VU6019650 - ≥98% , CAS No.V659239

CAS: V659239 Cat. No.: V659239 Peso molecular: 411.51

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

VU6019650 is a potent and selective orthosteric antagonist of M5 mAChR ( IC 50 =36 nM), can be used for opioid use disorder (OUD) relief. VU6019650 can cross blood brain barrier, potentially modulates the mesolimbic dopaminergic reward circuitry. VU601965

Appearance:Solid

IC50& Target:mAChR5|36 nM (IC|50|)

In Vitro:VU6019650 (0-10 μM) shows high selectivity for M5 (IC 50 =36 nM) over other subtypes (>100-fold selectivity against human M 1-4 ). VU6019650 (1 μM) blocks Oxo-M-induced activation of VTA neurons. VU6019650 exhibits brain penetrance with rat brai

In Vivo:VU6019650 (10-56.6mg/kg; i.p.; single dose) inhibits the rewarding effects of Oxycodone and reduces oxycodone self-administration in rats. Pharmacokinetic Analysis in ratsRoute Dose mg/kg) t (term) (min) MRT (min) Cl_obs (mL/min/kg) Vd ss (L/k

Biological Activity:VU6019650 is a potent and selective orthosteric antagonist of M5 mAChR ( IC 50 =36 nM), can be used for opioid use disorder (OUD) relief. VU6019650 can cross blood brain barrier, potentially modulates the mesolimbic dopaminergic reward circuitry. VU601965

Specifications

Especificaciones y pureza

≥98%

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Pureza

≥98%

Nombres e identificadores

• Sonrisas canónicas: O=S(C1=CC2=C(OCC2)C=C1)(N(CC[C@@H]3CSC4=NC=CN4C)C[C@@H]3F)=O
• Peso molecular: 411.51