Vitamin K epoxide reductase inhibitor. Synthetic coumarin derivative. Shows anticoagulant effects in vivo. Orally active.
Condiciones de almacenamiento de almacenamiento
Argon charged, Room temperature
Enviado en
Normal
Tipo de acción
INHIBITOR
Mecanismo de acción
Vitamin k epoxide reductase complex subunit 1 isoform 1 inhibitor
Nota
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This compound belongs to the class of organic compounds known as coumarins and derivatives. These are polycyclic aromatic compounds containing a 1-benzopyran moiety with a ketone group at the C2 carbon atom (1-benzopyran-2-one).
External Descriptors
Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
1.Li Jiale, Li Haoyang, Pei Shizeng, Kang Na, Zhang Guomei, Zhang Caihong, Shuang Shaomin. (2022) Sensitive Detection of Sulfur Dioxide by Constructing a Protein Supramolecular Complex: a New Fluorescence Sensing Strategy. Food Analytical Methods, 16 (1):(55-62). [PMID:][10.1007/s12161-022-02365-5]
2.Yunchang Fan, Dongxu Cai, Xin Wang, Lei Yang. (2018) Ionic Liquids: Efficient Media for the Lipase-Catalyzed Michael Addition. MOLECULES, 23 (9):(2154). [PMID:30150588][10.3390/molecules23092154]
3.Dai Xiaochan, Yang Xi, Feng Yifan, Wu Xinyuan, Ju Yahan, Zou Rong, Yuan Fei. (2025) The role of vitamin K and its antagonist in the process of ferroptosis-damaged RPE-mediated CNV. Cell Death & Disease, 16 (1):(1-15). [PMID:40108164][10.1038/s41419-025-07497-0]
4.Lin Xi, Hu Shiyun, Li Yanxia, Yu Lishuang, Huang Lu. (2025) Enantioseparation by cLC-UV using chiral packed capillary columns with photonic crystal fibers as frits. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, [PMID:40715534][10.1007/s00216-025-06020-w]
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