifications

Product Name
Tyrosinase (TYR), CAS No.9002-10-2
Sinónimos
cresolase | monophenol monooxygenase | monophenol oxidase | N-acetyl-6-hydroxytryptophan oxidase | phenolase | tyrosine-dopa oxidase | melC2
Grado
ActiBioPure™, Bioactive, High Performance, Recombinant, Suitable for molecular biology, EnzymoPure™
Especificaciones y pureza
Bioactive, Recombinant, ActiBioPure™, High Performance, Suitable for molecular biology, EnzymoPure™, ≥500U/mg enzyme powder;Protein Content ≥90% ; expressed in Yeast
Mecanismos bioquímicos y fisiológicos
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds.
Bioactividad
≥500U/mg enzyme powder
Número de adhesión
Peso molecular previsto
44.1 kDa
CAS
9002-10-2
Número de la Comisión de Enzimas
EC 1.14.18.1
Tipo de molécula
Enzyme
Almacenamiento y envío
Concentración
≥500U/mg enzyme powder;Protein Content ≥90% ; expressed in Yeast
Condiciones de almacenamiento de almacenamiento
Store at -20°C,Desiccated,Avoid repeated freezing and thawing
Enviado en
Ice chest + Ice pads
Estabilidad y almacenamiento
Store at -20℃ long term (12 months). Upon reconstitution, it is recommended to aliquot. Avoid freeze/thaw cycle. Desiccated.
Definición de unidad
Under the conditions of pH 6.5 and 25°C, the absorbance at 280 nm (A₂₈₀) increases by 0.001 units per minute in a 3 mL reaction mixture containing L-tyrosine.

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

6 results found

Lot NumberCertificate TypeFechaArticulo
ZJ26F0737012Certificate of AnalysisJul 02, 2026 T1508158
ZJ26F0737011Certificate of AnalysisJul 02, 2026 T1508158
ZJ26F0434466Certificate of AnalysisApr 22, 2026 T1508158
ZJ26F0131285Certificate of AnalysisJan 15, 2026 T1508158
ZJ26F0131284Certificate of AnalysisJan 15, 2026 T1508158
ZJ26F0131283Certificate of AnalysisJan 15, 2026 T1508158
Preguntas frecuentes y artículos
Citations of This Product
Referencias
1. Muhammad Aurang Zeb, Peng-Yun Yang, De-Wen Bi, Wen-Chao Tu, Xiao-Li Li, Rui-Han Zhang, Xing-Jie Zhang, Wei-Lie Xiao.  (2023)  Chemical constituents from Vitex negundo var. cannabifolia (Sieb. et Zucc.) Hand.-Mazz. (Lamiaceae) and their chemotaxonomic significance.  BIOCHEMICAL SYSTEMATICS AND ECOLOGY,      [PMID:] [10.1016/j.bse.2023.104719]
2. Yan Cao, Jinpeng Lv, Yan Tan, Ruolin Chen, Xiaoxue Jiang, Duo Meng, Kun Zou, Min Pan, Liming Tang.  (2023)  Tribuloside acts on the PDE/cAMP/PKA pathway to enhance melanogenesis, melanocyte dendricity and melanosome transport.  JOURNAL OF ETHNOPHARMACOLOGY,      [PMID:38158096] [10.1016/j.jep.2023.117673]
3. Jinpeng Lv, Ximei Zhang, Xiaohong An, Yan Cao, Duo Meng, Kun Zou, Rongyin Gao, Ruzhi Zhang.  (2023)  The inhibition of VDAC1 oligomerization promotes pigmentation through the CaMK–CRTCs/CREB–MITF pathway.  EXPERIMENTAL CELL RESEARCH,      [PMID:38070860] [10.1016/j.yexcr.2023.113874]
4. Jianjin GUO, Lu BAI, Chi-Tang HO, Sen GUO, Naisheng BAI.  (2023)  Chemical characterization, multivariate analysis and in vitro bioactivity evaluation of the roots of Fraxinus mandshurica.  CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,      [PMID:] [10.1016/j.cjac.2023.100303]
5. Hong Wang, Mengmeng Gu, Menghua Yan, Xiuming Wu, Yuming Dong, Guang-Li Wang.  (2023)  Catechol exerts an in situ surface oxygen vacancy effect on BiOI: an innovative signal transduction mode for cathodic photoelectrochemistry.  Journal of Materials Chemistry B,  11  (23): (5123-5130).  [PMID:37221921] [10.1039/D3TB00566F]
6. De-Wen Bi, Jian- Feng, Wen-Hui Pang, Peng-Yun Yang, Yao-Jun Xu, Muhammad Aurang Zeb, Meng-Ru Wang, Xing-Jie Zhang, Xiao-Li Li, Rui-Han Zhang, Wei-Guang Wang, Wei-Lie Xiao.  (2023)  Three new lanostane triterpenoids and two new amides from Alternaria sp. with NLRP3 inflammasome inhibitory activity.  NATURAL PRODUCT RESEARCH,      [PMID:37161750] [10.1080/14786419.2023.2211215]
