XMD-12 - Moligand™,≥98% , Inhibitor of aurora kinase A;Inhibitor of aurora kinase B;Inhibitor of leucine rich repeat kinase 2, CAS No.1234481-08-3, Inhibitor of aurora kinase A;Inhibitor of aurora kinase B;Inhibitor of leucine rich repeat kinase 2

CAS: 1234481-08-3 Cat. No.: X614900 Fórmula: C₂₄H₂₆N₆O₂ Peso molecular: 430.50

CALIDAD & PUREZA Moligand™, ≥98%

Synonyms

Aurora kinase-IN-5

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Descripción general

XMD-12is an Aurora kinase (Aurora Kinase) inhibitor with anti-tumor activity that promotes paclitaxelinduced cell death. XMD-12 exhibits high selectivity and potency against Aurora A, B, and C kinases, with IC50 values of 5.6, 18.4, and 24.6 nM, respectively.

Especificaciones

Sinónimos

Aurora kinase-IN-5

Especificaciones y pureza

Moligand™,≥98%

Condiciones de almacenamiento de almacenamiento

Store at -20°C,Argon charged

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

INHIBITOR

Mecanismo de acción

Inhibitor of aurora kinase A;Inhibitor of aurora kinase B;Inhibitor of leucine rich repeat kinase 2

Pureza

≥98%

Nombres e identificadores

Pubchem Sid

528768502

Sonrisas canónicas

Cn1c2ccccc2c(=O)n(c2cnc(nc12)Nc1ccc(cc1)N1CCC(CC1)O)C

IUPAC Name

2-[4-(4-hydroxypiperidin-1-yl)anilino]-5,11-dimethylpyrimido[4,5-b][1,4]benzodiazepin-6-one

InChIKey

DFQAJLQXPSPNJE-UHFFFAOYSA-N

INCHI

1S/C24H26N6O2/c1-28-20-6-4-3-5-19(20)23(32)29(2)21-15-25-24(27-22(21)28)26-16-7-9-17(10-8-16)30-13-11-18(31)12-14-30/h3-10,15,18,31H,11-14H2,1-2H3,(H,25,26,27)

Peso molecular

430.50

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Piperidines
      • Subclass Phenylpiperidines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Piperidines
• Subclass: Phenylpiperidines
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenylpiperidines
• Alternative Parents: Alkyldiarylamines Pyrimidodiazepines 1,4-benzodiazepines Dialkylarylamines Aniline and substituted anilines 1,4-diazepines Aminopyrimidines and derivatives Imidolactams Vinylogous amides Tertiary carboxylic acid amides Heteroaromatic compounds Secondary alcohols Lactams Amino acids and derivatives Secondary amines Azacyclic compounds Hydrocarbon derivatives Organic oxides Organopnictogen compounds
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Alkyldiarylamine - Phenylpiperidine - Pyrimidodiazepine - 1,4-benzodiazepine - Benzodiazepine - Tertiary aliphatic/aromatic amine - Dialkylarylamine - Aniline or substituted anilines - Aminopyrimidine - Para-diazepine - Imidolactam - Benzenoid - Monocyclic benzene moiety - Pyrimidine - Tertiary carboxylic acid amide - Vinylogous amide - Heteroaromatic compound - Amino acid or derivatives - Carboxamide group - Lactam - Tertiary amine - Secondary alcohol - Carboxylic acid derivative - Azacycle - Secondary amine - Organooxygen compound - Organonitrogen compound - Amine - Alcohol - Organic oxide - Organopnictogen compound - Hydrocarbon derivative - Organic nitrogen compound - Organic oxygen compound - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as phenylpiperidines. These are compounds containing a phenylpiperidine skeleton, which consists of a piperidine bound to a phenyl group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

LRRK2 Tchem Leucine-rich repeat serine/threonine-protein kinase 2 (0 Activities)

Discover Target: LRRK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AURKA Tchem Aurora kinase A (0 Activities)

Discover Target: AURKA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AURKB Tchem Aurora kinase B (0 Activities)

Discover Target: AURKB

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPK7 Tchem Mitogen-activated protein kinase 7 (929 Activities)

Discover Target: MAPK7

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DCLK1 Tchem Serine/threonine-protein kinase DCLK1 (1025 Activities)

Discover Target: DCLK1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción