REINO UNIDO 383367 - ≥98% , CAS No.348622-88-8

CAS: 348622-88-8 Cat. No.: U125948 Peso molecular: 324.38 Número EC: 683-685-4 PubChem CID: 9818682

Saltar al final de la galería de imágenes

REINO UNIDO 383367 - ≥98% CAS No(348622-88-8) by Aladdin Scientific

Saltar al comienzo de la galería de imágenes

Disponible para pedir

GRADE & PURITY ≥98%

Synonyms

(R)-5-(6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)-1,2,4-oxadiazole-3-carboxamide | s2224 | MLS006011234 | UK 383367 | SCHEMBL6430715 | 3-(Aminocarbonyl)-?-(3-cyclohexylpropyl)-N-hydroxy-1,2,4-oxadiazole-5-propanamide | J-516574 | AC-31417 | MFCD001021

Storage

Conservar a -20°C

Shipped In

Hielera + almohadillas de hielo

Descripción general Specifications Nombres e identificadores Documentation Advanced Data Taxonomic Classification Estructura 3D Objetivos asociados (humanos) Objetivos asociados (no humanos) Mecanismos de acción Certificados (CoA, COO, BSE/TSE y tabla de análisis) Propiedades químicas y físicas Preguntas frecuentes y artículos Calculadoras de soluciones Reseñas

🧪

Why this grade

≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Conservar a -20°C Ships Hielera + almohadillas de hielo Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Descripción general

Descripción del producto:

UK 383367 es un nuevo inhibidor de la proteína C del procolágeno (PCP) que se está investigando para el tratamiento de las cicatrices dérmicas posquirúrgicas, que inhibe potentemente la actividad de la PCP con un valor de la concentración de inhibición del 50% IC50 de 44 nM, así como un inhibidor selectivo de las metaloproteinasas de matriz (MMP) con valores de IC50 >60.000 nM para la MMP-2 y >10.000 nM para la MMP-1, MMP-3, MMP-9 y MMP-4. Aunque el mecanismo aún no está claro, UK 383367 también exhibe débiles efectos inhibidores contra la enzima fosfodiesterasa-4 (PDE-4), incluyendo PDE-4a, PDE-4b, PDE-4c y PDE-4d, con valores de IC50 de 1,8 μM, 1,5 μM, 2,4 μM y 0,9 μM respectivamente.

Specifications

Sinónimos

(R)-5-(6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)-1, 2, 4-oxadiazole-3-carboxamide | s2224 | MLS006011234 | UK 383367 | SCHEMBL6430715 | 3-(Aminocarbonyl)-?-(3-cyclohexylpropyl)-N-hydroxy-1, 2, 4-oxadiazole-5-propanamide | J-516574 | AC-31417 | MFCD001021

Especificaciones y pureza

≥98%

Mecanismos bioquímicos y fisiológicos

Inhibidor potente y selectivo de BMP-1 (procolágeno C-proteinasa; PCP) (IC50= 44 nM). Selectivo para BMP-1 sobre las MMPs 1, 2, 3, 9 y 14 (los valores IC50 son >10.000 nM para las MMPs enumeradas).

Condiciones de almacenamiento de almacenamiento

Conservar a -20°C

Enviado en

Hielera + almohadillas de hielo

Pureza

≥98%

Nombres e identificadores

Pubchem Sid	504764905
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504764905
Sonrisas canónicas	C1CCC(CC1)CCCC(CC(=O)NO)C2=NC(=NO2)C(=O)N
IUPAC Name	5-[(3R)-6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl]-1,2,4-oxadiazole-3-carboxamide
InChIKey	ARJCBSRIPGJMAD-LLVKDONJSA-N
INCHI	1S/C15H24N4O4/c16-13(21)14-17-15(23-19-14)11(9-12(20)18-22)8-4-7-10-5-2-1-3-6-10/h10-11,22H,1-9H2,(H2,16,21)(H,18,20)/t11-/m1/s1
Isómeros SMILES	C1CCC(CC1)CCC[C@H](CC(=O)NO)C2=NC(=NO2)C(=O)N
WGK Alemania	3
PubChem CID	9818682
Peso molecular	324.38

