Venlafaxine hydrochloride - ≥98%(HPLC) , Norepinephrine transporter inhibitor, CAS No.99300-78-4, Norepinephrine transporter inhibitor

CAS: 99300-78-4 Cat. No.: V129637 Peso molecular: 313.86 Número EC: 619-421-1 PubChem CID: 62923
Disponible para pedir
GRADE & PURITY ≥98%(HPLC)
Synonyms
1-[2-(Dimethylamino)-1-(4-methoxyph enyl)ethyl]cyclohexanol hydrochloride | BV164514 | EffexorXR Extended-Release | Venlafaxinehydrochloride | EffexorXR | Cyclohexanol, 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]-, hydrochloride (1:1 | NCGC00261134-01
Storage
Store at 2-8°C
Shipped In
Wet ice
 ·  off list, applied to all prices below.
Size
Estado
Price
Qty
1g
V129637-1g
2
13,90US$
5g
V129637-5g
3
30,90US$
25g
V129637-25g
2
92,90US$
100g
V129637-100g
2
287,90US$
Enter a quantity for the sizes you want to add.
🧪

Why this grade

≥98%(HPLC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at 2-8°C Ships Wet ice Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 9 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Descripción general

Venlafaxine hydrochloride is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI).
An inhibitor of ST and SLC6A2.

Specifications

Sinónimos
1-[2-(Dimethylamino)-1-(4-methoxyph enyl)ethyl]cyclohexanol hydrochloride | BV164514 | EffexorXR Extended-Release | Venlafaxinehydrochloride | EffexorXR | Cyclohexanol, 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]-, hydrochloride (1:1 | NCGC00261134-01
Especificaciones y pureza
≥98%(HPLC)
Mecanismos bioquímicos y fisiológicos
Venlafaxine Hydrochloride is a dual ST and SLC6A2 (serotonin and noradrenalin re-uptake) inhibitor that displays ~ 30-fold higher affinity for ST (SERT) (Ki = 82 nm) than SLC6A2 (NET) (Ki = 2480 nM).Serotonin-norepinephrine reuptake inhibitor. K i values
Condiciones de almacenamiento de almacenamiento
Store at 2-8°C
Enviado en
Wet ice
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Tipo de acción
INHIBITOR
Mecanismo de acción
Norepinephrine transporter inhibitor
Nota
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Pureza
≥98%(HPLC)
Nombres e identificadores
Pubchem Sid504753893
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/504753893
Sonrisas canónicasCN(C)CC(C1=CC=C(C=C1)OC)C2(CCCCC2)O.Cl
IUPAC Name1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexan-1-ol;hydrochloride
InChIKeyQYRYFNHXARDNFZ-UHFFFAOYSA-N
INCHI1S/C17H27NO2.ClH/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14;/h7-10,16,19H,4-6,11-13H2,1-3H3;1H
Isómeros SMILES CN(C)CC(C1=CC=C(C=C1)OC)C2(CCCCC2)O.Cl
WGK Alemania 3
RTECS GV8872760
CAS alternativo 93413-69-5
PubChem CID 62923
Peso molecular 313.86
Reaxy-Rn 4240401

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassBenzenoids
ClasePhenol ethers
SubclassAnisoles
Intermediate Tree Nodes Not available
Direct ParentAnisoles
Alternative Parents Phenoxy compounds  Methoxybenzenes  Cyclohexanols  Aralkylamines  Alkyl aryl ethers  Tertiary alcohols  1,3-aminoalcohols  Trialkylamines  Cyclic alcohols and derivatives  Organopnictogen compounds  Hydrochlorides  Hydrocarbon derivatives  
Molecular FrameworkAromatic homomonocyclic compounds
Substituents Phenoxy compound - Anisole - Methoxybenzene - Alkyl aryl ether - Aralkylamine - Cyclohexanol - Monocyclic benzene moiety - 1,3-aminoalcohol - Cyclic alcohol - Tertiary alcohol - Tertiary aliphatic amine - Tertiary amine - Ether - Organic nitrogen compound - Organonitrogen compound - Organooxygen compound - Hydrochloride - Hydrocarbon derivative - Organopnictogen compound - Amine - Organic oxygen compound - Alcohol - Aromatic homomonocyclic compound
DescripciónThis compound belongs to the class of organic compounds known as anisoles. These are organic compounds containing a methoxybenzene or a derivative thereof.
External Descriptors hydrochloride
Estructura 3D
Modelo de Estructura Química Interactiva





