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Zamicastat - Moligand™,≥98% , Dopamine beta-hydroxylase inhibitor, CAS No.1080028-80-3, Dopamine beta-hydroxylase inhibitor

CAS: 1080028-80-3 Cat. No.: Z412408 Peso molecular: 401.5 PubChem CID: 25052630
COA
Zamicastat - Moligand™,≥98% CAS No(1080028-80-3) Z412408 by Aladdin Scientific
Disponible para pedir
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
Synonyms
(R)-5-(2-(benzylamino)ethyl)-1-(6,8-difluorochroman-3-yl)-1H-imidazole-2(3H)-thione | BIA 5-1058 | EX-A3318 | 4-[2-(benzylamino)ethyl]-3-[(3R)-6,8-difluoro-3,4-dihydro-2H-chromen-3-yl]-1H-imidazole-2-thione | UNII-YLU32D0DNV | ZSSLCFLHEFXANG-GOSISDBHSA-N
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
★
 ·  off list, applied to all prices below.
Size
Estado
Price
Qty
5mg
Z412408-5mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
199,90US$
1mg
Z412408-1mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
83,90US$
25mg
Z412408-25mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
557,90US$
50mg
Z412408-50mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
869,90US$
Enter a quantity for the sizes you want to add.
Bulk / Custom
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SDS
Safety data
COA
Certificate
DS
Datasheet
SP
Spec sheet
Descripción general Specifications Propiedades del producto Nombres e identificadores Documentation Advanced Data Taxonomic Classification Estructura 3D Certificados (CoA, COO, BSE/TSE y tabla de análisis) Propiedades químicas y físicas Calculadoras de soluciones Reseñas
🧪

Why this grade

Moligand™,≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Descripción general

Information

Zamicastat (BIA 5-1058) is an inhibitor of dopamine β-hydroxylase (DBH) that could cross the blood-brain barrier (BBB) and cause central as well as peripheral effects. Zamicastat is also a concentration-dependent dual P-gp and BCRP inhibitor with IC50 of 73.8 μM and 17.0 μM, respectively. Zamicastat reduces high blood pressure.

Specifications

Sinónimos
(R)-5-(2-(benzylamino)ethyl)-1-(6, 8-difluorochroman-3-yl)-1H-imidazole-2(3H)-thione | BIA 5-1058 | EX-A3318 | 4-[2-(benzylamino)ethyl]-3-[(3R)-6, 8-difluoro-3, 4-dihydro-2H-chromen-3-yl]-1H-imidazole-2-thione | UNII-YLU32D0DNV | ZSSLCFLHEFXANG-GOSISDBHSA-N
Especificaciones y pureza
Moligand™, ≥98%
Mecanismos bioquímicos y fisiológicos
Zamicastat (BIA 5-1058) is an inhibitor of dopamine β-hydroxylase (DBH) that could cross the blood-brain barrier (BBB) and cause central as well as peripheral effects. Zamicastat is also a concentration-dependent dual\xa0P-gp\xa0and\xa0BCRP\xa0inhibitor w
Condiciones de almacenamiento de almacenamiento
Store at -20°C
Enviado en
Ice chest + Ice pads
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Grado
Moligand™
Tipo de acción
INHIBITOR
Mecanismo de acción
Dopamine beta-hydroxylase inhibitor
Pureza
≥98%
Propiedades del producto
ALogP3.2
Nombres e identificadores
Sonrisas canónicasC1C(COC2=C1C=C(C=C2F)F)N3C(=CNC3=S)CCNCC4=CC=CC=C4
IUPAC Name4-[2-(benzylamino)ethyl]-3-[(3R)-6,8-difluoro-3,4-dihydro-2H-chromen-3-yl]-1H-imidazole-2-thione
InChIKeyZSSLCFLHEFXANG-GOSISDBHSA-N
INCHI1S/C21H21F2N3OS/c22-16-8-15-9-18(13-27-20(15)19(23)10-16)26-17(12-25-21(26)28)6-7-24-11-14-4-2-1-3-5-14/h1-5,8,10,12,18,24H,6-7,9,11,13H2,(H,25,28)/t18-/m1/s1
Isómeros SMILES C1[C@H](COC2=C1C=C(C=C2F)F)N3C(=CNC3=S)CCNCC4=CC=CC=C4
PubChem CID 25052630
Peso molecular 401.5

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganoheterocyclic compounds
ClaseBenzopyrans
Subclass1-benzopyrans
Intermediate Tree Nodes Not available
Direct Parent1-benzopyrans
Alternative Parents Phenylmethylamines  Benzylamines  Aralkylamines  Alkyl aryl ethers  N-substituted imidazoles  Imidazolethiones  Aryl fluorides  Heteroaromatic compounds  Thioureas  Oxacyclic compounds  Dialkylamines  Azacyclic compounds  Organofluorides  Hydrocarbon derivatives  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents 1-benzopyran - Benzylamine - Phenylmethylamine - Alkyl aryl ether - Aralkylamine - Aryl fluoride - Aryl halide - Monocyclic benzene moiety - Imidazole-2-thione - N-substituted imidazole - Benzenoid - Azole - Heteroaromatic compound - Imidazole - Thiourea - Azacycle - Oxacycle - Secondary amine - Secondary aliphatic amine - Ether - Organooxygen compound - Organosulfur compound - Organic oxygen compound - Hydrocarbon derivative - Organonitrogen compound - Organic nitrogen compound - Amine - Organohalogen compound - Organofluoride - Aromatic heteropolycyclic compound
DescripciónThis compound belongs to the class of organic compounds known as 1-benzopyrans. These are organic aromatic compounds that 1-benzopyran, a bicyclic compound made up of a benzene ring fused to a pyran, so that the oxygen atom is at the 1-position.
External Descriptors Not available
Estructura 3D
Modelo de Estructura Química Interactiva





Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Propiedades químicas y físicas
Peso molecular401.500 g/mol
XLogP33.200
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass401.137 Da
Monoisotopic Mass401.137 Da
Topological Polar Surface Area68.600 Ų
Heavy Atom Count28
Formal Charge0
Complexity584.000
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Calculadoras de soluciones
Reseñas

Reseñas de cliente

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