WAY 200070 - Moligand™, ≥98% , Agonist of Estrogen receptor-α;Agonist of Estrogen receptor-β, CAS No.440122-66-7, Agonist of Estrogen receptor-α;Agonist of Estrogen receptor-β
GRADE & PURITYMoligand™?Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.≥98%
WAY-200070 is a potent, selective estrogen receptor-beta (ER-β) agonist (IC50 2.3 nM vs. 155 nM for ER-α) with anxiolytic-like and antidepressant-like effects.
Product Application：
WAY-200070, a selective estrogen receptor-beta (ER-β) agonist, may be used in estrogen receptor signaling research along with other ERβ agonists [diarylpropionitrile (DPN)] and antagonist to help identify and differentiate the functions of estrogen receptor-beta(s) (ER-β) involved in processes such as regulation of the physiology of the endocrine pancreas; modulation of visceral pain; and stress response. WAY-200070 may be used to help establish that an observed physiological or cell signaling response is ER-β-dependent, especially versus ERα.
Selective ERβreceptor agonist that displays 68-fold selectivity over ERα(EC50values are 2 and 155 nM for ERβand ERαrespectively). Displays antianxiolytic and antidepressive effectsin vivo.
Condiciones de almacenamiento de almacenamiento
Store at 2-8°C
Enviado en
Wet ice
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Grado
Moligand™
Tipo de acción
AGONIST
Mecanismo de acción
Agonist of Estrogen receptor-α;Agonist of Estrogen receptor-β
This compound belongs to the class of organic compounds known as phenyl-1,3-oxazoles. These are aromatic heterocyclic compounds containing a 1,3-oxazole substituted at one or more positions by a phenyl group.
External Descriptors
Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Solvent:DMSO, Max Conc. mg/mL: 30.61, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 15.31, Max Conc. mM: 50
Peso molecular
306.110 g/mol
XLogP3
3.400
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Rotatable Bond Count
1
Exact Mass
304.969 Da
Monoisotopic Mass
304.969 Da
Topological Polar Surface Area
66.500 Ų
Heavy Atom Count
18
Formal Charge
0
Complexity
296.000
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
The total count of all stereochemical bonds
0
Covalently-Bonded Unit Count
1
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C2320787