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organic acids and derivatives
  - Clase Carboxylic acids and derivatives
    - Subclass Carboxylic acid derivatives
      - Level5 Carboxylic acid amides
        Level6 2-heteroaryl carboxamides

Kingdom	Organic compounds
Superclass	Organic acids and derivatives
Clase	Carboxylic acids and derivatives
Subclass	Carboxylic acid derivatives
Intermediate Tree Nodes	Carboxylic acid amides
Direct Parent	2-heteroaryl carboxamides
Alternative Parents	Heteroaromatic compounds 1,2,4-oxadiazoles Hydroxamic acids Oxacyclic compounds Azacyclic compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	2-heteroaryl carboxamide - 1,2,4-oxadiazole - Azole - Oxadiazole - Heteroaromatic compound - Hydroxamic acid - Primary carboxylic acid amide - Oxacycle - Organoheterocyclic compound - Azacycle - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organic oxide - Carbonyl group - Organic nitrogen compound - Organic oxygen compound - Aromatic heteromonocyclic compound
Descripción	This compound belongs to the class of organic compounds known as 2-heteroaryl carboxamides. These are compounds containing a heteroaromatic ring that carries a carboxamide group.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Estructura 3D

Objetivos asociados (humanos)

PDE4D Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4D (1 Activities)

Discover Target: PDE4D

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BMP1 Tchem Bone morphogenetic protein 1 (3 Activities)

Discover Target: BMP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE4A Tclin Phosphodiesterase 4A (1943 Activities)

Discover Target: PDE4A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

BMP1 Tchem Bone morphogenetic protein 1 (1282 Activities)

Discover Target: BMP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PDE4B Tclin Phosphodiesterase 4B (2748 Activities)

Discover Target: PDE4B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MMP3 Tchem Matrix metalloproteinase 3 (3433 Activities)

Discover Target: MMP3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MMP14 Tchem Matrix metalloproteinase 14 (1592 Activities)

Discover Target: MMP14

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PDE4C Tclin Phosphodiesterase 4C (258 Activities)

Discover Target: PDE4C

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MMP1 Tchem Matrix metalloproteinase-1 (7046 Activities)

Discover Target: MMP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Liver microsomes (16955 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Liver (3974 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Skin (286 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Objetivos asociados (no humanos)

Pde4d Phosphodiesterase 4D (4 Activities)

Discover Target: Pde4d

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mmp2 Matrix metalloproteinase-2 (12 Activities)

Discover Target: Mmp2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mmp9 Matrix metalloproteinase 9 (38 Activities)

Discover Target: Mmp9

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Canis familiaris (36305 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción

Certificados (CoA, COO, BSE/TSE y tabla de análisis)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot Number	Certificate Type	Fecha	Articulo
H23021148	Certificate of Analysis	May 12, 2025	U125948
H23021160	Certificate of Analysis	May 12, 2025	U125948
H23021161	Certificate of Analysis	May 12, 2025	U125948
H23021223	Certificate of Analysis	May 12, 2025	U125948

Propiedades químicas y físicas

Solubilidad	Solvent:DMSO, Max Conc. mg/mL: 32.44, Max Conc. mM: 100
Peso molecular	324.380 g/mol
XLogP3	2.400
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	8
Exact Mass	324.18 Da
Monoisotopic Mass	324.18 Da
Topological Polar Surface Area	131.000 Å²
Heavy Atom Count	23
Formal Charge	0
Complexity	401.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Preguntas frecuentes y artículos

Applications of BMP Signaling Pathway Regulators in Stem Cell Differentiation, Organoid Culture and Developmental Research

Categories: Technical articles

Tags:

BMP signaling pathway Stem cell differentiation Organoid culture Developmental biology BMP inhibitor SMAD signaling

Calculadoras de soluciones

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

Reconstitution Calculator

Reseñas

Bulk & Custom Packaging Need larger quantities or custom specifications? Contact our team for a tailored quote.

REINO UNIDO 383367 - ≥98% , CAS No.348622-88-8

Why this grade

Storage & shipping

Quality documents

Literature proof

Descripción general

Specifications

Documentation

📋 Safety Data Sheet (SDS)

✅ Certificate of Analysis (COA)

📊 Datasheet

🔬 Specification Sheet

Advanced Data

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

Reseñas de cliente

View related series