WZ3146 - 10mM in DMSO , CAS No.1214265-56-1

CAS: 1214265-56-1 Cat. No.: W409245 Fórmula: C₂₄H₂₅ClN₆O₂ Peso molecular: 464.96 PubChem CID: 44607360

GRADE & PURITY 10mM in DMSO

Synonyms

N-(3-(5-chloro-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

WZ3146 is a mutant-selective irreversible inhibitor ofEGFR(L858R)andEGFR(E746_A750)withIC50of 2 nM and 2 nM; does not inhibit ERBB2 phosphorylation (T798I).
In vitro

WZ3146 significantly suppresses the growth of EGFR mutation containing cell lines with IC50 of 3 nM in EGFR Del E746_A750 containing HCC827 cells, 15 nM in EGFR Del E746_A750 containing PC9 cells, 29 nM in EGFR L858R/T790M containing H1975 cells and 3 nM in EGFR Del E746_A750/T790M containing PC9 GR cells.

In vivo

Cell Data

cell lines：

Concentrations：0-10 μM

Incubation Time：72 hours

Powder Purity:≥99%

Specifications

Sinónimos

N-(3-(5-chloro-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

WZ3146 is a mutant-selective irreversible inhibitor of EGFR(L858R) and EGFR(E746_A750) with IC50 of 2 nM and 2 nM; does not inhibit ERBB2 phosphorylation (T798I).

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Nombres e identificadores

Isómeros SMILES

CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(=N3)OC4=CC=CC(=C4)NC(=O)C=C)Cl

PubChem CID

44607360

Peso molecular

464.96

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro DMSO: 10 mg/mL (39.01 mM)