Determine the necessary mass, volume, or concentration for preparing a solution.
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Why this grade
Moligand™, ≥99% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Descripción general
VRK-IN-1 is a potent and selective inhibitor of vaccinia-related kinases 1 (VRK1) , with an IC 50 of 150 nM. VRK1 is human Ser/Thr protein kinases associated with increased cell division and neurological disorders
In Vitro
VRK-IN-1 binds to VRK1-FL by enthalpy-driven, with a K d of 190 nM. VRK-IN-1 (0.4-25 μM; 24 h) slightly decreases the viability of human HeLa cells at the concentration of 3.2 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:IC50: 150 nM (VRK1)
Specifications
Especificaciones y pureza
Moligand™, ≥99%
Mecanismos bioquímicos y fisiológicos
VRK-IN-1 is a potent and selective inhibitor of vaccinia-related kinases 1 (VRK1) , with an IC 50 of 150 nM. VRK1 is human Ser/Thr protein kinases associated with increased cell division and neurological disorders.
Condiciones de almacenamiento de almacenamiento
Store at -20°C
Enviado en
Ice chest + Ice pads
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Grado
Moligand™
Pureza
≥99%
Nombres e identificadores
| Sonrisas canónicas | CC1=C(C=C(C=N1)C2=CC(=C(C(=C2)F)O)F)C3=CC(=C(C(=C3)F)O)F |
|---|---|
| IUPAC Name | 4-[5-(3,5-difluoro-4-hydroxyphenyl)-6-methylpyridin-3-yl]-2,6-difluorophenol |
| InChIKey | PMRGRXLXKYUDIH-UHFFFAOYSA-N |
| INCHI | 1S/C18H11F4NO2/c1-8-12(10-5-15(21)18(25)16(22)6-10)2-11(7-23-8)9-3-13(19)17(24)14(20)4-9/h2-7,24-25H,1H3 |
| Isómeros SMILES | CC1=C(C=C(C=N1)C2=CC(=C(C(=C2)F)O)F)C3=CC(=C(C(=C3)F)O)F |
| PubChem CID | 155511407 |
| Peso molecular | 349.28 |
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Estructura 3D
Modelo de Estructura Química Interactiva
Objetivos asociados (humanos)
HeLa (62764 Activities)
VRK1 Tbio Serine/threonine-protein kinase VRK1 (258 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Mecanismos de acción
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Fecha | Articulo |
|---|---|---|---|
 L2412739 | Certificate of Analysis | Dec 06, 2024 | V647791 |
| L2412740 | Certificate of Analysis | Dec 06, 2024 | V647791 |
| L2412741 | Certificate of Analysis | Dec 06, 2024 | V647791 |
| L2412742 | Certificate of Analysis | Dec 06, 2024 | V647791 |
| L2412743 | Certificate of Analysis | Dec 06, 2024 | V647791 |
| L2412744 | Certificate of Analysis | Dec 06, 2024 | V647791 |
| L2412745 | Certificate of Analysis | Dec 06, 2024 | V647791 |
| L2412746 | Certificate of Analysis | Dec 06, 2024 | V647791 |
| L2412747 | Certificate of Analysis | Dec 06, 2024 | V647791 |
| L2412748 | Certificate of Analysis | Dec 06, 2024 | V647791 |
| L2412749 | Certificate of Analysis | Dec 06, 2024 | V647791 |
Show more ⌵
Propiedades químicas y físicas
| Solubilidad | DMSO : 100 mg/mL (286.30 mM; Need ultrasonic) |
|---|
Calculadoras de soluciones
Reseñas
Reseñas de cliente
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View Moligand™ grade guide →Remind me later
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