Objetivos asociados (humanos)
SLC6A4 Tclin Sodium-dependent serotonin transporter (8 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SLC6A2 Tclin Norepinephrine transporter (10102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GMNN Tbio Geminin (128009 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Objetivos asociados (no humanos)
Pseudomonas aeruginosa (123386 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Klebsiella pneumoniae (43867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Acinetobacter baumannii (41033 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Escherichia coli (133304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cryptococcus neoformans (21258 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Candida albicans (78123 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Brain (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasma (328 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mecanismos de acción
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot NumberCertificate TypeFechaArticulo
F2609061Certificate of AnalysisJun 13, 2026 V129637
I2212425Certificate of AnalysisMar 11, 2026 V129637
I2212432Certificate of AnalysisMar 11, 2026 V129637
I2212438Certificate of AnalysisMar 11, 2026 V129637
I2212445Certificate of AnalysisMar 11, 2026 V129637
I2007248Certificate of AnalysisJan 29, 2026 V129637
I2007247Certificate of AnalysisJan 29, 2026 V129637
J2521806Certificate of AnalysisJul 13, 2024 V129637
J2521807Certificate of AnalysisJul 13, 2024 V129637
G2201681Certificate of AnalysisJul 06, 2022 V129637
Propiedades químicas y físicas
SolubilidadSoluble in water (>25 mg/ml), and DMSO (50 mM)
SensibilidadLight sensitive
Punto de fusión (°C)217°C
Peso molecular313.900 g/mol
XLogP3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count5
Exact Mass313.181 Da
Monoisotopic Mass313.181 Da
Topological Polar Surface Area32.700 Ų
Heavy Atom Count21
Formal Charge0
Complexity279.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count2
Preguntas frecuentes y artículos
Citations of This Product
Referencias
1. Niu Ting, Wei Zhiying, Fu Jiao, Chen Shu, Wang Ru, Wang Yuya, Zheng Ruihe.  (2023)  Venlafaxine, an anti-depressant drug, induces apoptosis in MV3 human melanoma cells through JNK1/2-Nur77 signaling pathway.  Frontiers in Pharmacology,      [PMID:36686679] [10.3389/fphar.2022.1080412]
2. Haibo You, Ben Chen, Liqun Fang, Tingting Lin, Ping Xu, Chu Chu, Shengqiang Tong.  (2022)  Analytical enantioseparation of N-alkyl drugs by reversed-phase liquid chromatography with carboxymethyl-β-cyclodextrin as mobile phase additive.  CHIRALITY,  35  (1): (58-66).  [PMID:36345792] [10.1002/chir.23516]
3. Jun Luo, Yuxuan Dai, Xiaoming Xu, Yazi Liu, Shaogui Yang, Huan He, Cheng Sun, Qiming Xian.  (2021)  Green and efficient synthesis of Co-MOF-based/g-C3N4 composite catalysts to activate peroxymonosulfate for degradation of the antidepressant venlafaxine.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,      [PMID:34922080] [10.1016/j.jcis.2021.11.162]
4. Lisha Jin, Sisi Zhou, Shujie Zhu, Shaowei Lei, Weijuan Du, Huidi Jiang, Su Zeng, Hui Zhou.  (2019)  Dehydrocorydaline induced antidepressant-like effect in a chronic unpredictable mild stress mouse model via inhibiting uptake-2 monoamine transporters.  EUROPEAN JOURNAL OF PHARMACOLOGY,      [PMID:31604070] [10.1016/j.ejphar.2019.172725]
5. Xuesong Liu, Liuliu Cheng, Yehong Han, Mingyu Wang, Hongyuan Yan.  (2024)  Development of a novel second-generation polyester dendritic functionalized graphene oxide for efficient pipette tip micro solid-phase extraction and detection of venlafaxine and desvenlafaxine in urine.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:39647375] [10.1016/j.chroma.2024.465582]
6. Bo Zhao, Guojing Yang, Zhouyun Xie, Ni Zhang, Jingfen Xia, Xuran Liu, Dongbo Wang, Peier Wang, Li Tang.  (2024)  Efficient degradation of venlafaxine using intimately coupled high-active crystal facets exposed TiO2 and biodegradation system: Kinetic studies, biofilm stress behavior and transformation mechanism.  JOURNAL OF ENVIRONMENTAL MANAGEMENT,      [PMID:38759549] [10.1016/j.jenvman.2024.121159]
7. Bin Wang, Yongyue Chen, Wenxuan Li, Yuwei Liu, Xudong Xia, Xia Xu, Yongli Yang, Di Chen.  (2024)  Magnetic phytic acid-modified kapok fiber biochar as a novel sorbent for magnetic solid-phase extraction of antidepressants in biofluids.  ANALYTICA CHIMICA ACTA,      [PMID:38401926] [10.1016/j.aca.2024.342295]
8. Yumei Gan, Linlin Hua, Yuanyuan Zheng, Bin Wang, Di Chen.  (2024)  Natural kapok fiber as a green and efficient adsorbent for in-syringe solid-phase extraction in the determination of antidepressants in biofluids.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2024.110638]
9. Zhanwu Li, Bowen Deng, Jiajia Chen, Ru Feng, Shuling Wang, Shu Li, Di Chen, Linlin Hua.  (2025)  One-pot synthesis of magnetic adsorbent with integrated pH regulation for convenient and rapid determination of antidepressant in biofluids.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2025.112834]
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