20-COOH-LTB4 - ≥97%, 100 μg/ml in ethanol , CAS No.80434-82-8

CAS: 80434-82-8 Cat. No.: C353436 분자식: C₂₀H₃₀O₆ 분자량: 366.45 EC 번호: 632-880-2 PubChem CID: 5280877

GRADE & PURITY ≥97%, 100 μg/ml in ethanol

Synonyms

BML1-E06 | HY-113483 | (S-(R*,S*-(E,Z,E,Z)))-5,12-dihydroxy-6,8,10,14-Eicosatetraenedioate | 20-carboxyleukotriene B4 | 20-Carboxy-leukotriene B4 | 20-Carboxy-leukotriene- B4 | (S-(R*,S*-(E,Z,E,Z)))-5,12-dihydroxy-6,8,10,14-Eicosatetraenedioic acid | C059

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

개요

20-COOH-LTB|4|is an ω-oxidized metabolite of leukotriene B|4|. Leukotrienes have been shown to be potent eicosanoid lipid mediators derived from phospholipase-released Arachidonic Acid . These compounds have been reported to be involved in inflammation and numerous homeostatic biological functions. In rat hepatocytes, 20-COOH-LTB|4|is noted to be a substrate for β-oxidation pathways found in peroxisomes and mitochondria.

Specifications

동의어

BML1-E06 | HY-113483 | (S-(R*,S*-(E,Z,E,Z)))-5,12-dihydroxy-6,8,10,14-Eicosatetraenedioate | 20-carboxyleukotriene B4 | 20-Carboxy-leukotriene B4 | 20-Carboxy-leukotriene- B4 | (S-(R*,S*-(E,Z,E,Z)))-5,12-dihydroxy-6,8,10,14-Eicosatetraenedioic acid | C059

사양 및 순도

≥97%, 100 μg/ml in ethanol

보관 조건

Store at -20°C

배송

Ice chest + Ice pads

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작업 유형

INHIBITOR

순수함

≥97%

제품 특성

• pKa: pKa: 4.66

이름과 식별자

• 정식 스마일: C(CCC(=O)O)CC=CCC(C=CC=CC=CC(CCCC(=O)O)O)O
• IUPAC Name: (5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxyicosa-6,8,10,14-tetraenedioic acid
• InChIKey: SXWGPVJGNOLNHT-VFLUTPEKSA-N
• INCHI: 1S/C20H30O6/c21-17(11-6-2-1-3-9-15-19(23)24)12-7-4-5-8-13-18(22)14-10-16-20(25)26/h2,4-8,12-13,17-18,21-22H,1,3,9-11,14-16H2,(H,23,24)(H,25,26)/b5-4+,6-2-,12-7+,13-8-/t17-,18-/m1/s1
• 이성체 SMILES: C(CCC(=O)O)C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O
• WGK 독일: 3
• PubChem CID: 5280877
• 분자량: 366.45

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lipids and lipid-like molecules
    • 분류 Fatty Acyls
      • Subclass Fatty acids and conjugates

• Kingdom: Organic compounds
• Superclass: Lipids and lipid-like molecules
• 분류: Fatty Acyls
• Subclass: Fatty acids and conjugates
• Intermediate Tree Nodes: Not available
• Direct Parent: Long-chain fatty acids
• Alternative Parents: Hydroxy fatty acids Unsaturated fatty acids Dicarboxylic acids and derivatives Secondary alcohols Carboxylic acids Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Long-chain fatty acid - Hydroxy fatty acid - Unsaturated fatty acid - Dicarboxylic acid or derivatives - Secondary alcohol - Carboxylic acid - Carboxylic acid derivative - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Carbonyl group - Alcohol - Aliphatic acyclic compound
• 설명: This compound belongs to the class of organic compounds known as long-chain fatty acids. These are fatty acids with an aliphatic tail that contains between 13 and 21 carbon atoms.
• External Descriptors: Leukotrienes

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

작용 메커니즘

화학 및 물리적 특성

• 용해성: Soluble in water, ethanol, DMF, DMSO, and PBS pH 7.2.
• 굴절률: n20D1.55
• 발화점(°F): 57.2 °F
• 발화점(°C): 14 °C
• 끓는점(°C): 78° C
• 분자량: 366.400 g/mol
• XLogP3: 2.400
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 15
• Exact Mass: 366.204 Da
• Monoisotopic Mass: 366.204 Da
• Topological Polar Surface Area: 115.000 Ų
• Heavy Atom Count: 26
• Formal Charge: 0
• Complexity: 504.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 2
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 4
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 4
• Covalently-Bonded Unit Count: 1

자주 묻는 질문

What is the purity of this product?

This product is supplied at ≥97% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 80434-82-8, the molecular formula is C20H30O6, and the molecular weight is 366.45 g/mol. InChIKey SXWGPVJGNOLNHT-VFLUTPEKSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.