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UBA5-IN-1 - ≥98% , CAS No.1831169-11-9
Disponible para pedir
GRADE & PURITY ≥98%
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
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Why this grade
≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Descripción general
UBA5-IN-1 (compound 8.5) is a selective UBA5 inhibitor with an IC 50 value of 4.0 μM. UBA5-IN-1 inhibits cell proliferation of Sk-Luci6 cancer cells with high expression levels of UBA5
In Vitro
UBA5-IN-1 (0.1-1000 μM) shows dose-dependent inhibition effect to UBA5 with an IC 50 value of 4.0 μM, and inhibits UAE and NAE with IC 50 values of 78.5 and 66.8 μM, respectively. UBA5-IN-1 (0-5 μM) inhibits UBA5 non-competitively with respect to ATP. UBA5-IN-1 (10 μM) shows no effect on ATP binding to human kinase. UBA5-IN-1 (0-50 μM; 72 h) effects cell proliferation of Sk-Luci6 cancer cells with high expression levels of UBA5. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: Sk-Luci6 cancer cells with high expression levels of UBA5 Concentration: 0-50 μM Incubation Time: 0-72 h Result: Showed selective anti-proliferative activity for Sk-Luci6 cancer cells which expressed higher UBA5 protein levels, but showed no anti-proliferative activity to MRC9 lung fibroblasts and A549 carcinoma cells.
Form:Solid
IC50& Target:IC50: 4.0 μM (UBA5), 78.5 μM (UAE), 66.8 μM (NAE)
Specifications
Especificaciones y pureza
≥98%
Mecanismos bioquímicos y fisiológicos
UBA5-IN-1 (compound 8.5) is a selective UBA5 inhibitor with an IC 50 value of 4.0 μM. UBA5-IN-1 inhibits cell proliferation of Sk-Luci6 cancer cells with high expression levels of UBA5.
Condiciones de almacenamiento de almacenamiento
Store at -20°C
Enviado en
Ice chest + Ice pads
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Pureza
≥98%
Nombres e identificadores
| Sonrisas canónicas | O=S(C(F)(F)F)([O-])=O.O=S(C(F)(F)F)([O-])=O.NC1=C(N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](C(NCCCCCC([N]45[Zn+2]67[N@@](CC[N]6([H])CC[N@]7([H])CC5)([H])CC4)=O)=O)O3)C2=NC=N1 |
|---|---|
| Peso molecular | 912.16 |
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Propiedades químicas y físicas
| Solubilidad | DMF : 100 mg/mL (109.63 mM; Need ultrasonic) DMSO : 50 mg/mL (54.81 mM; ultrasonic and warming and heat to 60°C) |
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Calculadoras de soluciones
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