Zoledronic acid monohydrate(CGP 42446; ZOL 446) is an activator of protein kinase C with apoptotic effects on multiple myeloma cell lines. It inhibited proliferation of human foetal osteoblastic cell line (hFOB) with an IC50 of 40 uM.
A highly potent bisphosphonate and activator of PKC.

Specifications

Sinónimos

Especificaciones y pureza

≥98%(HPLC)

Mecanismos bioquímicos y fisiológicos

Zoledronic acid monohydrate, also known as cgp 42'446, is a heterocyclic bisphosphonate that is considered to have the highest potency of bisphosphonates for suppression of increased bone resorption and has been used in several osteoporosis studies. The c

Condiciones de almacenamiento de almacenamiento

Store at 2-8°C, Protected from light

Enviado en

Wet ice

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Pureza

≥98%(HPLC)

Nombres e identificadores

Pubchem Sid	504756844
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504756844
Sonrisas canónicas	C1=CN(C=N1)CC(O)(P(=O)(O)O)P(=O)(O)O.O
IUPAC Name	(1-hydroxy-2-imidazol-1-yl-1-phosphonoethyl)phosphonic acid;hydrate
InChIKey	FUXFIVRTGHOMSO-UHFFFAOYSA-N
INCHI	1S/C5H10N2O7P2.H2O/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7;/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14);1H2
Isómeros SMILES	C1=CN(C=N1)CC(O)(P(=O)(O)O)P(=O)(O)O.O
WGK Alemania	3
CAS alternativo	165800-06-6
Términos de entrada MeSH	2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosphonic acid;CGP 42'446;CGP 42446;CGP 42446A;CGP-42'446;CGP-42446;CGP42'446;CGP42446;zoledronate;zoledronic acid;zoledronic acid anhydrous;Zometa
Peso molecular	290.11

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

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✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

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📊 Datasheet

Quick-reference summary of product specifications and applications.

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🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

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Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organic acids and derivatives
  - Clase Organic phosphonic acids and derivatives
    - Subclass Bisphosphonates

Kingdom	Organic compounds
Superclass	Organic acids and derivatives
Clase	Organic phosphonic acids and derivatives
Subclass	Bisphosphonates
Intermediate Tree Nodes	Not available
Direct Parent	Bisphosphonates
Alternative Parents	N-substituted imidazoles Organic phosphonic acids Heteroaromatic compounds Azacyclic compounds Organopnictogen compounds Organophosphorus compounds Organooxygen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	Bisphosphonate - N-substituted imidazole - Azole - Imidazole - Organophosphonic acid - Heteroaromatic compound - Azacycle - Organoheterocyclic compound - Organic nitrogen compound - Organophosphorus compound - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Aromatic heteromonocyclic compound
Descripción	This compound belongs to the class of organic compounds known as bisphosphonates. These are organic compounds containing two phosphonate groups linked together through a carbon atoms.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Estructura 3D

Objetivos asociados (humanos)

CA2 Tclin Carbonic anhydrase II (17698 Activities)

Discover Target: CA2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

FDPS Tclin Farnesyl diphosphate synthase (1240 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GGPS1 Tchem Geranylgeranyl pyrophosphate synthetase (715 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CA1 Tclin Carbonic anhydrase I (13240 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CA14 Tclin Carbonic anhydrase XIV (1305 Activities)

Discover Target: CA14

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MMP8 Tchem Matrix metalloproteinase 8 (1942 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MMP14 Tchem Matrix metalloproteinase 14 (1592 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CA12 Tclin Carbonic anhydrase XII (6231 Activities)

Discover Target: CA12

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CA9 Tclin Carbonic anhydrase IX (8255 Activities)

Discover Target: CA9

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Homo sapiens (32628 Activities)

Lot Number	Certificate Type	Fecha	Articulo
H2507800	Certificate of Analysis	Jul 07, 2025	Z140117
H2507803	Certificate of Analysis	Jul 07, 2025	Z140117
E23301266	Certificate of Analysis	Mar 04, 2025	Z140117
E23301277	Certificate of Analysis	Mar 04, 2025	Z140117
F2308473	Certificate of Analysis	Jun 16, 2023	Z140117
F2308468	Certificate of Analysis	Jun 16, 2023	Z140117
F2308474	Certificate of Analysis	Jun 16, 2023	Z140117
E23301301	Certificate of Analysis	May 22, 2023	Z140117

Solubilidad	Soluble in water (7 mg/ml), 0.1N NaOH, methanol (0.12 mg/ml at 25 °C), and ethanol (0.13 mg/ml at 25 °C).
Sensibilidad	Moisture & Light & Heat sensitive
Peso molecular	290.110 g/mol
XLogP3
Hydrogen Bond Donor Count	6
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	4
Exact Mass	290.007 Da
Monoisotopic Mass	290.007 Da
Topological Polar Surface Area	154.000 Å²
Heavy Atom Count	17
Formal Charge	0
Complexity	327.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

Zoledronic Acid Monohydrate - ≥98%(HPLC) , CAS No.165800-06-6

Why this grade

Storage & shipping

Quality documents

Literature proof

Descripción general

Specifications

Documentation

📋 Safety Data Sheet (SDS)

✅ Certificate of Analysis (COA)

📊 Datasheet

🔬 Specification Sheet

Advanced Data

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