Urantide, Antagonist of UT receptor, CAS No.669089-53-6, Antagonist of UT receptor

CAS: 669089-53-6 Cat. No.: U288432 Peso molecular: 1075.26 PubChem CID: 11520939
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GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
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Size
Estado
Price
Qty
1mg
U288432-1mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
247,90US$
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Why this grade

Moligand™ Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Product Name
Urantide, Antagonist of UT receptor, CAS No.669089-53-6
Sinónimos
[Pen5, DTrp7, Orn8]hU-II(4-11)
Grado
Moligand™
Especificaciones y pureza
Moligand™
Mecanismos bioquímicos y fisiológicos
Selective and competitive urotensin-II (UT) receptor antagonist (pKB= 8.3). Blocks hU-II induced contractions in thoracic aortaex vivo. Exhibits no effect on noradrenaline or endothelin 1-induced contraction or on acetylcholine-induced relaxation. Behaves
Secuencia
DXFWXYCV(Modifications: X-2 = Pen, X-5 = Orn, Trp-4 = D-Trp, Disulfide bridge: 2-7)
Tipo de acción
ANTAGONIST
Mecanismo de acción
Antagonist of UT receptor
CAS
669089-53-6
Tipo de molécula
Protein
Almacenamiento y envío
Condiciones de almacenamiento de almacenamiento
Store at -20°C
Enviado en
Ice chest + Ice pads

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganic acids and derivatives
ClaseCarboxylic acids and derivatives
SubclassAmino acids, peptides, and analogues
Intermediate Tree Nodes Peptides
Direct ParentOligopeptides
Alternative Parents Cyclic peptides  Aspartic acid and derivatives  Valine and derivatives  N-acyl-L-alpha-amino acids  Macrolactams  Alpha amino acid amides  3-alkylindoles  1-hydroxy-2-unsubstituted benzenoids  Substituted pyrroles  N-acyl amines  Benzene and substituted derivatives  Dicarboxylic acids and derivatives  Heteroaromatic compounds  Lactams  Amino acids  Organic disulfides  Secondary carboxylic acid amides  Carboxylic acids  Azacyclic compounds  Hydrocarbon derivatives  Carbonyl compounds  Monoalkylamines  Organic oxides  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents Alpha-oligopeptide - Cyclic alpha peptide - Aspartic acid or derivatives - N-acyl-alpha amino acid or derivatives - Valine or derivatives - N-acyl-l-alpha-amino acid - N-acyl-alpha-amino acid - Macrolactam - Alpha-amino acid amide - Alpha-amino acid or derivatives - 3-alkylindole - Indole - Indole or derivatives - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Benzenoid - Substituted pyrrole - Fatty acyl - N-acyl-amine - Fatty amide - Dicarboxylic acid or derivatives - Monocyclic benzene moiety - Heteroaromatic compound - Pyrrole - Organic disulfide - Amino acid or derivatives - Carboxamide group - Secondary carboxylic acid amide - Lactam - Amino acid - Carboxylic acid - Organoheterocyclic compound - Azacycle - Organonitrogen compound - Hydrocarbon derivative - Organic nitrogen compound - Primary aliphatic amine - Organic oxygen compound - Carbonyl group - Organic oxide - Primary amine - Amine - Organooxygen compound - Aromatic heteropolycyclic compound
DescripciónThis compound belongs to the class of organic compounds known as oligopeptides. These are organic compounds containing a sequence of between three and ten alpha-amino acids joined by peptide bonds.
External Descriptors Not available
Estructura 3D
Modelo de Estructura Química Interactiva





Objetivos asociados (humanos)
UTS2R Tchem Urotensin-2 receptor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
UTS2R Tchem Urotensin II receptor (1388 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Objetivos asociados (no humanos)
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mecanismos de acción
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Información genética
Alternate Names[Pen5,DTrp7,Orn8]hU-II(4-11)
Reference
  • 1. Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration., The Journal of biological chemistry, Steegborn, C C and 7 more authors.
  • 2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., Proceedings of the National Academy of Sciences of the United States of America, Strausberg, Robert L RL and 83 more authors.
  • 3. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)., Human genetics, Wang, Jian J and Hegele, Robert A RA.
  • 4. Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase., Biochemical and biophysical research communications, Lu, Y Y, O'Dowd, B F BF, Orrego, H H and Israel, Y Y.
  • 5. Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration., Clinical genetics, Wang, J J, Huff, A M AM, Spence, J D JD and Hegele, R A RA.
  • 6. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1., The Journal of biological chemistry, Yang, Guangdong G, Cao, Kun K, Wu, Lingyun L and Wang, Rui R.
  • 7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)., Genome research, Gerhard, Daniela S DS and 115 more authors.
  • 8. Towards a proteome-scale map of the human protein-protein interaction network., Nature, Rual, Jean-François JF and 37 more authors.
  • 9. The DNA sequence and biological annotation of human chromosome 1., Nature, Gregory, S G SG and 178 more authors.
  • 10. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., International journal of cancer, Moore, Lee E LE and 14 more authors. more
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