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Vimirogant hydrochloride - ≥98% , CAS No.V659033
Disponible para pedir
GRADE & PURITY ≥98%
Storage
Store at 2-8°C,Desiccated
Shipped In
Wet ice
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Why this grade
≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at 2-8°C,Desiccated Ships Wet ice Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Descripción general
Vimirogant (VTP-43742) hydrochloride is a potent, selective, and orally active RORγt inhibitor ( K i =3.5 nM; IC 50 =17 nM). Vimirogant hydrochloride exhibits >1000-fold selectivity versus the RORα and RORβ isotypes. Vimirogant hydrochloride inhibits Th17
Appearance:Solid
IC50& Target:RORγt 3.5 nM (Ki) RORγt 17 nM (IC 50 )
In Vitro:Vimirogant hydrochloride inhibits the secretion of IL-17A from activated hPBMCs (IC 50 =18 nM) and human whole blood (IC 50 =192 nM). MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo:In the MOG35-55/CFA immunized mouse EAE model, Vimirogant hydrochloride (p.o.) significantly suppresses clinical symptoms, demyelination and mRNA expression of multiple inflammatory markers in the spinal cord. MCE has not independently confirmed the
Biological Activity:Vimirogant (VTP-43742) hydrochloride is a potent, selective, and orally active RORγt inhibitor ( K i =3.5 nM; IC 50 =17 nM). Vimirogant hydrochloride exhibits >1000-fold selectivity versus the RORα and RORβ isotypes. Vimirogant hydrochloride inhibits Th17
Specifications
Especificaciones y pureza
≥98%
Condiciones de almacenamiento de almacenamiento
Store at 2-8°C, Desiccated
Enviado en
Wet ice
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Pureza
≥98%
Nombres e identificadores
| Sonrisas canónicas | O=C(C1=CN=C([C@H](C(C)C)N(C[C@H]2CC[C@H](C(F)(F)F)CC2)C3)C3=C1)NCC4=NC=C(S(=O)(CC)=O)C=C4.Cl.[x] |
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Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Propiedades químicas y físicas
| Solubilidad | DMSO : 125 mg/mL (Need ultrasonic) Ethanol : 50 mg/mL (Need ultrasonic) |
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Calculadoras de soluciones
Reseñas
Reseñas de cliente
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