2-PMPA - ≥98%(HPLC) , CAS No.173039-10-6

CAS: 173039-10-6 Cat. No.: P167889 분자식: C₆H₁₁O₇P 분자량: 226.12 EC 번호: 998-881-8 PubChem CID: 10130754

GRADE & PURITY ≥98%(HPLC)

Synonyms

HMS3412K10 | HMS3676K10 | HY-100788 | 2-PMPA, >=98% (HPLC) | PMPA(NAALADaseinhibitor) | Pentanedioic acid, 2-(phosphonomethyl)- | UNII-XH88WJG9LJ | AKOS016004257 | HMS3749M13 | HMS3267D10 | (R,S)-2-phosphonomethylpentanedioic acid | YGA03910 | SCHEMBL3831

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Specifications

동의어

HMS3412K10 | HMS3676K10 | HY-100788 | 2-PMPA, >=98% (HPLC) | PMPA(NAALADaseinhibitor) | Pentanedioic acid, 2-(phosphonomethyl)- | UNII-XH88WJG9LJ | AKOS016004257 | HMS3749M13 | HMS3267D10 | (R,S)-2-phosphonomethylpentanedioic acid | YGA03910 | SCHEMBL3831

사양 및 순도

≥98%(HPLC)

생화학 및 생리적 메커니즘

2-PMPA 是一种有效的（IC50 ~ 1 nM）选择性谷氨酸羧肽酶 II（GCPII）抑制剂，也称为 N-乙酰基-L-天冬氨酰-L-谷氨酸肽酶 I（NAALADase I）、NAAG 肽酶或前列腺素-特异性膜抗原（PSMA）。2-PMPA 具有神经保护活性。2-PMPA 在多发性硬化症的 EAE 模型中已被证明可预防和治疗认知障碍，并防止梭曼诱导的神经病理学。 2-PMPA 是谷氨酸羧肽酶 II（GCPII）的有效选择性抑制剂。 2-（膦酰基甲基）戊二酸（2-PMPA）阻断由低单位剂量的可卡因维持的静

보관 조건

Store at -20°C,Argon charged

배송

Ice chest + Ice pads

이 제품은 콜드 체인 배송이 필요합니다.지상 및 기타 경제 서비스는 사용할 수 없습니다.

작업 유형

INHIBITOR

순수함

≥98%(HPLC)

이름과 식별자

• Pubchem Sid: 504765270
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504765270
• 정식 스마일: C(CC(=O)O)C(CP(=O)(O)O)C(=O)O
• IUPAC Name: 2-(phosphonomethyl)pentanedioic acid
• InChIKey: ISEYJGQFXSTPMQ-UHFFFAOYSA-N
• INCHI: 1S/C6H11O7P/c7-5(8)2-1-4(6(9)10)3-14(11,12)13/h4H,1-3H2,(H,7,8)(H,9,10)(H2,11,12,13)
• 이성체 SMILES: C(CC(=O)O)C(CP(=O)(O)O)C(=O)O
• RTECS: SA0454800
• PubChem CID: 10130754
• 분자량: 226.12

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • 분류 Carboxylic acids and derivatives
      • Subclass Dicarboxylic acids and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• 분류: Carboxylic acids and derivatives
• Subclass: Dicarboxylic acids and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Dicarboxylic acids and derivatives
• Alternative Parents: Fatty acids and conjugates Organic phosphonic acids Carboxylic acids Organophosphorus compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Fatty acid - Dicarboxylic acid or derivatives - Organophosphonic acid derivative - Organophosphonic acid - Carboxylic acid - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organophosphorus compound - Organooxygen compound - Carbonyl group - Aliphatic acyclic compound
• 설명: This compound belongs to the class of organic compounds known as dicarboxylic acids and derivatives. These are organic compounds containing exactly two carboxylic acid groups.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

관련 대상(인간)

FOLH1 Tclin Glutamate carboxypeptidase 2 (15 Activities)

Discover Target: FOLH1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NAALAD2 Tchem N-acetylated-alpha-linked acidic dipeptidase 2 (1 Activities)

Discover Target: NAALAD2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FOLH1 Tclin Glutamate carboxypeptidase II (711 Activities)

Discover Target: FOLH1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NAALAD2 Tchem NAALADase II (20 Activities)

Discover Target: NAALAD2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

관련 대상(비인간)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mus musculus (284745 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasma (328 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

작용 메커니즘

화학 및 물리적 특성

• 용해성: Soluble to 100 mM in sterile water
• 감도: Moisture sensitive
• 분자량: 226.120 g/mol
• XLogP3: -2.200
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 6
• Exact Mass: 226.024 Da
• Monoisotopic Mass: 226.024 Da
• Topological Polar Surface Area: 132.000 Ų
• Heavy Atom Count: 14
• Formal Charge: 0
• Complexity: 267.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1