ZM 306416 - Moligand™, 10mM in DMSO , Inhibitor of epidermal growth factor receptor;Inhibitor of fms related receptor tyrosine kinase 1;Inhibitor of kinase insert domain receptor, CAS No.690206-97-4, Inhibitor of epidermal growth factor receptor;Inhibitor of fms related receptor tyrosine kinase 1;Inhibitor of kinase insert domain receptor

CAS: 690206-97-4 Cat. No.: Z409010 Peso molecular: 333.74 PubChem CID: 5329006

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

CB 676475 | 4-Quinazolinamine, N-(4-chloro-2-fluorophenyl)-6,7-dimethoxy-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

ZM 306416 (CB 676475) is a VEGFR (Flt and KDR) inhibitor forVEGFR1withIC50of 0.33 μM, but also found to inhibit EGFR with IC50 of <10 nM.
In vitro

ZM-306416 induces selective antiproliferative effect toward the EGFR-addicted NSCLC cell lines H3255 and HCC4011 with IC50 of 0.09 µM and 0.072 µM, respectively. ZM-306416 inhibits granule formation with IC50 of 0.67 μM. ZM-306416 significantly inhibits the ERRα assay with IC50 of 7.3 μM in the GeneBLAzer T-Rex RORγ-UAS-bla HEK293T cell line. ZM306416 (300 nM) completely inhibits PAA secretion and stimulates [¹²⁵]I uptake in human thyroid follicular cells. ZM306416 (300 nM) abolishes pVEGFR2 (Y1214) expression in human thyroid follicular cells. ZM306416 (< 10 μM) has marked inhibitory effects on the steady state phosphorylation of p42/44 MAPK but does not affect the expression of the unphosphorylated form. ZM306416 (3 μM) significantly increases cell death in human thyroid follicular cells. ZM306416 (3 μM) significantly increases cell death in human thyroid follicular cells. ZM306416 weakly inhibits the secretion of VEGF and increases the production of PlGF. ZM306416 (1 μM) enhances follicle formation and decreased nuclear distribution in human thyroid follicular cells.

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

CB 676475 | 4-Quinazolinamine, N-(4-chloro-2-fluorophenyl)-6, 7-dimethoxy-

Especificaciones y pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos y fisiológicos

ZM 306416 (CB 676475) is a VEGFR (Flt and KDR) inhibitor for VEGFR1 with IC50 of 0.33 μM, but also found to inhibit EGFR with IC50 of <10 nM.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

INHIBITOR

Mecanismo de acción

Inhibitor of epidermal growth factor receptor;Inhibitor of fms related receptor tyrosine kinase 1;Inhibitor of kinase insert domain receptor

Nombres e identificadores

• Isómeros SMILES: COC1=C(C=C2C(=C1)C(=NC=N2)NC3=C(C=C(C=C3)Cl)F)OC
• PubChem CID: 5329006
• Peso molecular: 333.74

Objetivos asociados (humanos)

EGFR Tclin Epidermal growth factor receptor (1 Activities)

Discover Target: EGFR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KDR Tclin Vascular endothelial growth factor receptor 2 (1 Activities)

Discover Target: KDR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro DMSO: 4 mg/mL (14.69 mM); Water: Insoluble; Ethanol: Insoluble