8(S)-HETE - Moligand™,≥98%,100μg/ml in ethanol , Agonist of Peroxisome proliferator-activated receptor-α, CAS No.98462-03-4, Agonist of Peroxisome proliferator-activated receptor-α

CAS: 98462-03-4 Cat. No.: H342781 분자식: C₂₀H₃₂O₃ 분자량: 320.47 EC 번호: 633-689-7

GRADE & PURITY Moligand™, ≥98%, 100μg/ml in ethanol

Synonyms

NLUNAYAEIJYXRB-VYOQERLCSA-N | 8(S)-HETE | 8(S)-hydroxy-5(Z),9(E),11(Z),14(Z)-eicosatetraenoic acid | 8(S-hydroxy-(5Z, 9E, 11Z, 14Z)-eicosatetraenoic acid | 8(S)-Hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoic acid, ~100 mug/mL in ethanol, ~98% (HPLC) | GTPL2679

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

개요

8(S)-HETE is a major lipoxygenase product in PMA-treated murine epidermis. It activates mouse keratinocyte protein kinase C with an IC50 of 100 µM. 8(S)-HETE also activates PPARα selectively at concentrations as low as 0.3 µM. Stereochemical assignment of the (S) enantiomer is based on comparison of chiral HPLC retention times to published results.

Specifications

동의어

NLUNAYAEIJYXRB-VYOQERLCSA-N | 8(S)-HETE | 8(S)-hydroxy-5(Z),9(E),11(Z),14(Z)-eicosatetraenoic acid | 8(S-hydroxy-(5Z, 9E, 11Z, 14Z)-eicosatetraenoic acid | 8(S)-Hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoic acid, ~100 mug/mL in ethanol, ~98% (HPLC) | GTPL2679

사양 및 순도

Moligand™,≥98%,100μg/ml in ethanol

보관 조건

Store at -20°C

배송

Ice chest + Ice pads

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등급

Moligand™

작업 유형

AGONIST

작동 메커니즘

Agonist of Peroxisome proliferator-activated receptor-α

순수함

≥98%

이름과 식별자

정식 스마일

CCCCCC=CCC=CC=CC(CC=CCCCC(=O)O)O

IUPAC Name

(5Z,8S,9E,11Z,14Z)-8-hydroxyicosa-5,9,11,14-tetraenoic acid

InChIKey

NLUNAYAEIJYXRB-VYOQERLCSA-N

INCHI

1S/C20H32O3/c1-2-3-4-5-6-7-8-9-10-13-16-19(21)17-14-11-12-15-18-20(22)23/h6-7,9-11,13-14,16,19,21H,2-5,8,12,15,17-18H2,1H3,(H,22,23)/b7-6-,10-9-,14-11-,16-13+/t19-/m1/s1

이성체 SMILES

CCCCC/C=C\C/C=C\C=C\[C@H](C/C=C\CCCC(=O)O)O

WGK 독일

3

분자량

320.47

Reaxy-Rn

29201509

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=29201509&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lipids and lipid-like molecules
    • 분류 Fatty Acyls
      • Subclass Eicosanoids

• Kingdom: Organic compounds
• Superclass: Lipids and lipid-like molecules
• 분류: Fatty Acyls
• Subclass: Eicosanoids
• Intermediate Tree Nodes: Not available
• Direct Parent: Hydroxyeicosatetraenoic acids
• Alternative Parents: Long-chain fatty acids Hydroxy fatty acids Unsaturated fatty acids Secondary alcohols Monocarboxylic acids and derivatives Carboxylic acids Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Hydroxyeicosatetraenoic acid - Long-chain fatty acid - Hydroxy fatty acid - Fatty acid - Unsaturated fatty acid - Secondary alcohol - Carboxylic acid derivative - Carboxylic acid - Monocarboxylic acid or derivatives - Organic oxide - Organic oxygen compound - Alcohol - Hydrocarbon derivative - Carbonyl group - Organooxygen compound - Aliphatic acyclic compound
• 설명: This compound belongs to the class of organic compounds known as hydroxyeicosatetraenoic acids. These are eicosanoic acids with an attached hydroxyl group and four CC double bonds.
• External Descriptors: Hydroxy/hydroperoxyeicosatetraenoic acids

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

관련 대상(인간)

PPARA Tclin Peroxisome proliferator-activated receptor alpha (1 Activities)

Discover Target: PPARA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

화학 및 물리적 특성

• 용해성: Soluble in ethanol, and DMSO. Insoluble in water.
• 발화점(°F): 57.2 °F
• 발화점(°C): 14 °C
• 끓는점(°C): 78° C
• 분자량: 320.500 g/mol
• XLogP3: 5.200
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 14
• Exact Mass: 320.235 Da
• Monoisotopic Mass: 320.235 Da
• Topological Polar Surface Area: 57.500 Ų
• Heavy Atom Count: 23
• Formal Charge: 0
• Complexity: 392.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 4
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 4
• Covalently-Bonded Unit Count: 1

자주 묻는 질문

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 98462-03-4, the molecular formula is C20H32O3, and the molecular weight is 320.47 g/mol. InChIKey NLUNAYAEIJYXRB-VYOQERLCSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.