Z-Gln-Gly - ≥98% , CAS No.6610-42-0

CAS: 6610-42-0 Cat. No.: G121389 Peso molecular: 337.33 Número EC: 892-850-1

GRADE & PURITY ≥98%

Synonyms

ácido (S)-2-(5-amino-2-(((benciloxi)carbonil)amino)-5-oxopentanamido)acético | N2-[(fenilmetoxi)carbonil]-L-glutaminil-glicina

Storage

Conservar a -20°C

Shipped In

Hielera + almohadillas de hielo

Descripción general

sustrato donante de γ-glutamilo utilizado en la determinación espectrofotométrica de la actividad de la transglutaminasa (TGasa).Z-Gln-Gly se utilizó para sintetizar enzimáticamente neoglicoproteínas ligadas a N.

Specifications

Sinónimos

ácido (S)-2-(5-amino-2-(((benciloxi)carbonil)amino)-5-oxopentanamido)acético | N2-[(fenilmetoxi)carbonil]-L-glutaminil-glicina

Especificaciones y pureza

≥98%

Mecanismos bioquímicos y fisiológicos

La N-benciloxicarbonil-L-Glu-taminilglicina (Z-Gln-Gly, Z-QG) se utiliza como sustrato para diferenciar y caracterizar las transglutaminasas (TGase) que catalizan la reticulación covalente postraduccional de los péptidos que contienen Gln y Lys. Z-QG es c

Condiciones de almacenamiento de almacenamiento

Conservar a -20°C

Enviado en

Hielera + almohadillas de hielo

Pureza

≥98%

Nombres e identificadores

• Pubchem Sid: 504764461
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504764461
• Sonrisas canónicas: C1=CC=C(C=C1)COC(=O)NC(CCC(=O)N)C(=O)NCC(=O)O
• IUPAC Name: 2-[[(2S)-5-amino-5-oxo-2-(phenylmethoxycarbonylamino)pentanoyl]amino]acetic acid
• InChIKey: SOUXAAOTONMPRY-NSHDSACASA-N
• INCHI: 1S/C15H19N3O6/c16-12(19)7-6-11(14(22)17-8-13(20)21)18-15(23)24-9-10-4-2-1-3-5-10/h1-5,11H,6-9H2,(H2,16,19)(H,17,22)(H,18,23)(H,20,21)/t11-/m0/s1
• Isómeros SMILES: C1=CC=C(C=C1)COC(=O)N[C@@H](CCC(=O)N)C(=O)NCC(=O)O
• WGK Alemania: 3
• Peso molecular: 337.33
• Reaxy-Rn: 2546590
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2546590&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Clase Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Peptides
          • Level6 Dipeptides

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Clase: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Peptides
• Direct Parent: Dipeptides
• Alternative Parents: Glutamine and derivatives N-acyl-alpha amino acids Alpha amino acid amides Benzyloxycarbonyls N-acyl amines Carbamate esters Secondary carboxylic acid amides Primary carboxylic acid amides Monocarboxylic acids and derivatives Carboxylic acids Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Alpha-dipeptide - Glutamine or derivatives - N-acyl-alpha-amino acid - N-acyl-alpha amino acid or derivatives - Alpha-amino acid amide - N-substituted-alpha-amino acid - Alpha-amino acid or derivatives - Benzyloxycarbonyl - Monocyclic benzene moiety - Fatty amide - N-acyl-amine - Fatty acyl - Benzenoid - Carbamic acid ester - Carboxamide group - Primary carboxylic acid amide - Secondary carboxylic acid amide - Monocarboxylic acid or derivatives - Carboxylic acid - Organic nitrogen compound - Organic oxide - Organic oxygen compound - Carbonyl group - Hydrocarbon derivative - Organonitrogen compound - Organooxygen compound - Aromatic homomonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as dipeptides. These are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propiedades químicas y físicas

• Peso molecular: 337.330 g/mol
• XLogP3: -0.400
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 10
• Exact Mass: 337.127 Da
• Monoisotopic Mass: 337.127 Da
• Topological Polar Surface Area: 148.000 Ų
• Heavy Atom Count: 24
• Formal Charge: 0
• Complexity: 462.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referencias

1. Weijun Leng, Ying Li, Li Yuan, Xiuting Li, Ruichang Gao.  (2024)  Functional and Mechanistic Dissection of Protein Glutaminase PG3 and Its Rational Engineering for Enhanced Modification of Myofibrillar Proteins.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:39269985] [10.1021/acs.jafc.4c05590]

2. Si-Jie Wu, Ran Feng, Ran Meng, Qiu-Ya Ji, Han Tao, Bao Zhang.  (2025)  Nanogel cage based on oxidized sodium alginate sacrificial template: Enhanced stability and protein crosslinking performance of immobilized TGase.  CARBOHYDRATE POLYMERS,      [PMID:41116523] [10.1016/j.carbpol.2025.124368]

3. Zhang Ruxin, Chen Zhiwei, Wang Shuo, Li Bing, Chen Xiangyu, Lu Wenhui, Zhu Deyi, Gao Fengchun.  (2025)  Cation-π Driven Innovative Gelatin-based Hydrogels with ultrahigh adhesion and Self-healing capabilities.  GIANT,      [PMID:] [10.1016/j.giant.2025.100361]