VU 0364439 - 10mM in DMSO , CAS No.1246086-78-1

CAS: 1246086-78-1 Cat. No.: V408515 Fórmula: C₁₈H₁₃Cl₂N₃O₃S Peso molecular: 422.29 PubChem CID: 46934289

CALIDAD & PUREZA 10mM in DMSO

Synonyms

2-Pyridinecarboxamide, N-[3-chloro-4-[[(2-chlorophenyl)amino]sulfonyl]phenyl]-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

VU 0364439 is amGlu4positive allosteric modulator (PAM), withEC50of 19.8 nM.
In vitro

In vivo

VU 0364439 possess less than ideal PK properties preventing their use as in vivo tools. It shows better stability in HLM (63% remaining) than RLM (2% remaining).
Cell Data

cell lines：HeLa, HCT116, HT29, LOVO, DU145, and NHDF cells

Concentrations：

Incubation Time：

Powder Purity:≥99%

Especificaciones

Sinónimos

2-Pyridinecarboxamide, N-[3-chloro-4-[[(2-chlorophenyl)amino]sulfonyl]phenyl]-

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

VU 0364439 is a mGlu4 positive allosteric modulator (PAM), with EC50 of 19.8 nM.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Nombres e identificadores

Isómeros SMILES

C1=CC=C(C(=C1)NS(=O)(=O)C2=C(C=C(C=C2)NC(=O)C3=CC=CC=N3)Cl)Cl

PubChem CID

46934289

Peso molecular

422.29

Objetivos asociados (humanos)

GRM4 Tchem Metabotropic glutamate receptor 4 (4 Activities)

Discover Target: GRM4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro DMSO: 58 mg/mL (199.69 mM); Ethanol: 58 mg/mL (199.69 mM); Water: Insoluble