Verbascoside - Moligand™, 10mM in DMSO , Channel blocker of TRPV3, CAS No.61276-17-3, Channel blocker of TRPV3

CAS: 61276-17-3 Cat. No.: V425072 Peso molecular: 624.59 Número EC: 612-110-1 PubChem CID: 5281800

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

Acteoside|Verbascoside|Kusaginin|61276-17-3|TJC 160|acetoside|Verbacoside|NSC 603831|TJC-160|UNII-3TGX09BD5B|3TGX09BD5B|RUSSETINOL|STEREOSPERMIN|CHEBI:132853|NSC-603831|VERBASCOSIDE (USP-RS)|VERBASCOSIDE [USP-RS]|(2R,3R,4R,5R,6R)-6-(3,4-Dihydroxyphenethox

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Antioxidant and antiproliferative. Phenylethanoid glycoside.

Specifications

Sinónimos

Acteoside | Verbascoside | Kusaginin | 61276-17-3 | TJC 160 | acetoside | Verbacoside | NSC 603831 | TJC-160 | UNII-3TGX09BD5B | 3TGX09BD5B | RUSSETINOL | STEREOSPERMIN | CHEBI:132853 | NSC-603831 | VERBASCOSIDE (USP-RS) | VERBASCOSIDE [USP-RS] | (2R, 3R, 4R, 5R, 6R)-6-(3, 4-Dihydroxyphenethox

Especificaciones y pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos y fisiológicos

PKC inhibitor. NF-κB inhibitor. Increases PARP-1 and p53. Induces cell cycle arrest and differentiation. Inhibits MMP (IC 50 = 32 μM). Shows anti-inflammatory, antinociceptive and antioxidant effects in vivo. Orally active.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

CHANNEL BLOCKER

Mecanismo de acción

Channel blocker of TRPV3

Nombres e identificadores

• Sonrisas canónicas: CC1C(C(C(C(O1)OC2C(C(OC(C2OC(=O)C=CC3=CC(=C(C=C3)O)O)CO)OCCC4=CC(=C(C=C4)O)O)O)O)O)O
• IUPAC Name: [(2R,3R,4R,5R,6R)-6-[2-(3,4-dihydroxyphenyl)ethoxy]-5-hydroxy-2-(hydroxymethyl)-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
• InChIKey: FBSKJMQYURKNSU-ZLSOWSIRSA-N
• INCHI: 1S/C29H36O15/c1-13-22(36)23(37)24(38)29(41-13)44-27-25(39)28(40-9-8-15-3-6-17(32)19(34)11-15)42-20(12-30)26(27)43-21(35)7-4-14-2-5-16(31)18(33)10-14/h2-7,10-11,13,20,22-34,36-39H,8-9,12H2,1H3/b7-4+/t13-,20+,22-,23+,24+,25+,26+,27+,28+,29-/m0/s1
• Isómeros SMILES: C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)O[C@@H]2[C@H]([C@@H](O[C@@H]([C@H]2OC(=O)/C=C/C3=CC(=C(C=C3)O)O)CO)OCCC4=CC(=C(C=C4)O)O)O)O)O)O
• WGK Alemania: 2
• RTECS: LZ5786000
• PubChem CID: 5281800
• Peso molecular: 624.59

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Phenylpropanoids and polyketides
    • Clase Cinnamic acids and derivatives
      • Subclass Hydroxycinnamic acids and derivatives

• Kingdom: Organic compounds
• Superclass: Phenylpropanoids and polyketides
• Clase: Cinnamic acids and derivatives
• Subclass: Hydroxycinnamic acids and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Coumaric acids and derivatives
• Alternative Parents: Cinnamic acid esters O-glycosyl compounds Disaccharides Tyrosols and derivatives Styrenes Catechols 1-hydroxy-2-unsubstituted benzenoids 1-hydroxy-4-unsubstituted benzenoids Fatty acid esters Oxanes Enoate esters Secondary alcohols Polyols Acetals Oxacyclic compounds Monocarboxylic acids and derivatives Primary alcohols Organic oxides Carbonyl compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Coumaric acid or derivatives - Cinnamic acid ester - Disaccharide - Glycosyl compound - O-glycosyl compound - Tyrosol derivative - Catechol - Styrene - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Fatty acid ester - Phenol - Monocyclic benzene moiety - Fatty acyl - Oxane - Benzenoid - Enoate ester - Alpha,beta-unsaturated carboxylic ester - Secondary alcohol - Carboxylic acid ester - Polyol - Acetal - Organoheterocyclic compound - Monocarboxylic acid or derivatives - Oxacycle - Carboxylic acid derivative - Organooxygen compound - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Carbonyl group - Primary alcohol - Alcohol - Aromatic heteromonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as coumaric acids and derivatives. These are aromatic compounds containing Aromatic compounds containing a cinnamic acid moiety (or a derivative thereof) hydroxylated at the C2 (ortho-), C3 (meta-), or C4 (para-) carbon atom of the benzene ring.
• External Descriptors: hydroxycinnamic acid

