Vinorelbine ditartrate salt hydrate - 10mM in DMSO , Tubulin inhibitor, CAS No.125317-39-7, Tubulin inhibitor

CAS: 125317-39-7 Cat. No.: V421059 Peso molecular: 1079.11（dry basis） Número EC: 639-264-2

GRADE & PURITY 10mM in DMSO

Synonyms

Vinorelbine tartrate|125317-39-7|Vinorelbine ditartrate|Vinorelbine Bitartrate|5'-Noranhydrovinoblastine tartrate|Vinorelbine ditartrate salt hydrate|KW-2307;Nor-5'-anhydrovinblastine ditartrate|VinorelbineTartrate|1217449-57-4|vinorelbine, ditartrate|vin

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Vinorelbine ditartrate is a selective mitotic microtubule antagonist that exhibits > 20 fold selectivity over axonal microtubules. This compound has been shown to inhibit the proliferation of multiple human tumor cell lines (IC50 = 1.25 nM in HeLa cells).

Specifications

Sinónimos

Vinorelbine tartrate | 125317-39-7 | Vinorelbine ditartrate | Vinorelbine Bitartrate | 5'-Noranhydrovinoblastine tartrate | Vinorelbine ditartrate salt hydrate | KW-2307;Nor-5'-anhydrovinblastine ditartrate | VinorelbineTartrate | 1217449-57-4 | vinorelbine, ditartrate | vin

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Vinorelbine is a potent anti-mitotic, anti-tumor agent. Vinorelbine inhibits microtubule assembly. Low neurotoxicity is related to its higher affinity for mitotic microtubules than for axonal microtubules.Selective mitotic microtubule antagonist. Inhibits

Condiciones de almacenamiento de almacenamiento

Protected from light, Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Mecanismo de acción

Tubulin inhibitor

Nombres e identificadores

• Sonrisas canónicas: CCC1=CC2CC(C3=C(CN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC.C(C(C(=O)O)O)(C(=O)O)O.C(C(C(=O)O)O)(C(=O)O)O
• IUPAC Name: (2R,3R)-2,3-dihydroxybutanedioic acid;methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(12S,14S)-16-ethyl-12-methoxycarbonyl-1,10-diazatetracyclo[12.3.1.03,11.04,9]octadeca-3(11),4,6,8,15-pentaen-12-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate
• InChIKey: CILBMBUYJCWATM-LNLXBTRNSA-N
• INCHI: 1S/C45H54N4O8.2C4H6O6/c1-8-27-19-28-22-44(40(51)55-6,36-30(25-48(23-27)24-28)29-13-10-11-14-33(29)46-36)32-20-31-34(21-35(32)54-5)47(4)38-43(31)16-18-49-17-12-15-42(9-2,37(43)49)39(57-26(3)50)45(38,53)41(52)56-7;2*5-1(3(7)8)2(6)4(9)10/h10-15,19-21,28,37-39,46,53H,8-9,16-18,22-25H2,1-7H3;2*1-2,5-6H,(H,7,8)(H,9,10)/t28-,37+,38-,39-,42-,43-,44+,45+;2*1-,2-/m111/s1
• Isómeros SMILES: CCC1=C[C@@H]2C[C@@](C3=C(CN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[C@]78CCN9[C@H]7[C@@](C=CC9)([C@H]([C@@]([C@@H]8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O
• WGK Alemania: 3
• CAS alternativo: 71486-22-1
• Peso molecular: 1079.11（dry basis）

Propiedades químicas y físicas

• Sensibilidad: Light sensitive
• Punto de fusión (°C): 181°C-183°C
• Peso molecular: 1079.100 g/mol
• Hydrogen Bond Donor Count: 10
• Hydrogen Bond Acceptor Count: 23
• Rotatable Bond Count: 16
• Exact Mass: 1078.43 Da
• Monoisotopic Mass: 1078.43 Da
• Topological Polar Surface Area: 364.000 Ų
• Heavy Atom Count: 77
• Formal Charge: 0
• Complexity: 1820.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 12
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 3

XLogP3

Referencias

1. Nan Zhao, Qirui Sun, Lening Zhang, Hao Jin, Mengsi Zhang, Shuwei Liu, Hua Xin.  (2023)  Fe3O4 Composite Superparticles with RGD/Magnetic Dual-Targeting Capabilities for the Imaging and Treatment of Non-Small Cell Lung Cancer.  ACS Omega,      [PMID:36873026] [10.1021/acsomega.2c07647]

2. Yuyao Jiang, Yanru Guan, Ruidong Chen, Jason T. Magnuson, Wen Zexin, Zijie Ding, Leyi Zhang, Wumuerzati Maermaer, Yuanyuan Liu, Shuying Li, Wenjun Gui, Daniel Schlenk.  (2025)  Chlorpyrifos cardiotoxic responses may be mediated by phagocytic activation in larval zebrafish.  Environmental Chemistry and Ecotoxicology,      [PMID:] [10.1016/j.enceco.2025.12.001]