YLF-466D - 10mM in DMSO , CAS No.1273323-67-3

CAS: 1273323-67-3 Cat. No.: Y656140 Peso molecular: 465.93 PubChem CID: 51033997

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

YLF-466D is a newly developed AMPK activator, which inhibits platelet aggregation.

In Vitro

The effect of YLF-466D on platelet AMPK and aggregation are examined to test whether YLF-466D can stimulate AMPK in platelets and thereby suppress aggregation. Platelet AMPK is activated by YLF-466D, which is confirmed with activation-dependent phosphorylation at Thr172. Consistent with this result, YLF-466D inhibits platelet aggregation induced by thrombin. Such inhibition is observed in the aggregation elicited by ADP and collagen as well as thrombin, indicating that the antiaggregatory effect of YLF-466D is not platelet-agonist specific but common, regardless of agonist type. All the effects on AMPK and aggregation are concentration-dependent with the highest efficacy at 150 μM. IC 50 against thrombin-, ADP- and collagen-induced aggreation are approximately 84, 55 and 87 μM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:AMPK

Specifications

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

YLF-466D is a newly developed AMPK activator, which inhibits platelet aggregation.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Nombres e identificadores

• Isómeros SMILES: C1=CC=C(C=C1)/C(=C\2/C3=CC=CC=C3N(C2=O)CC4=CC(=CC=C4)C(=O)O)/C5=CC=C(C=C5)Cl
• PubChem CID: 51033997
• Peso molecular: 465.93