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

TRPV3 Tchem Transient receptor potential cation channel subfamily V member 3 (0 Activities)

Discover Target: TRPV3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Sensibilidad: Hygroscopic,Heat Sensitive
• Rotación específica [α]: -92° (C=0.1,MeOH)
• Peso molecular: 624.600 g/mol
• XLogP3: -0.500
• Hydrogen Bond Donor Count: 9
• Hydrogen Bond Acceptor Count: 15
• Rotatable Bond Count: 11
• Exact Mass: 624.205 Da
• Monoisotopic Mass: 624.205 Da
• Topological Polar Surface Area: 245.000 Ų
• Heavy Atom Count: 44
• Formal Charge: 0
• Complexity: 936.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 10
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 1
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 1
• Covalently-Bonded Unit Count: 1

Referencias

1. Fei Zhou, Weisu Huang, Tao Xu, Lipeng Wu, Qi Chen, Jiyu Peng, Xin Liu, Baiyi Lu.  (2020)  Natural P-gp inhibitor EGCG improves the acteoside absorption in Caco-2 cell monolayers and increases the oral bioavailability of acteoside in rats.  FOOD AND CHEMICAL TOXICOLOGY,      [PMID:33184029] [10.1016/j.fct.2020.111827]

2. Si-qi Wang, Xiao Yang, Yong-gang Zhang, En-bo Cai, Xiao-man Zheng, Yan Zhao, Ge Li, Mei Han, Li-min Yang.  (2020)  Study on the Changes of Chemical Constituents in Different Compatibilities of Ginseng-Prepared Rehmannia Root and Their Effects on Bone Marrow Inhibition after Chemotherapy.  CHEMICAL & PHARMACEUTICAL BULLETIN,  68  (5): (428-435).  [PMID:32188797] [10.1248/cpb.c19-00994]

3. Fei Zhou, Tao Xu, Yajing Zhao, Huaxin Song, Liuquan Zhang, Xiaodan Wu, Baiyi Lu.  (2018)  Chitosan-coated liposomes as delivery systems for improving the stability and oral bioavailability of acteoside.  FOOD HYDROCOLLOIDS,      [PMID:] [10.1016/j.foodhyd.2018.04.040]

4. Zhou Fei, Zhao Yajing, Li Maiquan, Xu Tao, Zhang Liuquan, Lu Baiyi, Wu Xiaodan, Ge Zhiwei.  (2017)  Degradation of phenylethanoid glycosides in Osmanthus fragrans Lour. flowers and its effect on anti-hypoxia activity.  Scientific Reports,  7  (1): (1-10).  [PMID:28855701] [10.1038/s41598-017-10411-0]

5. Yong Jiang, Wenjun Ji, Ying Lu, Qin Wang, Linwei Chen.  (2025)  Integrating Plasma Metabolomics, Network Pharmacology, and Experimental Validation to Investigate the Action Mechanism of Qiangxin Lishui Prescription in Chronic Heart Failure.  BIOMEDICAL CHROMATOGRAPHY,  39  (2): (e6065).  [PMID:39748248] [10.1002/bmc.6065]

6. Liu Junyu, Wang Hua, Zhang Caihua.  (2025)  Acteoside-Loaded Self-Healing Hydrogel Enhances Skin Wound Healing through Modulation of Hair Follicle Stem Cells.  Cellular and Molecular Bioengineering,      [PMID:40290106] [10.1007/s12195-025-00845-2]

7. Zhang Yuxi, Zhan Junbiao, Qiu Zhen, Tian Hao, Lei Shaoqing, Huang Qin, Xue Rui, Sun Qian, Xia Zhongyuan.  (2025)  Verbascoside attenuates myocardial ischemia/reperfusion-induced ferroptosis following heterotopic heart transplantation via modulating GDF15/GPX4/SLC7A11 pathway.  Scientific Reports,  15  (1): (1-14).  [PMID:40325032] [10.1038/s41598-025-00112-4]

8. Qinle Huang, Zhangtie Wang, Binhai Shi, Guoliang Jie, Songbai Liu, Fuli Nie, Fan Wang, Zhenjiang Zhou, Siyu Chen, Jianfu Shen, Baiyi Lu.  (2025)  Improving Nutrition and Sensory Goals: Utilizing Explainable Machine Learning and Multi-Objective Optimization to Optimize Quality of Osmanthus fragrans Extract.  Food Frontiers,      [PMID:] [10.1002/fft2.70056]

9. Xiangrui Ren, Temirlan Khamiddolov, Li Niu, Qian Lin, Wenqing Zhao, Yìxiang Liu, Wenhao Li.  (2026)  Multi-scale insights: Impact of drying on water status, antioxidant mechanisms, and phenolic metabolomics in Osmanthus fragrans var. thunbergii.  FOOD RESEARCH INTERNATIONAL,      [PMID:41819927] [10.1016/j.foodres.2026.118775]