7. Yuhe Shen, Dongshuang Jia, Yuefei Wang, Tao Yu, Xiaojian Xu, Heng Chang, Qing Li, Rongxin Su, Wei Qi.  (2023)  Enzymatic oxidation of tyrosine enantiomers into biomimetic pigments with enhanced performance for hair dyeing.  DYES AND PIGMENTS,      [PMID:] [10.1016/j.dyepig.2023.111360]
8. Hong Liu, Xuliang Yang, Bo Huang, Hongxiang Liu.  (2023)  A universal approach for synthesis of copper nanoclusters templated by G-rich oligonucleotide sequences and their applications in sensing.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:37080047] [10.1016/j.saa.2023.122740]
9. Kanglin Pei, Di Li, Wenjing Qi, Di Wu.  (2023)  Ultrarapid Microwave-Assisted Synthesis of Fluorescent Silver Coordination Polymer Nanoparticles and Its Application in Detecting Alkaline Phosphatase Activity.  MOLECULES,  28  (4): (1892).  [PMID:36838879] [10.3390/molecules28041892]
10. Qin-Tao Zhou, Peng-Yun Yang, Quan-Yu Yang, Wen-Hui Pang, Xiao-Li Li, Xing-Jie Zhang, Rui-Han Zhang, Wei-Lie Xiao.  (2023)  Chemical Constituents of the Branches and Leaves of Picrasma chinensis P.Y. Chen and Tyrosinase Inhibiting Activity.  CHEMISTRY & BIODIVERSITY,  20  (3): (e202201171).  [PMID:36691852] [10.1002/cbdv.202201171]
11. Wang Wenxian, Yang Dan, Zhou Yufei, Zhang Yuding, Guan Lijiao, Zhang Xianfen, Xue Weiming, Huang Saipeng.  (2022)  Novel Green Fluorescent Probe Stem From Carbon Quantum Dots for Specific Recognition of Tyrosinase in Serum and Living Cells.  JOURNAL OF FLUORESCENCE,  33  (2): (739-750).  [PMID:36515759] [10.1007/s10895-022-03101-2]
12. Sun Tingwei, Guo Qingquan, Wu Shaojuan, Su Kui, Lun Jingwen, Zhang Yihan, Tan Wen, Zhao Haishan.  (2022)  Comparative Study of High-throughput Screening Models for Anti-hyperpigmentation Compounds.  BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY,      [PMID:] [10.1590/1678-4324-2022210281]
13. Zhi-Ang Liu, Ya-Nan Zuo, Yinghui Xia, Jing Sun, Shuyun Zhu.  (2022)  Enhanced detection of ascorbic acid with cascaded fluorescence recovery of a dual-nanoquencher system.  Analytical Methods,  14  (37): (3632-3637).  [PMID:36052693] [10.1039/D2AY01019D]
14. Meng Sha, Weiqing Xu, Yu Wu, Lei Jiao, Yifeng Chen, Jiajia Huang, Yinjun Tang, Wenling Gu, Chengzhou Zhu.  (2022)  Histidine-engineered metal-organic frameworks with enhanced peroxidase-like activity for sensitive detection of metallothioneins.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2022.131927]
15. Jiaman Liu, Yanbiao Chen, Xinxin Zhang, Jie Zheng, Weiying Hu, Bo Teng.  (2022)  Hop Tannins as Multifunctional Tyrosinase Inhibitor: Structure Characterization, Inhibition Activity, and Mechanism.  Antioxidants,  11  (4): (772).  [PMID:35453457] [10.3390/antiox11040772]
16. Yi Wang, Chengpei Du, Ze Liu, Kanglin Pei, Yan Zhang, Wenjing Qi.  (2022)  Chemiluminescence “turn-on” detection of tyrosinase activity via in situ generation of dopamine based on a lucigenin and riboflavin system.  NEW JOURNAL OF CHEMISTRY,  46  (9): (4156-4161).  [PMID:] [10.1039/D1NJ05628J]
17. Luo Yiyuan, Wang Juan, Li Shuo, Wu Yue, Wang Zhirui, Chen Shaojun, Chen Hongjiang.  (2022)  Discovery and identification of potential anti-melanogenic active constituents of Bletilla striata by zebrafish model and molecular docking.  BMC Complementary Medicine and Therapies,  22  (1): (1-14).  [PMID:34996448] [10.1186/s12906-021-03492-y]
18. Zheng-Hao Yin, Yuan-Fei Li, Hong-Xia Gan, Nan Feng, Yong-Ping Han, Li-Mei Li.  (2021)  Synergistic effects and antityrosinase mechanism of four plant polyphenols from Morus and Hulless Barley.  FOOD CHEMISTRY,      [PMID:34875434] [10.1016/j.foodchem.2021.131716]
19. Lv Jinpeng, Yang Ying, Jia Bingyi, Li Siqi, Zhang Ximei, Gao Rongyin.  (2021)  The Inhibitory Effect of Curcumin Derivative J147 on Melanogenesis and Melanosome Transport by Facilitating ERK-Mediated MITF Degradation.  Frontiers in Pharmacology,      [PMID:34887767] [10.3389/fphar.2021.783730]
20. Xiang Liu, Jinqiu Rao, Kai Wang, Meijun Wang, Tie Yao, Feng Qiu.  (2021)  Highly Potent Inhibition of Tyrosinase by Mulberrosides and the Inhibitory Mechanism in Vitro.  CHEMISTRY & BIODIVERSITY,  19  (1): (e202100740).  [PMID:34752017] [10.1002/cbdv.202100740]
21. Can Chen, Guotong Ruan, Yujie Sun, Lili Wang, Chengwu Zhang, Jinhua Liu.  (2021)  In situ Cu2+-triggered wavelength-tunable fluorescent sensor for highly sensitive sensing inorganic pyrophosphatase activity and its logic gate application.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2021.130439]
22. Liu Hui, Huang Pengcheng, Wu Fang-Ying, Ma Lihua.  (2021)  Colorimetric determination of acid phosphatase activity and inhibitor screening based on in situ polymerization of aniline catalyzed by gold nanoparticles.  MICROCHIMICA ACTA,  188  (5): (1-10).  [PMID:33822286] [10.1007/s00604-021-04799-w]
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24. Lv Jinpeng, Jiang Songzhou, Yang Ying, Zhang Ximei, Gao Rongyin, Cao Yan, Song Guoqiang.  (2020)  FGIN-1-27 Inhibits Melanogenesis by Regulating Protein Kinase A/cAMP-Responsive Element-Binding, Protein Kinase C-β, and Mitogen-Activated Protein Kinase Pathways.  Frontiers in Pharmacology,      [PMID:33390991] [10.3389/fphar.2020.602889]
25. Lv Jinpeng, An Xiaohong, Jiang Songzhou, Yang Ying, Song Guoqiang, Gao Rongyin.  (2020)  Protoporphyrin IX Stimulates Melanogenesis, Melanocyte Dendricity, and Melanosome Transport Through the cGMP/PKG Pathway.  Frontiers in Pharmacology,      [PMID:33013408] [10.3389/fphar.2020.569368]
26. Congcong Yu, Qingpeng Cao, Tingting Tu, Yu Cai, Lu Fang, Xuesong Ye, Bo Liang.  (2020)  Differential coulometry based on dual screen-printed strips for high accuracy levodopa determination towards Parkinson's disease management.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,      [PMID:32781320] [10.1016/j.jpba.2020.113498]
27. Huang Xuemin, Zhao Huanan, Qiu Wen, Wang Jian, Guo Longhua, Lin Zhenyu, Pan Wei, Wu Yong, Qiu Bin.  (2020)  A fluorescence signal amplification strategy for modification-free ratiometric determination of tyrosinase in situ based on the use of dual-templated copper nanoclusters.  MICROCHIMICA ACTA,  187  (4): (1-9).  [PMID:32198661] [10.1007/s00604-020-4186-y]
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50. Jinpeng Lv, Kun Zou, Chuanwei Yin, Wenhui Xu, Duo Meng, Huansha Zhang, Wenhao Yu, Peiwen Jiang, Changjun Yun, Hui Xue, Nan Hu, Rongyin Gao.  (2025)  Daidzin suppresses melanogenesis through ERK and AKT signaling pathways mediated MITF proteasomal degradation.  EXPERIMENTAL AND MOLECULAR PATHOLOGY,      [PMID:40695033] [10.1016/j.yexmp.2025.104986]
51. Jian-Ye Zhu, Zeng-Yue Ge, Qi-Bin Yang, Cai-Fu Jiang, Lei Wu, Xin-Yuan Jiang, Lin-Fu Liang.  (2025)  Bioassay-Guided Isolation of Chemical Constituents from Lycopodiastrum casuarinoides and Targeted Evaluation of Their Potential Efficacy in Cosmetics.  Cosmetics,  12  (4): (174).  [PMID:] [10.3390/cosmetics12040174]
52. Ling Zhang, Qi-Bin Yang, Jia-Dong Shao, Can-Qi Liu, Lei Wu, Kong-Kai Zhu, Lin-Fu Liang.  (2025)  HSQC-based SMART accelerated discovery of a new picane triterpene with tyrosinase inhibitory activity from Palhinhaea cernua.  JOURNAL OF MOLECULAR STRUCTURE,      [PMID:] [10.1016/j.molstruc.2025.144200]
53. Huihui Wang, Yunyun Lu, Lun Wang, Hongqi Chen.  (2019)  Detection of tyramine and tyrosinase activity using red region emission NaGdF4:Yb,Er@NaYF4 upconversion nanoparticles.  TALANTA,      [PMID:30771976] [10.1016/j.talanta.2019.01.079]
54. Yongqi Tian, Ding Deng, Haitao Luo, Mingfeng He, Shaoyun Wang.  (2025)  Ultrasonic assisted enzymatic extraction, structural characterization, and tyrosinase inhibition mechanism of phlorotannins from Sargassum horneri.  Algal Research-Biomass Biofuels and Bioproducts,      [PMID:] [10.1016/j.algal.2025.104038]
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