YS-370 - ≥98% , CAS No.2470908-79-1
Disponible
SKU
Y646618
YS-370 (compound 44) is a potent, high selective, and orally active inhibitor of P-glycoprotein ( P-gp ). YS-370 stimulates the P-gp ATPase activity and has moderate inhibition against CYP3A4. YS-370 effectively reverses multidrug resistance (MDR) to paclitaxel and colchicine in SW620/AD300 and HEK293T-ABCB1 cells. YS-370 in combination with paclitaxel achieves much stronger antitumor activity.
Form:Solid
Más Información
| CAS | 2470908-79-1 |
|---|---|
| Especificaciones y pureza | ≥98% |
| Condiciones de almacenamiento de almacenamiento | Store at -20°C |
| Enviado en | Ice chest + Ice pads |
| Product Description | YS-370 (compound 44) is a potent, high selective, and orally active inhibitor of P-glycoprotein ( P-gp ). YS-370 stimulates the P-gp ATPase activity and has moderate inhibition against CYP3A4. YS-370 effectively reverses multidrug resistance (MDR) to paclitaxel and colchicine in SW620/AD300 and HEK293T-ABCB1 cells. YS-370 in combination with paclitaxel achieves much stronger antitumor activity. Form:Solid |
| Solubilidad | DMSO : 8.33 mg/mL (12.55 mM; ultrasonic and warming and heat to 80°C) |
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